Biomedical subjects
E Panitz
Publications and source records attributed to E Panitz.
Efficacy and cross-resistance studies on N, N'-bis (3,4 ditrifluoromethylphenyl) methylmalonamide, a novel anticoccidial agent.
N,N'-bis (3,4 ditrifluoromethylphenyl) methylmalonamide (Sch 18545) completely controlled a mild Eimeria necatrix infection at 50, 40 or 30 p.p.m. in the diet, and controlled E. tenella infections at 50 and 40 p.p.m. Slight oocyst passage was observed at each E. tenella treatment level with a marked increase at the 30 p.p.m. treatment level. Fifty p.p.m. were necessary to control E. acervulina infections; levels of 40 p.p.m. reduced E. acervulina oocyst production while 30 p.p.m. were ineffective. Evaluations of Sch 18545 using a mixed infection (Coccivac D) further suggested that activity with this compound was weakest against E. acervulina. Weight gains decreased with increasing concentration of drug in the diet of treated, infected birds and thus the compound showed an insufficient safety margin to be of practical value. Such 18545 administered at 35 p.p.m. in the diet was effective against amprolium, zoalene, aklomide or nicarbazin-resistant strains of E. tenella.
Anthelmintic activity of tioxidazole (Sch 21480) against gastrointestinal roundworms.
Methyl-6-propoxybenzothiazole-2-carbamate (tioxidazole) has broad spectrum activity against gastrointestinal nematodes.
An evaluation of ethyl-6-ethoxybenzothiazole-2-carbamate (Sch 18099) for anthelmintic activity in domestic animals.
Ethyl-6-ethoxybenzothiazole-2-carbamate (Sch 18099) was evaluated for efficacy against natural helminth infections in ponies, pigs, lambs and chickens. Sixteen critical trials were conducted in ponies at dosages of 15 to 150 mg/kg. At 15 mg/kg, efficacy against adult and larval Oxyuris equi was 100% and 91% and against small strongyles it was 98%. Efficacy levels were 95% against Strongylus vulgaris and S. edentatus at the 20 mg/kg dosage. In two trials at 100 mg/kg efficacy against Parascaris equorum was 77%. No efficacy was observed against Gastrophilus spp. or Anoplocephala spp. In swine single oral doses of 10 to 100 mg/kg were not effective. 500 ppm Sch 18099 in the diet for seven days resulted in 100% efficacy against Ascaris suum and Trichuris suis but had no effect on Stongyloides ransomi. Efficacy at 250 ppm against A. suum was 77%. Efficacy at 200 mg/kg in lambs was greater than 90% for Haemonchus contortus, Trichostrongylus axei, Marshallagia marshalli, Bunostomum trignocephalum, Oesophagostomum columbianum, Trichuris ovis, and Chabertia spp. Efficacy was less than 80% for Trichostrongylus vitrinus, Nematodirus filicollis, Ostertagia circumcinta and Cooperia curticei. Except for O. circumcinta and C. curticei, drug efficacy was reduced for these worms in lambs treated at 100 mg/kg. Efficacies of 14.3-89% against Ascaridia galli were obtained with dietary levels of 125-1000 ppm Sch 18099 fed for 7 days. Efficacy of 100% was recorded against Heterakis gallinarum at the 1000 ppm dietary drug level.
Antihistomonas activity of (5-nitro-1-thienyl)-n-acetylamine in experimental enterohepatitis of turkey poults.
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Anthelmintic effect of the gentamicin complex and coproduced antibiotics against tapeworms of lambs and cats.
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Effect of gentamicin on early mortality and later performance of broiler and Leghorn chickens.
Field and floor-pen trials demonstrated that subcutaneous injection of 0.2 mg gentamicin at one day old reduced bacteria-caused deaths in White Leghorn and broiler-type chicks. Growth, feed efficiency, and condemnation data from broiler trials suggested an advantage for treated chickens over unmedicated controls. Ninety-nine percent of clinical isolates were susceptible to gentamicin (10 mug) when tested by the modified Kirby-Bauer method. In vitro susceptibilities of these isolates to neomycin, nitrofurazone, chloramphenicol, and kanamycin varied from 90 to 94%. About half of the isolates were susceptible to dihydrostreptomycin or tetracycline in vitro, while less than 10% were susceptible to penicillin or clindamycin. In vitro tests to determine the lowest concentration of antibiotics required to inhibit the growth of 31 bacterial isolates demonstrated that less gentamicin is required than neomycin, spectinomycin, or oxytetracycline.