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Biomedical subjects

E Partlow

Publications and source records attributed to E Partlow.

4 recordsLinked to original sources
PubMed1991

Ancillary instruments for the video microlaryngoscope.

Two years of experience with the video microlaryngoscope has identified the need for ancillary instrumentation to take full advantage of the system's potential. The authors developed the following additions to video microlaryngoscopy: 1) a hinged mirror that may be articulated from its pistol grip handle; 2) a 4-mm 30 degrees or 70 degrees angled telescope for examination of subglottic areas not accessible by mirror examination; and 3) angulated laryngeal instrumentation that permits operation on previously obscured anterior anatomy. The authors also find that the video microlaryngoscope's distal view eliminates interference with visualization caused by the syringe during vocal cord injection.

Humans↗
PubMed1988

A highly polymorphic locus very tightly linked to the Huntington's disease gene.

The genetic defect in Huntington's disease (HD), an inherited neuropsychiatric disorder of unknown etiology, has not been defined. The discovery of linkage between HD and the DNA marker D4S10(G8) raised the possibility of isolating the disease gene on the basis of its chromosomal location, in addition to providing a limited presymptomatic test for the late onset disorder. But it has been difficult to isolate other DNA markers nearer to the HD gene, and this has hampered attempts to identify the disease locus and limited the applicability and accuracy of predictive testing. Recently, several new DNA markers from the region of the genome near the HD gene have been isolated using a directed cloning strategy. We describe here the characterization of one of these new markers, D4S95, a highly polymorphic locus which displays no recombination with the HD gene in the families tested. The high degree of polymorphism at this locus and its proximity to the HD gene make it extremely useful for predictive testing and as a new starting point for attempts to clone the disease gene.

Alleles↗
PubMed1987

Advantages of video endoscopy in pediatric aerodigestive tract disorders.

The naked eye examination of the larynx through the laryngoscope is inadequate for the examination of the minute anatomic structures and does not permit the visualization of the subglottic space or the trachea. A telescope coupled to a miniature television camera is advanced under precise visual control through the vocal cords and into the trachea. Oxygen is administered through the instrument to avoid fogging and provide diffusion oxygenation during the apneic phase. The procedure is safe, fast, and provides a simultaneous record. A vastly improved image allows the examination to be performed from the television screen. Electronic imaging has much to offer in the area of pediatric endoscopy. Video endoscopic examinations of the aerodigestive tract of 151 infants were successfully performed without any complications.

Child↗