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Biomedical subjects

E P Lykouras

Publications and source records attributed to E P Lykouras.

8 recordsLinked to original sources
PubMed1982

Short-term social prognosis of schizophrenia.

Two groups of schizophrenic patients with diametrically opposed illness outcomes were compared, 14 months after discharge, with respect to 21 parameters. The first group comprised patients who relapsed and were readmitted into hospital and the second group comprised patients who achieved satisfactory occupational rehabilitation in the community. Satisfactory occupational rehabilitation was positively associated and relapse was negatively associated with the following parameters: compliance to maintenance pharmacotherapy, satisfactory work record, compulsory admission into hospital, living apart from parents or spouse after discharge, illness precipitated by stressful events, longer duration of hospitalization and more advanced age at onset of illness. The authors express the view that awareness of the parameters influencing short-term social outcome might contribute to a more efficient management of schizophrenic patients.

Adult↗
PubMed1982

Abrupt lithium discontinuation in manic-depressive patients.

Prophylactic lithium was abruptly discontinued (under double-blind conditions and using placebo) in 18 manic-depressive patients for 15 days. Following lithium withdrawal tremor of hands, polyuria, general muscular weakness, polydipsia and dryness of mouth were significantly reduced. No withdrawal symptoms were noted. Three patients relapsed within 4 days of lithium discontinuation. The questions arising from these findings are discussed and the possibility of a rebound phenomenon produced by lithium is considered.

Adolescent↗
PubMed1981

Histochemical changes of peripheral blood leukocytes during lithium treatment.

The effect of lithium on the histochemistry of blood granulocytes was studied in 16 manic-depressive patients during lithium prophylaxis. Blood smears obtained before, at 2 months and at 12 months after initiation of treatment showed that lithium caused condensation of the chromatin in granulocytes, conformation changes in eosinophilic granules and the disappearance of basic proteins found in the cytoplasm of eosinophils in the drug-free patients. The latter findings are interpreted as indicating the involvement of lithium in histamine metabolism.

Adult↗
PubMed1981

Sleep deprivation psychoprophylaxis in recurrent affective disorders.

Administration of prophylactic 36 h total sleep deprivation to 9 manic-depressive patients (5 bipolar and 4 unipolar depressives) reduced the frequency of relapses and increased the duration of normothymia in 5 patients, left the course of illness unchanged in 3 patients whilst in 1 patient the effect could not be evaluated. Sleep deprivation appeared to be more effective in women, 'rapid cyclers', patients with a positive family history of mental illness and patients with recurrent depression. These observations confirm previous impressions and suggest a possible prophylactic effect of sleep deprivation.

Adult↗
PubMed1979

Affective disorders and ABO blood types.

Results of the present study provide evidence of: 1) a positive association between bipolar affective disorder and blood type O and a corresponding negative association between the former and blood type A, 2) a positive association between unipolar affective disorder and blood type O, and 3) a positive association between involutional depression and blood type A and a corresponding negative association between the former and blood types B and O. Sex does not appear to modify the ABO blood types' distribution in patients with bipolar, unipolar affective disorder, or involutional depression, and the same holds for early- or late-onset of the illness in patients with bipolar or unipolar affective disorders. Findings in the present study do not support the validity of the bipolar-unipolar distinction of affective disorders, and provide evidence in favour of the view that involutional depression is a genetically distinct nosological entity.

ABO Blood-Group System↗