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Biomedical subjects

E Paran

Publications and source records attributed to E Paran.

44 records · Page 3Linked to original sources
PubMed1984

Li efflux in erythrocytes of pregnant women: comparison of rates and temperature dependence for detection of hypertension.

Two determinants of lithium efflux in erythrocytes were compared, in relation to pregnancy: (a) efflux rates at 37 degrees C; (b) efflux temperature dependence, expressed by the 'break' of Arrhenius plots. Eighteen women were studied both at term and after delivery. While efflux rates were changed markedly, from 0.87 +/- 0.07 to 0.56 +/- 0.05 mmol/ (IRBC h) at term and post-partum, respectively, the characteristic break temperature of each woman remained essentially constant during and after pregnancy. The property of temperature dependence is more suitable than efflux rates for differentiation of hypertension during pregnancy.

Adult↗
PubMed1983

Alpha 1-antitrypsin in acute myocardial infarction.

Alpha 1-antitrypsin serum levels were measured in 48 patients with acute myocardial infarction and in 19 control patients either with coronary heart disease without necrosis, or with neither coronary disease nor inflammation. Alpha 1-antitrypsin was significantly raised in the group of patients with acute myocardial infarction. As some patients individually showed no change in alpha 1-antitrypsin levels, however, they were divided into two groups according to the maximum serum levels attained. Patients with non-increasing levels of alpha 1-antitrypsin showed increased mortality and a higher incidence of cardiogenic shock, whereas reinfarction occurred more frequently in the group with high alpha 1-antitrypsin levels. Our findings may suggest that the course of a myocardial infarction is determined not only by the severity of the ischaemic event, but also by the response of the "acute" phase reaction" mechanism. We conclude that a failure of alpha 1-antitrypsin levels to increase after myocardial infarction may be associated with a worse clinical course.

Coronary Disease↗
PubMed1983

Klinefelter's and Takayasu's syndromes in one patient--a pure coincidence?

The patient is a classical case of Klinefelter's syndrome and has, in addition, pulseless disease. In angiography, the involvement of the subclavian arteries and its main branches, consistent with Takayasu's arteritis type 1, was demonstrated. It is a pure coincidence that the patient with a 47 XXY karyotype also has an illness that affects mostly women?

Aortic Arch Syndromes↗
PubMed1983

The role of the doctor-nurse team in control of hypertension in family practice in Israel.

In the 1960s and early 1970s, only 9.4% of all hypertensives in Israel were under control, due to a low rate of detection, a high dropout rate and a low rate of patient compliance. In the past seven years, a program of screening and careful follow-up of hypertensives in over 400 community clinics has been introduced, based on the active participation of clinic nurses in addition to that of family doctors. This program has been associated with a large increase in the number of detected hypertensives, a fall in the dropout rate, and a decrease in patient waiting time. In one study of 5,541 hypertensives treated initially by a doctor alone, and then by the doctor-nurse team, the number of treated hypertensives who were under control increased from 42.1 to 84.6%. The improvement in hypertension control has paralleled the reduction in cardiovascular disease in Israel.

Family Practice↗
PubMed1978

Serum dopamine beta-hydroxylase activity in acute cardiac disease.

The activity of dopamine beta-hydroxylase in the serum was measured in patients with acute cardiac disorders who were admitted to a coronary care unit. The activity of the enzyme on admission was similar in patients with acute myocardial infarction and in those with other conditions; on discharge, the activity was reduced significantly. Patients with myocardial infarction had the greatest fall in the activity of dopamine beta-hydroxylase. Patients with multiple signs of sympathetic hyperactivity had significantly higher values for the activity of dopamine beta-hydroxylase on admission. Pain was found to significantly increase the activity of the enzyme. These data confirm findings that the activity of dopamine beta-hydroxylase in the serum reflects the intensity of sympathetic activity. The factors contributing to the elevated sympathetic activity in some patients with acute myocardial infarction seem to be nonspecific, but because of the ominous nature of increased sympathetic tone in this condition, it could be advantageous to identify these patients.

Acute Disease↗
PubMedDate not supplied

Essential hypertension: improved differentiation by the temperature dependence of Li efflux in erythrocytes.

Kinetic and thermodynamic properties of red cell lithium (Li) efflux were examined in patients with essential hypertension; the maximal rate of Li efflux as affected by temperature was measured at the range of 12 degrees to 42 degrees C. Fifty-two patients with essential hypertension and 22 normotensives were studied. The mean Li efflux, both into sodium (Na) medium and Li-Na countertransport, was higher in hypertensive than in normotensive persons, but the distinction between the two groups was limited by extended scatter and overlap. The distinction could be markedly improved by determining the effect of temperature on Li efflux. While all the normotensives exhibited Arrhenius plots of Li efflux with a change in slope ("break") around 30 degrees C, the corresponding "break" for most (75%) of the hypertensives was about 20 degrees C. Consideration of both the rate and the temperature dependence of Li efflux further improved the differentiation of hypertensive patients. Analysis of normotensive offspring of hypertensives and of patients with secondary hypertension indicates that the temperature dependence of Li efflux may serve as a genetic marker for essential hypertension.

Adolescent↗