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E Papadopulos-Eleopulos

Publications and source records attributed to E Papadopulos-Eleopulos.

12 recordsLinked to original sources
PubMed1995

A critical analysis of the HIV-T4-cell-AIDS hypothesis.

The data generally accepted as proving the HIV theory of AIDS, HIV cytopathy, destruction of T4 lymphocytes, and the relationship between T4 cells, HIV and the acquired immune deficiency clinical syndrome are critically evaluated. It is concluded these data do not prove that HIV preferentially destroys T4 cells or has any cytopathic effects, nor do they demonstrate that T4 cells are preferentially destroyed in AIDS patients, or that T4 cell destruction and HIV are either necessary or sufficient prerequisites for the development of the clinical syndrome.

Acquired Immunodeficiency Syndrome↗
PubMed1995

Factor VIII, HIV and AIDS in haemophiliacs: an analysis of their relationship.

In this review, the association between the Acquired Immune Deficiency Syndrome (AIDS) and haemophilia has been carefully examined, especially the data that have been interpreted as indicating transmission of the human immunodeficiency virus (HIV) to the recipients of purportedly contaminated factor VIII preparations. In our view, the published data do not prove the hypothesis that such transmission occurs, and therefore HIV cannot account for AIDS in haemophiliacs.

Acquired Immunodeficiency Syndrome↗
PubMed1993

Is a positive western blot proof of HIV infection?

It is currently accepted that a positive Western blot (WB) HIV antibody test is synonymous with HIV infection and the attendant risk of developing AIDS. In this communication we present a critical evaluation of the presently available data on HIV isolation and antibody testing. This evidence indicates that: (1) the antibody tests are not standardized; (2) the antibody tests are not reproducible; (3) the WB proteins (bands) which are considered to be encoded by the HIV genome and to be specific to HIV may not be encoded by the HIV genome and may in fact represent normal cellular proteins; (4) even if the proteins are specific to HIV, because no gold standard has been used to determine specificity, a positive WB may represent nothing more than cross-reactivity with non-HIV antibodies present in AIDS patients and those at risk. We conclude that the use of antibody tests as a diagnostic and epidemiological tool for HIV infection needs to be reappraised.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Kaposi's sarcoma and HIV.

Recently published informed debate affords strong indication that in patients with the Acquired Immune Deficiency Syndrome, HIV cannot, directly or indirectly, be the cause of Kaposi's sarcoma. This paper provides reasons for disallowing a current alternative theory that Kaposi's sarcoma is due to an unidentified sexually transmitted infectious agent and proposes instead that Kaposi's sarcoma is the result of prolonged and repeated exposure to nitrites and/or semen. If this alternative hypothesis is strengthened by confirmation of its predictions then the relationship of HIV to Kaposi's sarcoma, one of the principal AIDS-associated diseases, becomes somewhat remote. This may facilitate a shift of emphasis and encourage the development of alternative therapies.

HIV Infections↗
PubMed1989

Importance of the redox state in vasoconstriction induced by adrenaline and serotonin.

The actin myosin system and the redox state have been implicated in a number of cellular functions and in many pathological conditions. To study the predictions of a new redox theory of actin-myosin interaction we examined the relationship between the redox state and vasoconstriction of rat aorta and dog basilar artery by adrenaline and serotonin. The results show that the contraction induced by these physiological agents can be inhibited and reversed by reducing agents.

Actomyosin↗
PubMed1988

Reappraisal of AIDS--is the oxidation induced by the risk factors the primary cause?

The emergence of AIDS as a recognizable disease, its epidemiology, the clinical and laboratory data and the way in which they have been interpreted to deduce the currently acceptable hypothesis of its aetiology and mechanism of transmission are critically examined. There is no compelling reason for preferring the viral hypothesis of AIDS to one based on the activity of oxidizing agents. In fact, the latter is to be preferred, since unlike the viral hypothesis it leads to possible methods of prevention and treatment using currently available therapeutic substances.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Carcinogenesis.

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Carcinogens↗