Biomedical subjects

E Ozer

Publications and source records attributed to E Ozer.

81 records · Page 5Linked to original sources

PubMedDate not supplied

Curschmann's spirals in cyst fluid associated with a teratoma of the ovary. A case report.

BACKGROUND: Curschmann's spirals, first described more than 100 years ago, are common in cytologic specimens from the respiratory tract and have also been observed in cervical smears, urine, and peritoneal and pleural effusions. No simple theory can explain the exact mode of spiral formation, which is presumed to be a complex physical and biochemical phenomenon. CASE: A 29-year-old woman, gravida 2, para 2, underwent right ovarian cyst excision after an abdominal ultrasound examination revealed a cystic mass of the right ovary. Histologically, the cyst was an immature cystic teratoma containing respiratory epithelium with mucous glands in the submucosa. Cytologic examination of the cyst fluid showed the presence of Curschmann's spirals. CONCLUSION: To the best of our knowledge, the formation of Curschmann's spirals associated with an immature cystic teratoma has not been previously reported. In this situation, the presence of spirals could be explained by formation from mucus normally found in that environment.

Adult↗

PubMedDate not supplied

Calcium oxalate crystals in benign cyst fluid from the breast. A case report.

BACKGROUND: Two types of calcification have been observed in breast lesions. The more common is composed mostly of calcium phosphate and is detected in routine histologic tissue sections of frequently malignant lesions. The rare type is calcium oxalate and is found exclusively in benign cysts. CASE: In a 47-year-old female, strongly birefringent polyhedral crystals of calcium oxalate were detected in benign breast cyst fluid. CONCLUSION: Calcium oxalate is not clearly visible on routine histologic sections, and examination of the cytologic specimens under polarized light reveals them. Awareness of this potential pitfall might lead to conservative management.

Biopsy↗

PubMedDate not supplied

Inflammatory pseudotumor of the uterus: a case report.

We herein report a case of inflammatory pseudotumor of the uterus, which is a very unusual site for the lesion. To the best of our knowledge, only 2 cases of inflammatory pseudotumor of the uterus have been reported.

Diagnosis, Differential↗

PubMedDate not supplied

Bilateral breast masses and bloody nipple discharge in a two year-old boy.

Breast enlargement with bloody discharge is very rare in childhood. We report a two year-old boy with breast enlargement and bloody discharge. Because of persistent bloody discharge, subcutaneous mastectomy was performed. The specimen showed histologic changes identical to those seen in adult mammary duct ectasia. We suggested that the infant's own endocrine system is responsible for breast enlargement and mammary duct ectasia, possibly occurring as a result of a mechanism similar to that in adults.

Blood↗

PubMedDate not supplied

Cartilaginous hamartoma of the chest wall with secondary aneurysmal cyst-like areas in an infant: a case report.

A case of a four-month-old infant diagnosed as cartilaginous hamartoma of the rib is presented. This rare tumor usually presents at birth. The patient had respiratory distress syndrome. Swelling of the ribs was palpable on physical examination and the infant underwent surgery for excision of the ribs. Histopathologically, the tumor showed benign focal overgrowth of normal skeletal elements with cartilaginous, vascular and primitive-appearing mesenchymal elements. Additionally, secondary aneurysmal cyst formation coexisted with the tumor. The diagnosis was infantile cartilaginous hamartoma of the rib. In this entity, primitive-appearing mesenchymal stroma may be mistaken for a malignant condition. Usually a benign clinical course is expected and treatment is by block excision.

Biopsy↗

PubMedDate not supplied

Effects of prenatal ethanol exposure on neuronal migration, neuronogenesis and brain myelination in the mice brain.

BACKGROUND: One of the most severe consequences of maternal alcohol consumption is the damage to the developing central nervous system. MATERIAL AND METHODS: To evaluate the effect of prenatal alcohol exposure on neuronal migration, neuronogenesis and myelination in the brain, pregnant BALB/C mice were maintained on either liquid diets containing ethanol (12 g/kg body weight) beginning on gestation day 6 or isocoloric diet (control group). The dams were sacrificed on gestation day 17 and the brain sections of the pups were analyzed using immunohistochemical method to evaluate the number of neurons, oligodendrioglial expression of myelin basic protein (MBP) and neuronal expression of neural cell adhesion molecule (NCAM). RESULTS: Ethanol-exposed pups revealed significantly weaker expression of MBP compared to the control group. In contrast, no significant difference of NCAM expression and neuronal cell count were present between ethanol-exposed pups and the control group. CONCLUSION: These data demonstrate that alcohol exposure affects the level of MBP expression, consequently causing a reduction in brain myelination that may lead to neuronal dysfunction. The ineffectiveness of prenatal alcohol exposure on the number of neurons in contrast to the previous reports might be due to the adequate sampling of areas for cell counting. Although there is a view that NCAM is involved both directly and indirectly in neuronal cell migration, we speculate that alcohol neuroembryotoxicity uncouples this relationship. Other adhesion molecules, such as L1, or extracellular matrix proteins, such as laminin, would be other candidates for investigation.

Animals↗

PubMedDate not supplied

Familial arthropathy with camptodactyly: reports of two families.

Familial association of congenital camptodactyly and arthropathy without evidence of concurrent inflammation has an autosomal recessive pattern of inheritance. We describe four children born to consanguineous parents in two families with congenital camptodactyly and polyarthropathy which were misdiagnosed and treated as juvenile rheumatoid arthritis (JRA) for some time. The siblings in the second family also had fibrosing pleuritis. Histopathological examination of the synovial tissues of the children in the first family revealed synovial hypertrophy and presence of multinucleated giant cells with minimal inflammation and vasculitis. On the other hand, prominent fibrosis with no inflammation was present in the synovial tissue of the elder boy in the second family. Thus, while the children in the first family had the phenotypic characteristics of congenital familial hypertrophic synovitis, the latter siblings probably represent a form of the familial fibrosing serositis.

Arthritis, Juvenile↗

PubMedDate not supplied

The prevalence of liver function abnormalities in pediatric celiac disease patients and its relation with intestinal biopsy findings.

UNLABELLED: Abnormal liver function tests and liver damage are seen frequently with celiac disease. However, the pathogenesis of liver functions abnormality is not clearly understood. The aim of this study was to determine the frequency of abnormal liver functions in children with celiac disease and its relation with anthropometric measurements and severity of intestinal damage. PATIENTS AND METHODS: Twenty seven patients with celiac disease were included in the study. Anthropometric and laboratory examinations and intestinal biopsies were performed in all the patients. Mucosal lesions were classified according to the Marsh classification. Villous area, crypt height and mitotic count were measured morphometrically for all biopsy samples. RESULTS: The mean age of patients was 6 +/- 5 years on admission. Alanine aminotransferase levels were normal (group 1) or elevated (group 2) in 20 and 7 patients, respectively. The mean alanine aminotransferase levels were 22.0 +/- 7.2 in group 1 and 70.5 +/- 31.1 U/L in group 2 patients, (p < 0.001). Complaints, mean age, height for age, weight for height, serum albumin level, villous area, crypt height and mitotic count were not significantly different between the two groups. Similarly, the ratio of Marsh classification was not significantly different between the two groups. All patients were given a gluten-free diet. Serum aminotransferase values returned to normal after 7.4 +/- 2.7 months of a gluten-free diet. CONCLUSION: Abnormalities of liver functions are frequently seen in paediatric celiac disease patients. These abnormalities are not correlated with malnutrition and severity of intestinal mucosal lesions. Liver enzyme activities return to normal levels in a few months after gluten-free diet.

Adolescent↗

PubMedDate not supplied

Nonimmune hydrops fetalis and bilateral pulmonary hypoplasia in a newborn infant with nuchal vascular hamartoma.

Nuchal vascular hamartoma was found in a newborn premature infant who presented with nonimmune hydrops fetalis, pulmonary hypoplasia due to bilateral pleural effusion and polyhydramnios in utero. The baby died 26 hours after birth despite maximal respiratory and circulatory support. Postmortem examination revealed a vascular hamartoma localized to the left posterolateral region of the neck. We suggest that nuchal vascular hamartoma may be associated with fetal hydrops, probably due to compromised lymph drainage.

Abnormalities, Multiple↗