Biomedical subjects

E P Pogorel'skaia

Publications and source records attributed to E P Pogorel'skaia.

4 recordsLinked to original sources

PubMed1985

[Regulating effect of bone marrow cells on human T-lymphocyte function].

A study was made of the regulatory effect of human bone marrow cells in two experimental systems: lymphocyte proliferation in response to PHA, and spontaneous and PHA-induced production of macrophage migration inhibition factor (MIF) by peripheral blood lymphocytes. It was shown that bone marrow cells inhibit the proliferative activity of stimulated peripheral blood lymphocytes and induced MIF production. The effect of bone marrow cells on spontaneous MIF production was found to be inconclusive.

Bone Marrow↗

PubMed1985

[Quantitative and functional evaluation of immunoregulating cells and natural killers in patients with aplastic anemia].

Cell-mediated immunity was studied in 11 patients with idiopathic aplastic anemia according to several parameters at a time. Analysis of the data obtained draws attention to the pronounced relative lymphocytosis, disordered balance of the immunoregulatory subpopulations of T lymphocytes (T mu and T gamma) associated with an appreciable increase in the number of cytotoxic T suppressor cells. The lowering of spontaneous and optimal Con A dose-induced production of leukocyte migration inhibition factor and deficiency of the activity of normal killers can be determined by potentiation of the suppressor activity of T lymphocytes or by the influence of factors produced by T suppressors. The goal-oriented correction of the high suppressor activity of T cells may appear promising in the complex of therapeutic measures used in the management of the patients' population with idiopathic aplastic anemia.

Anemia, Aplastic↗

PubMed1985

[Aplastic anemia after acute viral hepatitis].

The authors describe 4 patients with grave aplastic anemia that developed after acute virus hepatitis. In two cases aplasia occurred at the icteric period of hepatitis, in one during convalescence, and in one 5 months after the recovery from hepatitis. The counter electrophoresis technique failed to reveal the Australian antigen in all the 4 cases. Ninety per cent of patients out of over 200 reported cases of aplastic anemia that developed after acute virus hepatitis died. Of the 4 cases followed up by the authors, 3 patients died. One of the female patients was subjected to splenectomy 3 weeks after the occurrence of grave aplasia with fatty bone marrow with a purpose of immunodepression. Splenectomy entailed a considerable decrease in hemorrhagic diathesis. Later on the patient was treated with caprine antilymphocytic globulin. At present the patient is in a state of remission. The problems of the pathogenesis of aplastic anemia following acute virus hepatitis and potentialities of the disease treatment are under discussion.

Acute Disease↗

PubMed1984

[Effectiveness of the treatment of severe aplastic anemia (splenectomy and immunosuppression)].

The authors appraise the efficacy of the treatment of severe aplastic anemia by splenectomy, antilymphocyte globulin and cyclophosphamide. A total of 120 patients were placed under observation. Of these, 103 patients had a severe disease pattern, one hundred and 112 patients with aplastic anemia including 96 with a severe pattern were subjected to splenectomy. Of the 112 splenectomized patients, 78 (69.6%) are alive. Of the 96 patients with severe aplasia, 60 patients (62.5%) are alive. Of 43 deceased patients, 7 had been admitted to the hospital 2-12 days before death and had not been subjected to splenectomy. Three patients died shortly after splenectomy, 8 patients died at the second month after operation. During the first 6 months after operation 20% of the operated patients died, whereupon 10 more per cent of the patients died for 5 months. The patients who survived 10 months may happen to develop a complete or partial remission. Complete remission was attained in 18.8% of the patients, almost complete recovery in 17.7% of the operated, considerable improvement of the estimates was attained in 17.7% of the patients. Antilymphocyte globulin was administered to 23 splenectomized patients. The remission was attained in 6 patients, and 8 more patients improved. If the patients did not respond to the treatment with antilymphocyte globulin, or if they developed relapses, the authors administered cyclophosphamide. Of the 15 patients, 9 responded to the treatment (5 patients improved, remission was attained in 4 patients, 3 of whom are in a state of remission until now). On the 15 patients treated with cyclophosphamide 12 patients have been alive for not less that 2 years.

Adolescent↗