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Biomedical subjects

E Orsitto

Publications and source records attributed to E Orsitto.

At least 19 recordsLinked to original sources

Hodgkin's lymphoma: an isolated case of involvement of the ureter.

We report the case of a man in which a Hodgkin's lymphoma involved the ureter as the very first clinical situs of the disease. Ureteral involvement in lymphomas is very rare (0.86%-7% and 1%-16%, found in two studies, respectively, of cases of patients with lymphoma examined post mortem) and when it does occur it is secondary to renal involvement or retroperitoneal adenopathies. It is by all means exceptional as an isolated situs of disease. Those cases reported in the literature as presenting lymphomatous involvement of the ureter have always been diagnosed as Non-Hodgkin's lymphomas.

Combined Modality Therapy↗

[Urotheliomas of the upper urinary tract. The role of computed tomography in integrated diagnostic imaging].

INTRODUCTION: Transitional cell carcinomas are frequent in the bladder but rare in the renal pelvis. Most upper urinary tract cancers are suspected and detected with urography and retrograde pyelography; CT is important in the questionable cases at US, urography and retrograde pyelography, but it is also useful to detect locoregional disease. We report the findings of 35 patients, with ureteral lesions to assess the role of CT in the diagnosis and staging. MATERIALS AND METHODS: Thirty-five patients were examined with US and CT; 27 underwent urography, 16 retrograde pyelography and 4 nephrostomic pyelography, CT staging was made with Hahn's criteria related to TNM (stages CT I, CT II, CT III). All patients underwent surgery and the histologic findings were compared with CT staging. RESULTS: CT detected all lesions and characterized them from a morphological viewpoint (intraluminal minus, wall thickening). Using Hahn's CT staging we obtained agreement with histologic findings in 21 of 23 cases in CT stage I, six of 10 in CT stage II and 4 of 5 in CT stage III. CONCLUSIONS: CT is an important tool for both diagnosis and therapy because it shows the renal cavities and parenchyma and permits accurate staging, differentiating the tumors localized in the wall from those with local spread or distant metastases. In our experience, CT is not useful to differentiate mucosal from pelvic-ureteral muscle invasion but peripelvic and periureteral fat invasion can be suspected when the infiltrated wall exhibits an irregular and spiculated profile.

Adult↗

Sarcoidosis: single bulky mesenteric lymph node mimicking a lymphoma.

A previously healthy man presented with acute abdominal pain that extended from the left lumbar area to the left iliac fossa and to the omolateral testicular region. Abdominal ultrasonography and CT scan showed a bulky mesenteric mass and mesenteric, paraaortic, and paracaval lymph nodes. Biopsy specimens of the mass revealed non caseating granulomas. Chest CT scan and 67Gallium thoracic scan demonstrated lymph node and parenchymal pulmonary involvement. Bronchoalveolar lavage (BAL) confirmed the presence of a low intensity alveolitis. Serum angiotensin converting enzyme (SACE) level was elevated. Two years after steroid therapy, markers of disease activity and abdominal ultrasonography are in the normal range.

Adult↗

Cisapride improves gallbladder kinetics in patients affected with myotonic muscular dystrophy.

Smooth muscle involvement is relatively common in myotonic muscular dystrophy (MMD). The effects of cisapride on gallbladder motor function in myotonic patients have been investigated in 10 alithiasic patients and in 10 healthy volunteers. Gallbladder volumes were measured by ultrasonography in fasting state and 15, 30, 45 and 60 min after milk intake. The patients were treated with cisapride for two months, after which they underwent a second ultrasonographic examination. Gallbladder emptying was slower and less effective in dystrophic patients than in healthy volunteers. Cisapride was found to improve gallbladder kinetics (efficacy of contraction and rate of emptying) in patients affected with myotonic muscular dystrophy.

Adult↗

[The echographic diagnosis of acute appendicitis and its complications].

The authors report their experience with emergency US in patients hospitalized for clinical suspicion of acute appendicitis or presenting with pain in the right lower abdominal quadrant. One hundred fifty-two patients were examined with US: 93/152 had pathologies of the right iliac region; 81 of them underwent surgery (50/81 appendectomies). In 27 of these patients the inflamed appendix presented with a typical US pattern. All of them had surgical confirmation. In 13/50 cases, US findings followed an atypical pattern (6 patients had a periappendiceal mass in the right iliac region, 3 had small amounts of fluid in the Douglas pouch, and 4 had gas-filled bowel loops of the ileum). The false negatives were 10/50. US sensitivity was 80%, and its specificity was 54%. The most common pathologic conditions are described whose symptoms mimic those of acute appendicitis. US role in inflamed acute appendicitis is still to be defined. Nonetheless, the authors suggest that US be performed on all patients with atypical pain in the lower abdominal quadrants, because of its high diagnostic accuracy in many common pathologies mimicking appendicitis, especially urinary and uterine adnexal pathologies.

Acute Disease↗

[Loco-regional transcatheter thrombolysis].

Eight cases of recent arterial thrombosis (average time of symptoms: 11 days) are considered: 2 popliteal and 6 prosthetic thromboses (2 aorto-bifemoral and 4 femoropopliteal by-passes). After percutaneous catheterization, with catheter tip either in contact with or inside the thrombus, urokinase was locally injected (200,000 UI bolus, and 75,000 UI with slow infusion for 24 +/- 72 hours); general heparin treatment was also administered. PTA was employed in 2 cases (1 surgical anastomosis and 1 popliteal thrombosis). Arterial recanalization was always obtained within 72 hours in 2 aorto-bifemoral and in 1/4 femoropopliteal by-passes. Patency was also obtained in the 2 popliteal thrombosis.

Catheterization, Peripheral↗

[Echographic study of the popliteal region].

The paper reports an echographic study of the popliteal region designed to assess the utility of ultrasonography in the differential diagnosis of the various popliteal pathologies. In a year, 459 soft tissue samples were examined; 250 concerned the knee 138 patients gave negative results, while 112 cases presented this pathology with the following diagnosis: 94 cysts (21 appeared duplicated and monolateral, 28 duplicated and counterlateral), 2 aneurysms, 3 hematomas, 10 solid tumefactions (9 were benign, 1 malignant), 1 venous thrombosis and 2 chondromatosis. Of these 112 cases, 25 had been operated on, and the surgical reports quoted 15 cysts, 9 benign and 1 malignant neoplasm. The results of the study, when compared with the existing literature, highlight the essential role of ultrasound in the diagnostic approach to the pathology of the popliteal region.

Humans↗

[Galactographic features of the secreting breast].

The authors report their experience in the galactographic study of 95 women with nipple discharge; 65 of them previously underwent both surgical and histological control. The galactographic features are classified according to predominant alterations: ductal ectasia, ductal stenosis, ductal amputation, solitary/multiple filling defects, ductal dystrophy, and irregular distribution of ductal branches. Histopathological findings (65 patients) appear to be related to nipple discharge types: thus, hematic secretion results pathognomonic for intracanalicular neoplasm (24/25), while serous and serous-hematic discharge (32/65) may be caused by any mammary pathologies. Galactography is therefore recommended, being sometimes the only reliable diagnostic method and allowing both topography and extension of the lesion to be demonstrated, which are necessary elements for planning adequate surgical treatment.

Adult↗