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Biomedical subjects

E P Gitel'

Publications and source records attributed to E P Gitel'.

At least 19 recordsLinked to original sources
PubMed2006

[The role of interleukins in the pathogenesis of atherosclerosis].

There is now doubt today that inflammation plays one of the key roles in the development of atherosclerosis. Numerous data demonstrate a connection between acute cardiovascular complications and laboratory signs of inflammation. There is a connection between signs of inflammation and an unfavorable prognosis in cardiovascular patients. Proinflammatory cytokines are divided into several groups: interleukins, interferons, tumor necrosis factors, colony stimulating factors, and hemopoietic cytokines. All these groups of cytokines are involved in the immune inflammation process in atherosclerosis.

Coronary Artery Disease↗
PubMed2006

[Development of renal affection in obese patients].

AIM: To characterize mechanisms, early markers and clinical signs of renal damage in obesity. MATERIAL AND METHODS: The trial covered 29 males aged under 50 years (mean age 37.7+/-9.3 years) with abdominal obesity having neither carbohydrate metabolism disturbances nor chronic renal disease. All the patients were examined for microalbuminuria (MAU), serum level of leptin. Radionuclide scintigraphy of the kidneys with an acute captopril test, tests for serum concentrations of endothelin-1, homocistein, uric acid, ultrasound dopplerography of the brachial artery for assessment of endothelium-related vasodilation (ERVD) were made in 24 patients. In 9 patients MAU and ERVD were estimated after 3 months of valsartan treatment (80 mg/day). RESULTS: MAU was detected in 62% patients, its rate increasing with elevation of serum leptin and endothelin concentration. Under normal values of creatininemia and GFR, obese patients showed deletion of renal functional reserve (RFR). Patients with low RFR had maximal uricemia and homocysteinemia, serum endothelin-1. Such patients demonstrated also abnormal ERVD. 3-month valsartan intake led to elevation of ERVD and disappearance of MAU. CONCLUSION: Excessive leptin registered in obese patients provoked dysfunction of the endothelium of the intrarenal vessels manifesting with MAU, growth of endothelin-1 serum concentration and disorder of ERVD. This leads to unfavourable changes in filtrating function of the kidneys as seen from gradual deletion of RFR in the absence of hypercreatininemia. Elimination of MAU and ERVD disorders in obesity can be achieved by administration of angiotensin II receptor blockers.

Adult↗
PubMed2002

[Comparative analysis of serum analyte level measurements by commercial diagnostic kits from four manufacturers (Alkor-Bio, Roche, Diagnostic Products Corporation-DCP, and Bayer Corporation)].

Hydrocortisone, progesterone, testosterone, triiodothyronine, thyroxine, chorionic gonadotropin, prolactin, alpha-fetoprotein, luteinizing, follicle-stimulating, and thyrotropic hormones were measured in human sera and in Lyphochek Immunoassay Plus Control reference sera (Bio-Rad Laboratories, USA) using 4 commercial kits (Alkor Bio Inc. and Roche, automated analyzer Roche Cobas Core; DPC, automated analyzer Immulite; Bayer, automated analyzer ACS:180). Coordination and correlation between these kits was observed, the coordination decreasing in the series Alkor Bio/Bayer, Alkor Bio/Roche, and Alkor Bio/DPC.

Hormones↗
PubMed2002

[Acute coronary syndrome without elevation of the ST segment: prognostic significance of determining the levels of troponin I and CPK-MBmass].

AIM: To assess diagnostic and prognostic role of CPK-MBmass and troponin I(TnI) in patients with acute coronary syndrome without persistent ST segment elevation (ACS). MATERIAL AND METHODS: Standard laboratory and device tests, measurements of CPK-MBmass and TnI levels at admission, 12 and 24 hours after hospitalization were performed in 51 ACS patients (33 men, 18 women, mean age 63 +/- 8.2 years). Early and late (1 month and 6, 12 months after hospitalization, respectively) complications were studied. RESULTS: The analysis of the immediate outcomes has revealed that treatment brought about stabilization of the condition in 45 (88.2%) patients, 6 patients had myocardial infarction within a month since the disease onset, one patient died. Late MI developed in 6 patients. For 6 months 2 more patients died. One patient died in the following 6 months. Thus ACS points to adverse 1-month prognosis in 12 and 1-year prognosis in 23.5% patients. TnI levels and CPK-MBmass are sensitive and specific for an adverse outcome in 91.7 and 100%, 82 and 89.7%, respectively. A predictive value for positive outcomes was 61.1 and 75%, respectively, for negative results 96.9 and 100%, respectively. CONCLUSION: Estimation of CPK-MBmass and TnI is essential in diagnosis of non-Q-wave MI and is predictable in relation to both short- and long-term prognosis.

Acute Disease↗
PubMed1999

[Clinico-laboratory algorithms for assessing the functional activity of the thyroid gland].

Three diagnostic algorithms making use of automated chemiluminescent analyzers are proposed for evaluation of the thyroid function, depending on the clinical situation. Laboratory criteria of hypothyrosis and thyrotoxicosis therapy monitoring are discussed. Main variants of disagreement between clinical data and values of thyrotropic hormone and free T4 are presented.

Algorithms↗
PubMed1996

[Topical diagnosis of pancreatic insulinomas].

Diagnosis of pancreatic insulinomas has been performed. Celiacography appeared to be the most efficient diagnostic method (more than 50% of sensitivity). Intraoperative ultrasound testing, that have been done in 16 patients, managed to make a topical diagnosis with a high accuracy and to evaluate relation of a tumor with portal vessels and pancreatic duct that is very important in choosing a proper surgical technique.

Adult↗
PubMed1995

[Effects of a number of cytokines on the proliferation of mesangial cells and the production of extracellular matrix in anti-GBM nephritis].

The interaction of IL-1 and TNF alpha in the autolous phase of anti-GBM nephritis was studied. The influx of mononuclear leukocytes into the glomerulus and high cytokine levels induced a decrease in mesangial cell proliferation and an increase in extracellular matrix production. The methylprednisolone suppression of mononuclear leukocyte infiltration caused the autocine cytokine secretion of mesangial cells. Cyclophosphamide decreased cytokine production, but did not affect mononuclear leukocyte infiltration. The absence of mononuclear leukocytes in the site of the injury induced by imbalance between the synthesis and degradation of extracellular matrix components. The uncontrolled metabolism of the extracellular matrix may be induced glomerulosclerosis.

Animals↗
PubMed1994

[The endocrine status of men with lupus nephritis].

Renal function was assessed in 8 males at reproductive age suffering from lupus nephritis (LN). Normal renal function was registered in 5 patients, hypofunction in 3 males. Endocrinological examinations (evaluation of secondary sexual characters, of hypophyseal and sex hormone profile, sexological questionnaires, spermograms) failed to distinguish significant differences between SLE males and renal patients without SLE suffering from hypogonadism (13 males with uremic hypogonadism, 10 males with azoospermia induced by cytostatics). Endocrinological changes revealed may result from uremia and immunodepressive therapy. In 5 patients these abnormalities were corrected by parlodel and zinc sulfate. The authors came to the conclusion that feminization is not universal in LN males.

Adolescent↗
PubMed1993

[The possible approaches to the theoretical validation of the use of cytostatics and corticosteroids in treating glomerulonephritis].

Cyclophosphamide (CP) and methylprednisolone (MP) were tried on rats with experimental nephrotoxic serum nephritis and mice with experimental acute serum nephritis. Pathological processes were analyzed simultaneously in vivo and in vitro. CP reduced the antibody impairment and stimulated glomerular infiltration by mononuclear leukocytes whose mediator spectrum was oriented to repair. MP failed to stop the impairment and aggravated the infiltration. The resultant chaotic accumulation of the extracellular matrix raised the risk of sclerosis. CP showed the advantages in experiment demonstrable also in the clinical setting.

Adrenal Cortex Hormones↗
PubMed1993

[Nephropathy-related disorders of physical and sexual development in girls: experience with successful stimulation by zinc, parlodel and norcolut].

The paper reports 3 cases of physical and sexual retardation in girls aged 14-22 with nephropathy: 1 girl had uremia in a conservative stage, 1 patient was put on a chronic hemodialysis for terminal uremia, 1 girl received a renal transplant. In response to combined treatment (zinc sulfate+parlodel) in the former two patients and norcolute therapy in the latter one body mass and growth increased in all the 3. The discussion is concerned with mechanisms of developmental defects in nephropathies, comparative efficacy of the drugs used and social rehabilitation of nephropathy girls with small height and sexual infantilism.

Adolescent↗
PubMed1991

[Pathospermia in patients with glomerulonephritis and rheumatoid arthritis treated by immunodepressants: the possibilities of its correction with zinc and parlodel].

Two groups of patients aged 16.5-31 years with pathospermia given immunodepressants (IDS) for glomerulonephritis (group I) or rheumatoid arthritis (group II) before and/or at the moment of examination were examined. Five out of 6 patients of group I and all the patients of group II showed azoospermia. As a result of the treatment with zinc (30-90 mg of elementary zinc a day) and parlodel (2.5 mg/day) for 2-23 months, spermatogenesis improved or returned to normal in 2 patients of group I and in 2 patients of group II. It should be mentioned that out of 8 patients who turned out refractory to the treatment, 7 received glucocorticoids and cytostatics (CT) whereas among those who responded to the treatment, only 2 patients out of 4 were given CT. The reported data on the gonadotoxic dose of CT are discussed. The conclusion is made about the necessity of carrying out active treatment policy for pathospermia in patients who received IDS.

Adolescent↗
PubMed1990

[Immunoenzyme analysis of insulin antibodies in human blood serum].

Indirect solid-phase enzyme immunoassay (EIA) was used for the titration of antibodies to insulin in human blood sera. The modification suggested by the authors permits assessing the immunoglobulins G and M insulin-binding ability. The technique was optimized for all the stages of analysis and a method for estimating the insulin-binding ability of IgG in the sera diluted 1:80 and of IgM in the sera diluted 1:320 was developed. Fifty blood sera of patients with insulin-dependent diabetes mellitus were analyzed. EIA results were in good correlation with the findings of radioimmunoassay.

Diabetes Mellitus, Type 1↗
PubMed1990

[Distribution of labeled amino acids and delta-sleep inducing peptide in the body after instillation into the conjunctiva of the rabbit eye].

Dynamics of 3H-valine, 3H-glycine and 3H-DSIP distribution in various brain structures, tissues and liquids of an organism due to administration of these substances in eye conjunctive were studied in rabbits with scintillation spectrometry method. Marked amino acids and DSIP were observed in all substrates in 10 min after administration. Maximal activity was found in 2 h in the brain visual cortex and in 30 min in cardiac tissue, spleen and optical chiasma.

Amino Acids↗
PubMed1990

[Plasma levels of various gastrointestinal polypeptides in patients with cholelithiasis and different degree of functional disorders of the major duodenal papilla].

Findings of dynamic cholangiomanometry with the analysis of the tension curves are overviewed. This technique helped reveal different functional ailments of the bile papilla in major variants of the cholelithiasis course (acute obstructive++ cholecystitis, recurrent pancreatitis, and choledocholythiasis with obstructive jaundice). Parallel radioimmunoassay-based studies of a series of gastrointestinal polypeptides (insulin, glucagon, gastrin, vasoactive peptide, bombesin , and somatostatin) were conducted to determine the importance of these polypeptides in the pathogenesis of cholelithiasis complications. The levels of certain polypeptides were found to be related to the clinical manifestations of the disease. The complex assessment of the bile papilla function and gastrointestinal polypeptide concentrations offers a possibility for elaborating the pathogenetically relevant methods of therapy for this group of diseases.

Adult↗