Biomedical subjects

E Panitsa

Publications and source records attributed to E Panitsa.

3 recordsLinked to original sources

PubMed1998

Quality control of dose volume histogram computation characteristics of 3D treatment planning systems.

Detailed quality control (QC) protocols are a necessity for modern radiotherapy departments. The established QC protocols for treatment planning systems (TPS) do not include recommendations on the advanced features of three-dimensional (3D) treatment planning, like the dose volume histograms (DVH). In this study, a test protocol for DVH characteristics was developed. The protocol assesses the consistency of the DVH computation to the dose distribution calculated by the same TPS by comparing DVH parameters with values obtained by the isodose distributions. The computation parameters (such as the dimension of the computation grid) that are applied to the TPS during the tests are not fixed but set by the user as if the test represents a typical clinical case. Six commercial TPS were examined with this protocol within the frame of the EC project Dynarad (Biomed I). The results of the intercomparison prove the consistency of the DVH results to the isodose values for most of the examined TPS. However, special attention should be paid when working with cases of adverse conditions such as high dose gradient regions. In these cases, higher errors are derived, especially when an insufficient number of dose calculation points are used for the DVH computation.

Europe↗

PubMed1998

Developing a dose-volume histogram computation program for brachytherapy.

A dose-volume histogram (DVH) computation program was developed for brachytherapy treatment planning in an attempt to benefit from the DVH's ability to present graphically information on 3D dose distributions. The program is incorporated into a planning system that utilizes a pair of orthogonal radiographs to localize the radiation sources. DVHs are calculated for the volume of tissue enclosed by an isodose surface (e.g. half the value of the reference isodose). The calculation algorithm is based on a non-uniform random sampling that gives a denser point distribution at the centre of the implants. Our program was tested and proved to be fast enough for clinical use and sufficiently accurate (i.e. computation time of 20 s and less than 2% relative error for one point source, for 100,000 calculation points). The accuracy improves when a larger calculation point number is used, but the computation time also increases proportionally. The DVH is presented in the form of a simple graph or table, or as Anderson's 'natural' DVH graph. The cumulative DVH tables can be used to extract a series of indexes characterizing the homogeneity and the dose levels of the distribution in the treatment volume and the surrounding tissues. If a reference plan is available, the DVH results can be assessed relative to the reference plan's DVH.

Brachytherapy↗

PubMed1997

A method for measuring the ionization fraction due to the chamber wall (alpha) and assessing its characteristics.

To calibrate a megavoltage therapy beam using an ionization chamber, it is necessary to know the fraction of the ionization arising in the chamber wall when this is made of a material different than the medium. A method for measuring the ionization fraction produced by electrons arising in the chamber wall (alpha) is presented here. The method uses three measurements at the same point in a medium in order to calculate alpha. These measurements are made using the examined chamber with and without a buildup cap and one reference chamber of wall material equivalent to the medium (i.e., in our case, A1 and A-150 were used as wall materials for the examined and the reference chamber, respectively). Using this method, it is possible to calculate alpha in the medium for a series of irradiation conditions and assess its characteristics. Two main conclusions came out of this assessment. The first one is the independence of alpha from the wall material, even if this is aluminum (alpha is only dependent on wall thickness expressed in g cm-2). The second one is that alpha depends on the irradiation conditions; it increases with field size and depth.

Aluminum↗