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Biomedical subjects

E Obreshkova

Publications and source records attributed to E Obreshkova.

8 recordsLinked to original sources
PubMed1999

Scleroderma profunda. Clinicopathological studies.

Scleroderma profunda represents an unusual clinical entity. There are no unified criteria for its diagnosis. Seven patients with scleroderma profunda were studied. The clinical features can be summarised in three groups: 1. hyperpigmented plaques with subcutaneous induration; 2. erythematous plaques with induration of the skin and subcutis; 3. pale indurated plaques with atrophy and sometimes ulcerobullous lesions. Histology showed sclerodermiform changes in the deep dermis and subcutis and vasculitis in one case. Dermal lymphocytic infiltration was well pronounced in 5 cases and consisted of predominantly CD3+ T cells. Differential diagnosis from panniculitis can be difficult. Mucin deposition was established in all cases.

Adolescent↗
PubMed1998

Keratosis lichenoides chronica.

Keratosis lichenoides chronica is a rare dermatosis characterized by a distinctive seborrheic dermatitis-like facial eruption, together with violaceous, papular, and nodular lesions on the extremities and trunk typically arranged in a linear and reticulate pattern. We describe a patient with KLC who had the typical features of this disease and responded partially to treatment with oral isotretinoin.

Adult↗
PubMed1979

[Argyria in the prolonged use of adsorgan].

One case of agryria is reported that developed after a long-term administration of adsorgan in a patient with dyspeptic manifestations after cholecystectomy. The developed skin syndrome -- ashen-grey discolorization of the skin of the face and bare parts of the hands and the neurological symptoms -- right monoparesis and vestibular-disturbances with clinical manifestations of chronic cholangiohepatitis, pancreatitis and gastroduodentitis -- provided considerable diagnostic difficulties. The problem of argyria is discussed as a state of intoxication in chronic use of silver-containing medicaments. The necessity of differentiating argyria by the internists is stressed upon in order to avoid it as a complication in the administration of drugs-containing silver, adsorgan resp., being applied in the physician's practice.

Adult↗
PubMedDate not supplied

Candida granuloma and sarcoidosis.

Chronic mucocutaneous candidosis has been described in patients with impaired cell-mediated immunity. We describe a female patient with sarcoidosis who developed a Candida granuloma on her upper lip. Moderate impairment of the cell-mediated immunity was detected. Three months' treatment with ketoconazole was successful, but the lesion recurred at the same place after treatment was stopped.

Candidiasis, Cutaneous↗