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Biomedical subjects

E P Laurence

Publications and source records attributed to E P Laurence.

3 recordsLinked to original sources
PubMed1995

Relative effectiveness of topical ketorolac and topical diclofenac on discomfort after radial keratotomy.

Two prospective, randomized, double-masked studies were conducted evaluating the analgesic effect of topical eyedrops after radial keratotomy (RK). One study of 117 consecutive initial RK procedures compared topical ketorolac (Acular) with topical diclofenac (Voltaren), and another study of 23 consecutive initial RK procedures compared topical ketorolac with a control medication (HypoTears). Topical ketorolac was significantly more effective than the control but not significantly different from topical diclofenac. The onset of analgesic effect of these topical nonsteroidal anti-inflammatory drugs is longer than one hour. The analgesic effect of oral acetaminophen #3 significantly augments that of topical diclofenac drops for those experiencing any discomfort by six hours after surgery.

Administration, Topical↗
PubMed1994

Effect of topical diclofenac solution on discomfort after radial keratotomy.

The eyes of 65 consecutive radial keratotomy patients were treated topically with either diclofenac sodium 0.1% (Voltaren) solution or with Tears Naturale (control group) preoperatively and postoperatively in a prospective, randomized, double-masked study. During the first postoperative day, patients completed a questionnaire on discomfort level present at 15 minutes and at one, three, six, and 18 hours after surgery. Patients treated with topical diclofenac were generally more comfortable than patients in the control group. They had a significantly lower rate of "moderate" or "severe" discomfort and a higher rate of less than "mild" discomfort. Peak discomfort occurred at three hours in both groups. The prescribed optional oral analgesic was taken by 48.5% of patients in the diclofenac group and by 71.9% of those in the control group.

Diclofenac↗