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Biomedical subjects

E O'Brien

Publications and source records attributed to E O'Brien.

At least 91 records · Page 5Linked to original sources

Compliance in elderly hypertensives.

Hypertension is common in the elderly. While it is possible to reduce blood pressure in this age group, the value of such treatment in terms of reduced mortality and morbidity is unknown. The effects of a prescribed regimen depends inter alia on compliance. Therefore, this variable must be taken into account in assessing drug treatment in the elderly hypertensive. In general, the elderly comply well with drug treatment but there are a number of well defined problems in this age group.

Adult

The role of home and ambulatory blood pressure recording in the management of hypertension.

A review of the literature shows that doctor-recorded measurement (DRM) of blood pressure is higher than patient-recorded measurement (PRM) by either home-recording or ambulatory measurement. The role of home-recording and ambulatory measurement as a means of supplementing doctor-recorded measurement is discussed. The results of two studies comparing home-recording with clinic and ambulatory blood pressure showed that home-recording of blood pressure did not lower blood pressure.

Blood Pressure Determination

Attitude change and a prison health care experience.

Nursing in a prison setting has recently emerged as a field of concern. One of the issues in staff working with prisoners is attitudes and attitude change. Since the most favorable site for attitude formation and/or change is a student's educational experience, the present study was undertaken to explore if nursing students who have a clinical experience with prisoners will demonstrate a change toward more favorable attitudes toward prisoners. The research design was a pre-test, post-test control group design. The instrument was a Likert scale, adapted from previously developed scales dealing with attitudes toward prisoners, the mentally ill, and drug addicts. An important control was contained in the instrument, in that not only were there statements dealing with prisoners, but also dealing with the mentally ill and addicts, with whom none of the students would have student clinical experience. The results revealed that there was no significant difference in attitudes toward prisoners, drug addicts, and the mentally ill on the pre-test for either experimental or control group. However, on the post-test, there was a significantly lower (more positive) score on the scale for prisoners for the experimental group, who had a prison clinical experience. This finding suggests that attitudes can be favorably altered by a relevant student clinical experience.

Attitude

Antihypertensive and renal haemodynamic effects of atenolol and nadolol in elderly hypertensive patients.

As little is known of the antihypertensive efficacy or renal haemodynamic effects of beta-adrenoceptor blocking drugs in the elderly we studied two such drugs, atenolol and nadolol, in elderly hypertensive patients. Ten patients took part in a placebo-controlled double-blind study of atenolol and 10 received nadolol in a single-blind placebo-controlled study. Treatment phases lasted 12 weeks for atenolol or 10 weeks for nadolol. Blood pressure, effective renal blood flow and glomerular filtration rate data obtained at the end of each treatment phase were analysed. Atenolol lowered mean arterial pressure (mean +/- s.e. mean) from 129.9 +/- 1.5 to 108.2 +/- 2.3 mm Hg (P less than 0.01) while it increased mean effective renal blood flow 512.5 +/- 86.6 to 646.0 +/- 116.1 ml min-1 1.73 m-2 (P less than 0.05). Nadolol reduced mean arterial pressure from 133.2 +/- 2.0 to 113.5 +/- 3 mm Hg (P less than 0.001) but reduced mean effective renal blood flow from 558.8 +/- 32.2 to 446.0 +/- 26.9 ml min-1 1.73 m-2 (P less than 0.05). Glomerular filtration did not alter significantly with either drug. We conclude that beta-adrenoceptor blocking drugs are effective antihypertensive agents in the elderly but have disparate effects on effective renal blood flow perhaps because of differences in cardioselectivity. These data suggest that comparative studies with thiazide diuretics and beta-adrenoceptor blocking drugs are warranted in elderly hypertensives.

Adrenergic beta-Antagonists