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Biomedical subjects

E P Bekhtereva

Publications and source records attributed to E P Bekhtereva.

At least 19 recordsLinked to original sources
PubMed1980

[Pharmacological analysis of the role of dorsal hippocampus adrenergic effects in the central mechanisms of ovulation and compensatory ovarian hypertrophy in rats].

In experiments on mature female rats it was shown that L-DOPA administration restores normal ovulation in rats after the dorsal hippocampus destruction and related partial ovulation blockade. Pharmacological analysis after microinjections of alpha- and beta-adrenoblockers into the dorsal hippocampus region has shown that alpha- and beta-adrenoreception of the dorsal hippocampus plays a definite role in the regulation of gonadotropin secretion. However, the effect of phentolamine injection on the rat ovulatory reaction was less pronounced than under conditions of this hippocampus region destruction. The beta-adrenoblocker propranolol injected into the dorsal hippocampus inhibited compensatory hypertrophy of the ovaries in hemicastrated rats, decreased the hypophyseal FSH content and did not influence ovulation.

Animals↗
PubMed1978

The participation of monoaminergic central mechanisms on adenohypophyseal secretion.

In acute and chronic experiments in rats has been studied the action of drugs influencing central neuro-transmitter on the functional activity of hypophysis-adrenal and hypophysis-gonadal system. Evidence has been obtained that central neurotransmitters participate in the control of ACTH-glucocorticoids secretion. However, there is no clear correlation between noradrenaline and serotonin level in the brain and the degree of reaction of pituitary-adrenal complex to stimuli. Pharmacological analysis of nervous regulation of gonadotropic hypophysis function has revealed the significance of adrenergic mediation in the mechanism of feedback action of sex hormones and in the mechanism of limbic influences on hypothalamic regulation of gonadotropin secretion.

Adrenocorticotropic Hormone↗
PubMed1977

[Effect of sigetin on anovulation in rats].

The effect of sygethin on anovulatory cycle was studied in mature female rats. Anovulation was experimentally induced in rats on the one hand by stress effect (keeping rats in crowded conditions), and on the other hand by removing one ovary (hemicastration). Sygethin therapy (10 mg/kg for 4-5 days) proved to restore normal ovulation. When higher sygethin doses were used, and when it was administered for longer periods (for 2 to 3 weeks) no such effect proved to ensue. The results of these experiments suggest that small doses of sygethin stimulated luteinizing hormone secretion.

Animals↗
PubMedDate not supplied

[Effect of L-dopa on the gonadotropic function of the pituitary gland].

Chronic experiments were conducted on female rats. It was shown that administration of noradrenaline precursor l-DOPA in a dose of 20 mg/kg for a period of 2 weeks led to the premature sexual maturation of the sexually immature rats, depressed the estrus, but increased the percentage of ovulations in adult rats with a normal cycle, restored the ovulation in 50% of rats with irregular anovular cycle and altered the correlation of the sexual cycle phases and the FSH and the LH level in the hypophysis. Administration of l-DOPA to rats with a spontaneous estrus restored the normal sexual cycle and ovulation in them. Prolonged administration of l-DOPA; (for 3 to 4 weeks) in a dose of 20 mg/kg and also the use of higher doses (100 mg/kg) produced a depressive effect on the gonadotropic function of the hypophysis.

Animals↗
PubMedDate not supplied

[Effect of the nonhormonal bisanionic aromatic compound IEM 967 on the pituitary-ovarian system of rats].

A new original drug IEM-967 (a sulfoderivative in aromatic series with riged molecular structure) exhibited both stimulating and inhibitory gonadotropic effects, depending on reactivity of the system hypothalamus-hypophysis-gonads as well as on periods of the drug administration, in chronic experiments on rats. At the same time, the drug did not possess any peripheral estrogenic action on uterus and vaginal epithelium. The drug both resembled and had a number of differences and advantages as compared with the earlier synthesized compound sigetin in its effect on the gonadotropics function of hypophysis. Synthesis and study of effective medicinal agents causing selective effects on the gonadotropic function of hypophysis are of importance for obstetric and gynecological practice.

Animals↗