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Biomedical subjects

E P Strecker

Publications and source records attributed to E P Strecker.

At least 19 recordsLinked to original sources

[A new non-surgically implantable catheter port system for locoregional chemotherapy of advanced bladder cancer].

A new method to treat advanced urinary bladder cancer with locoregional chemotherapy has been developed which can be implanted by the radiologist. So far 3 patients with urinary bladder cancer invading the surrounding anatomical structures were treated. A 5F catheter is introduced into the internal iliac artery by the translumbar approach. Then, this catheter is exchanged with a coaxially assembled catheter port system over a guide wire. A subcutaneous tunnel through the puncture site is formed to receive the port. 10 mg mitomycin were infused three times at intervals of one to three weeks. Computed tomograms and cytoscopy showed complete disappearance of the tumour.

Aged

Flexible tantalum stents implanted in aortas and iliac arteries: effects in normal canines.

Vascular endoprostheses made of knitted tantalum wire and expanded over angioplasty balloons were placed into aortas or iliac arteries of 14 normal dogs. Twelve stents were placed into the infrarenal abdominal aorta and two stents in the left common iliac arteries by the left carotid artery approach. To firmly expand the stent against the vascular wall, nominal stent sizes 0.5-1.0 mm larger than the measured arterial diameter were required. Arteriography performed at specified follow-up intervals showed no evidence of thrombi or emboli; all side branches (lumbar arteries) covered by the stents remained patent. Vascular diameter decreased minimally at 8 and 26 weeks, associated with histopathologic evidence of neointimal buildup. This buildup was highest at 8 weeks (mean, 313 microns) and was slightly less at 26 weeks (mean, 223 microns). Almost complete coverage by endothelium was seen as early as 3 weeks. It is concluded that the flexible tantalum wire stents are well tolerated by the arterial wall and become quickly endothelialized. No excessive neointimal buildup was observed during the 6-month study.

Animals

Expandable tubular stents for treatment of arterial occlusive diseases: experimental and clinical results. Work in progress.

The balloon-expandable vascular prosthesis consists of a flexible, knitted tantalum wire mesh tube. To demonstrate its pliability, this prosthesis was tested experimentally in 10 mongrel dogs by implanting it into the proximal femoral arteries. The maximum follow-up time was 1 year. On the basis of the experimental results, in which there was no relevant stenosis, occlusion, or migration of the vascular prosthesis, nine patients were treated: one with iliac artery occlusive disease and eight with superficial femoral artery (SFA) occlusive disease (four reocclusions after angioplasty and four unsatisfactory primary angioplasty results). One SFA lesion was treated with the crossover method from the contralateral side. All implants remained patent without hemodynamically significant stenoses, with the longest observation time being 6 months. Flexible, expandable vascular prostheses are promising adjuncts to angioplasty.

Aged

Tantalum vascular stents: in vivo evaluation with MR imaging.

Magnetic resonance (MR) imaging at 1.5 T was performed on tantalum vascular stents placed in the aortas of six dogs. The stents produced no significant artifact and allowed for clear depiction of the aortic lumina as flow-void zones with spin-echo imaging and as high-signal areas with gradient-echo imaging. The MR findings correlated with the angiographic studies of the stented vessels. These results demonstrate the feasibility of MR imaging as a noninvasive means of evaluating vessel patency in the presence of tantalum vascular stents.

Animals

Influence of an ionic and a nonionic (sodium meglumine diatrizoate and iopromide) x-ray contrast medium of hemorrheology.

In two groups of ten patients each, an ionic and a nonionic contrast medium was injected intravenously, for digital subtraction angiography of the supra-aortic branches, to examine the influence of hemorrheologic properties. Afterward, blood samples were obtained through a central venous catheter and evaluated by a new instrument (oscillating capillary rheometer and densitometer). The viscous and elastic components of the complex blood viscosity and the hematocrit decreased after injection of ionic and nonionic contrast media. A statistically significant difference between the patient groups could not be found. The evaluated results describe an improvement of the hemorrheologic properties after contrast media injection.

Angiography

[Percutaneously implantable balloon-inflatable vascular prostheses. Initial clinical results].

Restenosis and occlusion of atherosclerotic arteries are prevented by a newly developed arterial prosthesis consisting of a pliable and elastic wire mesh tube positioned to the balloon of an angioplasty catheter. As the balloon is inflated the prosthesis dilates and provides the arterial wall with a new mechanical support. This new device was successfully implanted in ten patients having an iliac artery stenosis and improved the therapeutic result of the preceding angioplasty. There were no complications.

Aged

[Experimental research with a new percutaneously insertable and expandable vascular prosthesis].

Restenosis and occlusion are the most common reasons why transluminal balloon angioplasty may fail to provide long-term benefit. To prevent restenosis and occlusion of diseased arteries after angioplasty an arterial endoprosthesis has been developed which is positioned to the balloon of an angioplasty catheter and which consists of a stainless steel pliable and elastic tube. With the inflation of the balloon the endoprosthesis will dilate and give the arterial wall a new mechanical support. This new device has been implanted in 12 experimental dogs in arteries of different size and lumen. The longest patency rate of nine months was observed with the completely developed method.

Angioplasty, Balloon

Indications and use of abdominal angiography in trauma.

A series of 148 angiographic examinations in patients with blunt abdominal trauma have been reviewed. The major indications for arteriography were: (1) manifestations of shock in conjunction with clinical signs of abdominal injury; (2) the necessity for differentiation of multiple abdominal injuries; and (3) clinical signs of delayed rupture. Few false positive or false negative results were noted. The typical angiographic findings are discussed.

Abdominal Injuries

[Indications and value of treatment by catheter occlusion (author's transl)].

The value of the catheter occlusion therapy is analyzed in 92 cases retrospectively, and the indication, and complication risk of these procedures are considered. In the following vessel areas occlusion with different methods have been performed with decreasing frequency; kidneys, pelvis, legs, gastrointestinal tract, external carotid and internal carotid artery. Serious complications have been observed in therapeutic investigations at the head, especially in occlusions of the external carotid artery. In this group embolisation therapy should be performed with strict indication only.

Adrenal Gland Neoplasms

[The effect of selective autoperfusion through an extracorporeal circulation on the formation of arterial collaterals. Animal experimental results (author's transl)].

In 11 mongrel dogs (10-15 kg) with ligated superficial femoral arteries the formation of collaterals induced by increased arterial pressure with an extracorporal circulation was studied. In general anesthesia a teflon tube was inserted into one deep femoral artery. The other end of this tube war introduced through the right carotid artery into the thoracic aorta and arterial blood was drawn by a peristaltic tube pump from the aorta to the femoral artery. Different arterial pressures created by the pump were used to perfuse this hind limb. After 40 minutes perfusion time with 200 mmHG pressure, there was marked increase of collateralization by the deep femoral artery. At the contralateral non treated side, only minimal development of collaterals was visualized. These angiograms demonstrate that collaterals are opened by increased pressure within a short time interval The experimental model might have clinical implisations and accelerate collateral formation in non-surgical treatment of arterial occlusive disease.

Animals

Inhalation bronchography using powdered calcium ioglycamic acid.

In 16 baboons, reproducible bronchograms could be achieved by inhalation of 400--800 mg of powdered calcium ioglycamic acid. Anesthesia, tracheal intubation, or premedication were not necessary. In patients and volunteers, the inhalation of the contrast medium dust caused strong cough. Local anesthesia allowed inhalation for about 10 minutes, which resulted in successful demonstration of the pharynx, larynx, and trachea with bifurcation. Lobular and segmental bronchi were demonstrated only after a longer inhalation time. The contrast medium was completely eliminated and did not cause any recognizable adverse reaction. Nonspecific inflammatory reaction of the bronchial mucosa was seen microscopically in baboons.

Adult

[Diagnostic problems in chest injuries (angiography) (author's transl)].

Roentgenography is the simplest and most reliable means to arrive at the diagnosis of chest injury. General roentgenograms are difficult to interpret as they tend to be technically imperfect. Fractures, emphysema, pneumothorax, accumulation of fluid can usually be ascertained directly; but the traumatic origin of changes in the pulmonary parenchyma or of an enlarged heart shadow cannot be reliably deduced from the X-ray appearance. It may provide some differential-diagnostic information but the correct interpretation of the findings depends on further observation. In 6-7% of severe chest trauma with vascular injuries and rupture of the diaphragm angiography is indicated. The evidence to be obtained from chest radiography should not be overestimated: fractures of ribs are sometimes overlocked, even by the expert; parenchymatous lesions may manifest themselves as shadows but their nature remains obscure until they have been related to the clinical and subsequent radiological findings. The same applies to rupture of the diaphragm, bronchi or vessels, if only the immediate posttraumatic roentgenographs are examined. A tent-shaped heart shadow is considered characteristic of the presence of fluid in the pericardium; this is valid only for chronic hydropericardium, but not for the potentially fatal cardiac tamponade; if the pericardium has lost its elasticity a haemorrhage of not more than 150 ml may prove fatal. Nor does the roentgenogram provide information about pulmonary function. Especially in cases of pulmonary shock minor changes in the chest roentgenogram may give a false sense of security when, in fact, blood gas analyses show that a life-endangering situation has developed. The radiologist who is aware of the limititations of the method will derive maximum diagnostic benefit from a chest angiography. No other method is capable of supplying information of such great importance in such a short time.

Angiography

[Angiographic examinations of the stomach following Billroth II resections with special reference to the gastro-jejunostomy (author's transl)].

The arterial blood supply of the anastomosis in 6 stomach resected dogs (Billroth II) is examined by common angiographic technique in vivo, microangiography, and microscopy. In all animals there are at the site of the gastrojejunostomy bizarre tortuous vessels which cross the anastomosis. These arteries have a diameter between 50 to 2000 mu. They are newly formed vessels which cannot be demonstrated by common coeliaco- and mesentericography in animal experiments or in patients.

Angiography

Evaluation of the central canal of the spinal cord in experimentally induced hydrocephalus.

The central canal of the spinal cord has been proposed as a significant compensatory alternative pathway of cerebrospinal fluid (CSF) flow in hydrocephalus. Ten dogs were made hydrocephalic by a relatively atraumatic experimental model that simulates the human circumstance of chronic communicating hydrocephalus. The central canal was studied by histopathology and compared with 10 normal control dogs. In both groups the central canal of the spinal cord was normal in size, configuration, and histological appearance. In this experimental model dilatation of the canal and increased movement of CSF does not appear to be a compensatory alternative pathway.

Animals

[Aggressive aneurysmal bone cyst in childhood (author's transl)].

Case presentation of a four year old child with aggressive aneurysmal bone cyst of the fourth lumbar vertebra. Microscopic examination demonstrates a benign lesion. The roentgenographic pattern reflects a tumorlike bone destruction with signs of malignancy. Clinically, progression and invasion, similar to a semimalignant tumor, is noticed. The possible nature of this aggressive behaviour is discussed.

Aneurysm