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Biomedical subjects

E Ott

Publications and source records attributed to E Ott.

At least 19 recordsLinked to original sources
PubMed2005

Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass.

OBJECTIVES: We sought to evaluate the efficacy of recombinant human antithrombin III for restoration of heparin responsiveness in heparin-resistant patients scheduled for cardiac surgery. METHODS: This was a multicenter, randomized, double-blind, placebo-controlled study in heparin-resistant patients undergoing elective cardiac surgery. Patients were considered heparin resistant if the activated clotting time was less than 480 seconds after 400 U/kg heparin. Fifty-two heparin-resistant patients were randomized into 2 cohorts. One cohort received a single bolus (75 U/kg) of recombinant human antithrombin III (n = 28), and the other, the placebo group (n = 24), received a normal saline bolus. If the activated clotting time remained less than 480 seconds, this was defined as treatment failure, and 2 units of fresh frozen plasma were transfused. Patients were monitored for adverse events during hospitalization. RESULTS: Six (21%) of the patients in the recombinant human antithrombin III group received fresh frozen plasma transfusions compared with 22 (92%) of the placebo-treated patients ( P < .001). Two units of fresh frozen plasma did not restore heparin responsiveness. There was no increased incidence of adverse events associated with recombinant human antithrombin III administration. Postoperative 24-hour chest tube bleeding was not different in the 2 groups. Surrogate measures of hemostatic activation suggested that there was less activation of the hemostatic system during cardiopulmonary bypass in the recombinant human antithrombin III group. CONCLUSION: Treatment with recombinant human antithrombin III in a dose of 75 U/kg is effective in restoring heparin responsiveness and promoting therapeutic anticoagulation for cardiopulmonary bypass in the majority of heparin-resistant patients. Two units of fresh frozen plasma were insufficient to restore heparin responsiveness. There was no apparent increase in bleeding associated with recombinant human antithrombin III.

Adult↗
PubMed2005

Ictal dystonic posturing in mesial versus neocortical temporal lobe seizures.

PURPOSE: Ictal contralateral dystonic posturing is a frequently observed clinical feature in temporal lobe seizures. It is generally interpreted as the result of spread of the ictal discharge into basal ganglia structure. In previous reports, analysing ictal behavior, a precise definition and description of the upper limb ictal dystonia is often lacking or contradictory. In our study we aimed to determine whether different subtypes of dystonia and their latency from the clinical onset of seizure might be of value for the differentiation between mesial temporal lobe epilepsy (MTLE) and neocortical temporal lobe epilepsy (NTLE). METHODS: Eighty seizures (51 MTLE and 29 NTLE) and 30 patients (20 MTLE and 10 NTLE) were analyzed with regard to dystonic posturing of the upper limb. Ictal dystonia was subdivided into different subtypes according to distinct clinical features. Their frequency and latency from the clinical onset of seizure were assessed. RESULTS: Frequencies of all subtypes were similar in MTLE and NTLE. Concerning the latencies contralateral dystonic posturing characterized by sustained muscle contractions with flexion of the wrist and fist closure, a frequently appearing feature, occurred significantly earlier in NTLE than in MTLE seizures. CONCLUSIONS: This difference between the two groups may provide a differentiation between an epileptic focus of mesial from neocortical temporal lobe origin.

Adult↗
PubMed2003

Influence of age, gender, education and dexterity on upper limb motor performance in Parkinsonian patients and healthy controls.

Finger tapping, the most widely used test for evaluating motor dysfunction in Parkinson's disease (PD), was found to react sensitively to disease specific factors like disease severity and changes in medication. A possible interference caused by disease unrelated demographic factors--age, gender, education and dexterity--however has not yet been studied systematically. Various components of tapping performance of 187 healthy subjects and 200 PD patients were assessed by means of the BRAIN TEST, a digitalized test battery. The effects of demographic factors--above all education and age--were found to be significant. These influences generally affect different aspects of movement to a different extent, with speed and akinesia being affected more severely than dysmetria and arrhythmokinesis. Our study suggests that whenever precise assement of upper limb motor performance is needed, specific corrections for these demographic factors in both healthy controls and PD patients are necessary.

Adult↗
PubMed2002

Future aspects of the presurgical evaluation in epilepsy.

Epilepsy surgery is a successful therapeutic approach in patients with medically intractable epilepsy. The presurgical evaluation aims to detect the epileptogenic brain area by use of different diagnostic techniques. In this review article the current diagnostic procedures applied for this purpose are described. The diagnostic armamentarium can be divided conceptually into three different groups: assessment of function/dysfunction, structural/morphologic imaging methods and functional neuroimaging techniques. Properties, diagnostic power and limits of all diagnostic tools used in the diagnostic evaluation are discussed. In addition, future perspectives and the diagnostic value of new technologies are mentioned. Some are increasingly gaining acceptance in the routine preoperative diagnostic procedure like MR volumetry or MR spectroscopy of the hippocampus in patients with temporal lobe epilepsy. Some, on the other hand, like MEG and 11C-flumazenil PET, still remain experimental diagnostic tools as they are technically demanding and cost intensive. Besides the refinement of established techniques, co-registration of different modalities like spike-triggered functional MRI will play an important role in the non-invasive detection of the epileptic seizure focus and may change the regimen of the preoperative diagnostic work up of epilepsy patients in the future.

Brain Diseases↗
PubMed2001

Fractal properties of robust strange nonchaotic attractors.

For a simple class of quasiperiodically forced dynamical systems, we present a rigorous result supporting the idea that the attractors for this class of systems, although nonchaotic, are strange in the sense that their box-counting dimension is two while their information dimension is one. Furthermore, this result is stable to changes of the system, suggesting that the basic features leading to it may be present in typical quasiperiodically forced systems.

Journal Article↗
PubMed2001

Detecting phase synchronization in a chaotic laser array.

Detection of phase synchronization of coupled chaotic oscillators is examined experimentally for the case of a linear laser array. Phase variables are computed by applying a Gaussian filter, peaked at a positive frequency, to the signal obtained from the intensity time series of the individual lasers. Relationships between different frequency components of the oscillator dynamics that are not otherwise apparent are unambiguously detected.

Journal Article↗
PubMed2001

Local low dimensionality of atmospheric dynamics.

A statistic, the BV (bred vector) dimension, is introduced to measure the effective local finite-time dimensionality of a spatiotemporally chaotic system. It is shown that the Earth's atmosphere often has low BV dimension, and the implications for improving weather forecasting are discussed.

Journal Article↗
PubMed2001

Front propagation of spatiotemporal chaos.

We study the dynamics of the front separating a spatiotemporally chaotic region from a stable steady region using a simple model applicable to periodically forced systems. In particular, we investigate both the coarsening of the front induced by the inherent "noise" of the chaotic region, and the long wavelength dynamics causing the front to develop cusps.

Journal Article↗
PubMed2001

Blowout bifurcations and the onset of magnetic activity in turbulent dynamos.

The transition to magnetic-field self-generation in a turbulent, electrically conducting fluid is shown to exhibit intermittent bursting characterized by distinct scaling laws. This behavior is predicted on the basis of prior analysis of a type of bifurcation (called a blowout bifurcation) occurring in chaotic systems with an invariant phase space submanifold. The predicted scalings are shown to be consistent with numerical solutions of the governing magnetohydrodynamic equations, and implications for recently implemented experimental programs are discussed.

Journal Article↗
PubMed2001

Pattern selection in extended periodically forced systems: a continuum coupled map approach.

We propose that a useful approach to the modeling of periodically forced extended systems is through continuum coupled map (CCM) models. CCM models are discrete time, continuous space models, mapping a continuous spatially varying field xi(n)(x) from time n to time n+1. The efficacy of CCM models is illustrated by an application to experiments of Umbanhowar, Melo, and Swinney [Nature 382, 793 (1996)] on vertically vibrated granular layers. Using a simple CCM model incorporating temporal period doubling and spatial patterning at a preferred length scale, we obtain results that bear remarkable similarities to the experimental observations. The fact that the model does not make use of physics specific to granular layers suggests that similar phenomena may be observed in other (nongranular) periodically forced, strongly dissipative systems. We also present a framework for the analysis of pattern selection in CCM models using a truncated modal expansion. Through the analysis, we predict scaling laws of various quantities, and these laws may be verifiable experimentally.

Journal Article↗
PubMed2000

Testing whether two chaotic one dimensional processes are dynamically identical

Consider the situation where two individuals observe the same chaotic physical process but through time series of different measured variables (e.g., one individual measures a temperature and the other measures a voltage). If the two individuals now use their data to reconstruct (e.g., via delay coordinates) a map, the maps they obtain may appear quite different. In the case where the resulting maps appear one dimensional, we introduce a method to test consistency with the hypothesis that they represent the same physical process. We illustrate this method using experimental data from an electric circuit.

Journal Article↗
PubMed2000

Measurement of wave chaotic eigenfunctions in the time-reversal symmetry-breaking crossover regime

We present experimental results on eigenfunctions of a wave chaotic system in the continuous crossover regime between time-reversal symmetric and time-reversal symmetry-broken states. The statistical properties of the eigenfunctions of a two-dimensional microwave resonator are analyzed as a function of an experimentally determined time-reversal symmetry-breaking parameter. We test four theories of one-point eigenfunction statistics and introduce a new theory relating the one-point and two-point statistical properties in the crossover regime. We also find a universal correlation between the one-point and two-point statistical parameters for the crossover eigenfunctions.

Journal Article↗
PubMed2000

Lagrangian chaos and the effect of drag on the enstrophy cascade in two-dimensional turbulence

We investigate the effect of drag force on the enstrophy cascade of two-dimensional Navier-Stokes turbulence. We find a power law decrease of the energy wave number (k) spectrum that is faster than the classical (no-drag) prediction of k(-3). It is shown that the enstrophy cascade with drag can be analyzed by making use of a previous theory for finite lifetime passive scalars advected by a Lagrangian chaotic fluid flow. Using this we relate the power law exponent of the energy wave number spectrum to the distribution of finite time Lyapunov exponents and the drag coefficient.

Journal Article↗
PubMed2000

The Bradykinesia Akinesia Incoordination Test (BRAIN TEST), an objective and user-friendly means to evaluate patients with parkinsonism.

The BRAIN TEST, a computerized alternating finger tapping test, was performed on 154 patients with parkinsonism to assess whether the test could be used as an objective tool to evaluate reliably the severity of Parkinson's disease (PD). Patients were instructed to tap two marked computer keyboard keys as fast and as accurately as possible for 60 seconds. The test generates the following variables: (1) kinesia score (KS)--number of keystrokes/min, (2) akinesia time (AT)--cumulative time that keys are depressed, (3) dysmetria score (DS)--a weighted score generated from incorrectly hit keys and corrected for speed, and (4) arrhythmia score (AS)--variance of the time interval between individual keystrokes. Among parkinsonian patients, we found a significant correlation between the four test parameters and PD rating scores of the Hoehn & Yahr, Schwab & England, and Unified PD Rating Scales (KS, AS, and AT p <0.001 and DS p <0.05). When compared with 73 parkinsonian patients 73 age- and sex-matched control subjects showed significantly higher KS and lower AT (p <0.001) as well as lower DS and AS (p = 0.05). The BRAIN TEST is a reliable and practical tool for evaluating the severity of parkinsonism and for distinguishing subjects with parkinsonism from normal control subjects. A version of the BRAIN TEST is available by FTP on the worldwide web (http://www.anaesthetist.com/software/brain.htm).

Adult↗
PubMed2000

Spiral wave dynamics in oscillatory inhomogeneous media.

The effect of a long length scale static inhomogeneity on spiral wave dynamics is studied in the two-dimensional complex Ginzburg-Landau equation. We find that the inhomogeneity leads to the formation of a dominant spiral domain that suppresses other spiral domains, and that the spiral vortices slowly drift in the presence of an inhomogeneity with a velocity that is proportional to the local parameter gradients. We derive an expression for the spiral vortex drift velocity and present examples of both fixed point and limit cycle attractors of the spiral vortices.

Kinetics↗
PubMed2000

Optimal periodic orbits of continuous time chaotic systems

In previous work [B. R. Hunt and E. Ott, Phys. Rev. Lett. 76, 2254 (1996); Phys. Rev. E 54, 328, (1996)], based on numerical experiments and analysis, it was conjectured that the optimal orbit selected from all possible orbits on a chaotic attractor is "typically" a periodic orbit of low period. By an optimal orbit we mean the orbit that yields the largest value of a time average of a given smooth "performance" function of the system state. Thus optimality is defined with respect to the given performance function. (The study of optimal orbits is of interest in at least three contexts: controlling chaos, embedding of low-dimensional attractors of high-dimensional dynamical systems in low-dimensional measurement spaces, and bubbling bifurcations of synchronized chaotic systems.) Here we extend this previous work. In particular, the previous work was for discrete time dynamical systems, and here we shall consider continuous time systems (flows). An essential difference for flows is that chaotic attractors can have embedded within them, not only unstable periodic orbits, but also unstable steady states, and we find that optimality can often occur on steady states. We also shed further light on the sense in which optimality is "typically" achieved at low period. In particular, we find that, as a system parameter is tuned to be closer to a crisis of the chaotic attractor, optimality may occur at higher period.

Journal Article↗
PubMed2000

Target waves in the complex ginzburg-landau equation

We introduce a spatially localized inhomogeneity into the two-dimensional complex Ginzburg-Landau equation. We observe that this can produce two types of target wave patterns: stationary and breathing. In both cases, far from the target center, the field variables correspond to an outward propagating periodic traveling wave. In the breathing case, however, the region in the vicinity of the target center experiences a periodic temporal modulation at a frequency, in addition to that of the wave frequency of the faraway outward waves. Thus at a fixed point near the target, the breathing case yields a quasiperiodic time variation of the field. We investigate the transition between stationary and breathing targets, and note the existence of hysteresis. We also discuss the competition between the two types of target waves and spiral waves.

Journal Article↗