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Biomedical subjects

E Ohtake

Publications and source records attributed to E Ohtake.

At least 19 recordsLinked to original sources
PubMed1999

[Uptake of 201TlCl and 99mTc-tetrofosmin in neurofibroma: a case report].

A 34-year-old man with neurofibromatosis type 1 (von Recklinghausen's disease) was examined by 201TlCl and 99mTc-tetrofosmin scintigraphies. Hypervascularity was observed in the largest tumor of the right thigh. The tumor was also depicted on both scintigrams. Tumorectomy was performed and the pathologic examination revealed it to be a neurofibroma measuring 10 x 7 x 4 cm in size. These findings suggested that 201TlCl and 99mTc-tetrofosmin scintigraphies generally were unable to distinguish malignant from benign neurofibromas with certainty.

Adult↗
PubMed1993

[ATP radionuclide ventriculography; its usefulness for the evaluation of ischemic heart disease].

To evaluate the usefulness for the detection of ischemic heart disease (IHD), ATP first pass radionuclide ventriculography (RVG) was performed in 10 patients. Coronary angiography was performed in all patients. Among these patients, 2 had single vessel disease, 2 had double vessel disease, 3 had triple vessel disease, and 3 had normal coronary arteries. RVG was performed at rest, then, ATP was infused at the rate of 0.16 mg/kg/min and ATP-RVG was done 4 minutes later. The left ventricular ejection fraction (LVEF) was calculated, and the regional wall motion (RWM) was graded as normal, hypokinesis, akinesis, and dyskinesis. In the patients with coronary artery disease, RWM decreased in 5 of 7 patients and LVEF decreased in 6 of 7 patients by ATP. However, RWM and LVEF did not decrease in the patients with normal coronary arteries. These results suggested that ATP-RVG might provide useful information for the evaluation of IHD.

Adenosine Triphosphate↗
PubMed1992

[Discrepancy between 123I-IMP SPECT and X-ray CT in chronic cerebrovascular disease].

The discrepancy between the low accumulation area (LAA) seen on 123I-IMP SPECT and the low density area (LDA) on X-ray CT was evaluated in 76 cases with chronic cerebrovascular disease. In 19 patients, LAA was larger than LDA beyond the vascular territory. Brain angiogram showed either obstruction or stenosis of the major arteries in as many as 59 percentages of this discrepancy group. In many patients of this group, cortical neurological symptoms were observed. In 37 patients in which the size of LAA was equal to that of LDA, abnormality of the major arteries was observed in only 7 percentages. These results indicated that the discrepancy mainly reflected the infarction due to irreversible ischemic change of perforate artery with the cortical low perfusion caused by the major artery disease. In some patients, the discrepancy was believed to show the remote effect caused by neurological pathway disturbance.

Adult↗
PubMed1992

[Evaluation of I-123-BMIPP myocardial SPECT on the detection of ischemic heart disease by comparing with stress thallium-201 myocardial SPECT].

To evaluate the usefulness of I-123-BMIPP as a tracer of fatty acid metabolism in ischemic heart disease, we performed both rest BMIPP myocardial SPECT and stress thallium-201 (Tl) SPECT in 15 patients with prior myocardial infarction, and compared the segmental findings each other. The abnormality of BMIPP images was more intense than that of Tl redistribution images (Tl-RD) in more than 60% of the abnormal segments. The degree of myocardial uptake of BMIPP was more concordant with that of Tl stress scan (Tl-EX) than with that of Tl-RD. This agreement of the findings between BMIPP and Tl-EX was found more remarkably in the regions of incomplete Tl redistribution or in the collateralized regions. These results revealed that ischemia in the jeopardized regions was able to be detected even by rest BMIPP scan. Abnormal findings in BMIPP were observed in more than 95% of segments with persistent defects or incomplete redistribution in Tl, but observed in only 41 or 45% of segments with complete redistribution. Normal findings in BMIPP were observed in 94% of normal segments in Tl. From these results, we can speculate that abnormal regions in BMIPP may have necrotic or ischemic myocardial tissue and normal regions in BMIPP may not have necrotic tissue. These results suggest that I-123-BMIPP may be available to detect myocardial ischemia or infarction in the clinical study. Additionally, the difference in findings between the early images and the delayed images in rest BMIPP scan was observed with relatively high incidence (14% of regions and 73% of patients). More detailed analysis will be required to reveal the importance of this difference.

Aged↗
PubMed1991

[A study on crosstalk correction in dual energy acquisition of 123I-MIBG and 201TlCl in myocardial SPECT].

In the simultaneous dual energy acquisition, energy spectrums of two radionuclides crosstalk each other and this phenomenon is a cause of the poor quality of images. In order to obtain the image of high quality in dual energy acquisition of 123I-MIBG and 201TlCl, a crosstalk correction method was originated. The crosstalk from 201Tl to 123I window (R1) and the crosstalk from 123I to 201Tl window (R2) were determined by the cardiac phantom studies. R1 and R2 showed almost constant value throughout the myocardial wall. The crosstalk correction was performed using R1 and R2. After the crosstalk correction, the defect region placed in the cardiac phantom was detected more clearly both in visual interpretation and in quantitative analysis. The crosstalk correction method with R1 and R2 was applied to some clinical cases. By the crosstalk correction, the quality of image was improved and a false defect caused by crosstalk disappeared in a clinical case. The crosstalk correction was considered to be useful for improving the quality of image on dual energy acquisition.

3-Iodobenzylguanidine↗
PubMed1991

[Usefulness of thallium-201 myocardial SPECT using dipyridamole infusion combined with low level exercise for the detection of the ischemic heart disease--comparison with SPECT images by maximum physical exercise in the same patients].

To evaluate the usefulness of thallium-201 myocardial SPECT using dipyridamole infusion combined with low level exercise (Dp-method) for the detection of the ischemic heart disease, we performed both Dp-method and maximum physical exercise SPECT (Ex-method) in the same 28 patients, and compared the results obtained by the two methods. In the visual evaluation, the detectability of each stenotic coronary territory by Dp-method tended to be higher than that by Ex-method (accuracy 71% vs 67%). The severity of the defect and the degree of the redistribution were higher by Dp-method than those by Ex-method. In the washout rate (WR) analysis in 14 angina pectoris patients, the detectability (accuracy) by Dp-method was significantly higher than that by Ex-method (86% vs 64%; p less than 0.05). In comparison of mean WR values in normal subjects (10 cases for Dp-method and other 8 cases for Ex-method), mean WR by Dp-method was as high as that by Ex-method and the deviation of WR value among subjects was very small. This was probably due to the effect of the low level exercise. These results suggested that Dp-method was more excellent than Ex-method in the evaluation of the ischemic heart disease, and was a useful method of the daily routine work. The incidence of chest symptom and the electrocardiographic ST-depression was as high by Dp-method as that by Ex-method. The filling defects in Dp-method were thought to be induced not only by the difference in the relative increase of the myocardial perfusion, but also by the myocardial ischemia.

Adult↗
PubMed1989

[Reverse redistribution in the stress thallium scan--correlation of coronary blood flow and myocardial damage].

In order to make clear 'reverse redistribution (RR)' phenomenon in stress thallium scan we investigated 477 consecutive patients who were consisted of 74 cases with PTCA (PTCA group), 86 cases with coronary artery bypass graft (CABG group) and 317 cases without any revascularization (N group). RR was detected in 12 cases out of PTCA group (16%), in 11 cases out of CABG group (13%) and in 10 cases out of N group (3.2%), and the incidence of RR in PTCA or CABG group was higher than that of N group (p less than 0.01). In 33 patients with RR the cases without significant coronary artery stenosis were more than those with stenosis (p less than 0.01) and the cases with myocardial damage were more than those without damage (p less than 0.01). In quantitative analysis washout rate at the RR areas showed relatively high value, but it was not significant compared with normal value (53 +/- 9.0% vs. 49 +/- 1.9%). In conclusion, RR had a tendency to appear in the condition of normal myocardium mingled with scar and of sufficient coronary blood flow. The mechanism of the phenomenon was thought to be that initial uptake of thallium in the partially scarred area was as high as in the normal myocardium, but washout of thallium from its remaining normal myocardium is normal or faster so that the defect appears at the myocardium mingled with scar. Therefore existence of reverse redistribution suspects the myocardium mingled with scar and sufficient coronary blood flow to the remaining normal myocardium.

Adult↗
PubMed1989

[Clinical usefulness of physiologic components obtained by factor analysis--application to 99mTc-DTPA renography].

The clinical usefulness of physiological components obtained by factor analysis was assessed in 99mTc-DTPA renography. Using definite physiological components, another dynamic data could be analyzed. In this paper, the dynamic renal function after ESWL (Extracorporeal Shock Wave Lithotripsy) treatment was examined using physiological components in the kidney before ESWL and/or a normal kidney. We could easily evaluate the change of renal functions by this method. The usefulness of a new analysis using physiological components was summarized as follows: 1) The change of a dynamic function could be assessed in quantity as that of the contribution ratio. 2) The change of a sick condition could be morphologically evaluated as that of the functional image.

Adult↗
PubMed1986

Lymphoscintigraphy in patients with lymphedema. A new approach using intradermal injections of technetium-99m human serum albumin.

Forty cases were examined by a new lymphoscintigraphic approach using intradermal injections of Tc-99m human serum albumin (HSA). Thirty-three patients had lymphedema due to the metastases of a malignant tumor and/or the dissection of lymph nodes. The others were control patients without lymphedema. With the assistance of a computer, sequential images and time-activity curves of tracer activity in the lymph nodes and the soft tissue were obtained at 30 minutes after injection. An image of the axillary or inguinal lymph nodes was identified 2-6 minutes after injection in control cases. Four main abnormal findings, the delayed appearance of radioactivity and interruption of the lymphatic system, the collateral pathways, and the retrograde lymphatic flow were observed clearly, as was the nonvisualization of the lymph nodes. These abnormalities were observed in a high percentage of patients with moderate lymphedema, as compared with a low percentage of patients with slight lymphedema. The collateral pathways could not be observed in patients with severe lymphedema. Imaging with Tc-99m HSA was considered to be more useful than other techniques, including radiocolloid lymphoscintigraphy, for examining patients with lymphedema.

Adult↗