[Prostacyclin in ischemic stroke].
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Biomedical subjects
Publications and source records attributed to E Olczyk.
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In a group of 1621 patients with vascular brain lesions (849 males, 772 females) the authors found seizures in 108 cases (56 males, 52 females): in 26 cases of subarachnoid haemorrhage (aneurysms), 6 cerebral haemorrhages, 24 cerebral arterial thromboses, 18 atherosclerosis of brain vessels, 13 cases of embolia, 4 cases of transient cerebral ischaemia, 4 cases of vertebrobasilar insufficiency, 4 cases of cerebrocardiac syndromes, 2 cases of cerebral form of the Winiwarter-Buerger disease and 1 cases each of cerebellar haemorrhage and aortic arch syndrome. In 8 cases family history of epilepsy was elicited. The authors suggest administration of anticonvulsants in justified cases.
The authors studied 286 patients with epilepsy with disease onset past the age of 20 years (176 males, 110 females) from the urban and rural populations. In 57% of cases the aetiology of epilepsy was undetermined. Among the known aetiological factors head trauma accounted for 15.5% of cases, inflammatory processes in the central nervous system for 4.5%, alcoholism for 7%, vascular lesions for 6%, tumours for 5.2%, degenerative and atrophic changes for 1.5%. Over 40% of patients had had attacks for up to 15 years and over 18% for over 20 years. In 80% of cases grand mal seizures occurred, and in 33% of these cases more than 12 attacks occurred annually. Six cases of status epilepticus were observed with 2 deaths. The attacks were precipitated by menstruation, alcohol abuse, infection, stressed, television watching. Among the signs accompanying or following the seizures tongue biting and urination prevailed. Neurological signs were demonstrated in 21% of cases, encephalopathy in 65%, other psychic disturbances in 9.5%. Systematic treatment was received by 75% of the patients (over 80% in urban population), and therapy with multiple drugs was most frequent. Drug-resistant epilepsy was found in 34% of cases. The patients from the rural population had a lower educational level and had more children. About 70% of the patients were in employment.(ABSTRACT TRUNCATED AT 250 WORDS)
The authors defined the morbidity index of late epilepsy (MI) on the ground of notified cases in the population aged over 20 years (with first seizure past the age of 20 years) comprising 228273 individuals (125453 living in towns and 102820 living in villages) in the years 1979-1980. The index was calculated per 1000 of the population. The general index was 2.23 (males--2.77; females--1.72). The value of the index was highest in the age group 20-29 years (3.75) and 40-49 years (2.58) in males, and in females this value was also at its peaks in these age groups (2.63 and 1.93, respectively). In the whole population the index had also two peaks in these age groups: 3.21 and 2.55 respectively. In the urban population the general index was 2.33 (2.77 in males and 1,91 in females) being again highest in the age groups 20-29 and 40-49 years. Similar peaks were found in these age groups in the urban male and female populations. In the rural population the general index was 2.11 (males 2.77, females 1.49) and the peaks were in the age groups 20-29 and 30-39 years. In males these peaks were in the age groups 20-29 and 40-49, and in females in the groups 20-29 and 30-39 years. The lowest index value was in the age group over 60 years in the whole population (1.22), in the urban population (1.62 and in the rural population (0.91). In further studies on epilepsy the method of active search for epilepsy cases with full clinical and epidemiological analysis is being used.