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E Osetowska

Publications and source records attributed to E Osetowska.

14 recordsLinked to original sources
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[Experimental studies on a hereditary central nervous system disease in PT rabbits. V. Clinical syndrome in generations 1-10].

Sex-linked mutation designated by the genetic symbol pt causes in rabbits a syndrome of parkinsonian tremor and spastic paralysis of extremities. Clinical phenotypes were observed in 10 geenratoins. Fig. 1 shows the types of matings. The appearance in pt rabbits of clinical improvement permitting to use them for reproduction and abortive or asymptomatic cases appearing in later generations are connected by the authors with the fact the a healthy rabbit had been introduced into the flock (rabbit No 84432). This rabbit had the genetic trait M modifying the clinical course of the pt syndrome. In Mm heterozygotes clinical improvement was observed, in MM homozygotes abortive and asymptomatic courses occurred. The M trait must be transferred by autosomes. The hypothetical M trait explains the clinical phenomena observed in the pt group but it requires still confirmation by specially planned experimental matings.

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