Biomedical subjects
Publications and source records attributed to E P Konovalov.
The results of complex treatment of 37 patients operated on for the various acute abdominal surgical diseases were presented. Among them 22 patients for locally treated 0.02% antiseptical solution Decametoxin were used. Positively impact clinical course of the diseases reducing their purulent and septic morbidity rate in particular were evidenced separately in the patients operated on for acute necrotic pancreatitis.
The most important teoretical aspects of the enteral insufficiency syndrome formation in an acute abdominal surgical diseases were suggested. Basing on the treatment results analysis of 19 patients with different abdominal surgical diseases, using hypertonic sorbitol solution, the authors confirm high therapeutic efficacy of the preparation, administration of which have had promoted the intestinal motor function restoration and optimization, as well as adapting action of the preparation in enteral probe nutrition conduction in patients during ealy postoperative period.
The data, obtained as a result of the protective systems state (immunity, hemostasis, organism natural resistance) investigation in 20 patients with complicated course of necrotic pancreatitis, are adduced. There was determined, that the lowering of the oxygen dependent and oxygen independent functions of neutrophils, the lysosomic cationic proteins content correlates significantly with course of diseases severity. High concentration in the blood serum of anti-inflammatory cytokines (the leucocytes depression phenomenon) in combination with the oxygen dependent and oxygen independent function of phagocytes depression constitutes the criterion of complicated and unfavourable course of necrotic pancreatitis. Theoretical substantiation of the results is presented.
While application of dynamical omentopancreatopexy for the treatment of necrotic pancreatitis there were noted the purulent and visceral complications frequency lowering from 3.34 in every patient--while the closed interventions usage down to 2.02 and of mortality--from 57.2 down to 33% accordingly.
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The literary data and own observation of pulmonary microlithiasis, an extremely rare disease, are presented. The results of investigation of local immunity in patients were depicted.
A test group of 40 patients and a control group of 20 matched controls with pulmonary cancer and suppuration were exposed to preoperative and postoperative electromyostimulation (EMS) with adjuvant intravascular laser radiation of the blood (ILRB) to prevent thromboembolism versus conventional chemotherapy, respectively. At the preoperative examination all the patients exhibited secondary immunodeficiency. It was found that introduction of EMS and ILRB corrects immunity and activates fibrinolysis. A positive trend in coagulation is also attributed to immunomodulating effects of EMS and ILRB.
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Resulting from the electrocardiographic investigations in dynamics, in 7 patients with purulent-inflammatory complications of surgical diseases of the abdominal organs, the positive effect of intravascular laser irradiation of the blood on the function of cardiovascular system is shown.
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On the basis of the analysis of changes in the immunologic and biochemical parameters, the rational conditions of intravascular laser irradiation of the blood in treatment of purulent-septic diseases is suggested.
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