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Biomedical subjects

E Patek

Publications and source records attributed to E Patek.

At least 19 recordsLinked to original sources
PubMed1985

Outcome of different treatment modalities in cervix carcinoma Stage IB and IIA. Observations in a well-defined Swedish population.

Stage IB or IIA carcinoma of the cervix in a nonselected series of 263 young (less than or equal to 40 years) women was managed with radiotherapy alone or in combination with radical surgery. When the tumor was detected in Stage IB, the 5-year survival rate was 81% in the radiotherapy group and 96% in the combined therapy group. The corresponding figures for Stage IIA were 74% and 66%, respectively. When lymph node metastases were present at operation, the 5-year survival rate was reduced. The reduction was relatively small in Stage IB, but was decreased from 83% to 27% in Stage IIA. The size of the tumor had prognostic impact on the survival rate. Residual tumor in the surgical specimens was likewise associated with poorer prognosis in Stage IIA. The prediagnostic duration of symptoms indicates that the longer the pretreatment time and higher the stage at diagnosis, the greater the likelihood of metastatic spread. Adenocarcinomas comprised 13% of the tumors in the series. Complications of treatment were few.

Adenocarcinoma↗
PubMed1982

The effect of cyproterone acetate on pituitary-ovarian function and clinical symptoms in hirsute women.

Ten hirsute women in fertile age were given 50 mg cyproterone acetate (CA) on day 5--14 and 50 micrograms ethinyl oestradiol (EE2) on day 5--21 except during the first treatment cycle when EE2 was given on day 15--21. The treatment lasted for 12 months. Clinical examination and hormone analysis were undertaken every third month. LRH tests were performed prior to treatment with CA in late follicular phase and after one week of administration of the drug. Subjective improvement of hypertrichosis was reported in 7 women, objectively a significant decrease in hair scores was observed. Short-term effects of CA alone included significantly decreased serum levels of oestrogens while FSH, LH, 4-androstene-3,17-dione and testosterone remained unaffected. Long-term administration of CA and EE2 resulted in significantly decreased serum levels of FSH, LH and oestrogens whereas 4-androstene-3,17-dione and testosterone were not affected. The gonadotrophin response to LRH did not reveal any significant difference before and after treatment. 4-Androstene-3,17-dione and testosterone did not change during the LRH tests but increased levels of oestrogens were observed at the end of the test during the CA treatment. Since CA alone causes decreased oestrogen levels without any suppression of the basal gonadorrohin levels, it is speculated that CA directly affects the ovarian steroid biosynthesis. On the other hand the adrenal androgens seem to be unaffected by the drug.

Adrenal Glands↗
PubMed1980

Microfluorometric grading of mammary tumors. A pilot study.

Material obtained from 24 women with benign and malignant breast lesions was subjected to comparative morphologic and cytophotometric DNA analysis. All the cases of benign tumors, as well as benign tissue samples obtained from tumor-containing breasts, exhibited DNA values corresponding to the diploid control value. The tumors classified as carcinoma in situ or highly differentiated invasive cancers (grade I) showed a distribution of the DNA values significantly different from the diploid control values. The tumors classified s grade II and III showed a shift to the "triploid" area or were totally aneuploid. The results of the present pilot study suggest that quantitative cytophotometric DNA analysis can be used for grading the malignancy of breast tumors in combination with conventional histologic examination. Additional studies of larger groups of women may yield further information on the microfluorometric grading of malignancy. Such studies may also contribute to the further development and use of automated methods of cytologic diagnosis.

Adult↗
PubMed1979

Quinacrine hydrochloride. Review and mode of action of an antimalarial, used as an occlusive agent for transvaginal human sterilization.

Quinacrine hydrochloride, mainly used as an antimalarial, has been used as a nontoxic chemosterilant in a transvaginal procedure in the human female. Clinical experiments indicate that Quinacrine acts as a powerful obstructive agent exclusively on the epithelium of the intramural portion of the tube without alterating the histology of the endometrium. The precise mechanism of Quinacrine's obstructive action on the mucosa of the uterotubal junction is unknown. Its possible mode of action is binding to epithelial DNA thus forming a clot of granulomatous tissue, as Quinacrine is known to form adhesions when used in the control of neoplastic effusions. Zinc is known to inhibit Quinacrine-DNA binding. The human endometrium, rich in Zinc is unaffected by Quinacrine, whereas the tubal cornua, with little Zinc promote the obstruction by Quinacrine DNA bondage. The procedure is effective in 90 per cent of the cases with two instillations of Quinacrine. Further studies are essential to find agents that would potentiate the action of Quinacrine on the human Fallopian tube epithelium.

DNA↗
PubMed1978

Recurrent hydatidiform mole. Report of a case with five recurrences.

A report on a patient having five consecutive molar pregnancies is presented. None of the pregnancies was associated with a fetus and all five hydatidiform moles were histologically benign. The treatment of recurrent moles is discussed and the literature concerning this problem is reviewed.

Adult↗
PubMed1978

Caesarean section. A clinical study with special reference to the increasing section rate.

At Huddinge University Hospital 539 Caesarean Sections (C.S.) were made among 8415 deliveries from October 1972 to June 1976, corresponding to an over all C.S. rate of 6.4%. Over these years the rate has increased from 3.5% in 1972 to 9.7% in 1976. The main increase was due to a higher incidence of abdominal deliveries in cases of imminent fetal asphyxia. The maternal complication rate and the neonatal morbidity rate were both 6.5 times higher and the neonatal mortality rate was 4.1 times higher in emergency than in elective surgery. There was neither any mortality nor any morbidity in infants delivered by elective C.S. from healthy mothers at term.

Adolescent↗
PubMed1977

Hydrosalpinx simplex as seen by the scanning electron microscope.

Five cases of hydrosalpinx simplex were studied by light microscopy and scanning electron microscopy (SEM). Comparison was made with normal fallopian tube epithelia. By light microscopy numerous ciliated cells as well as nonciliated cells were found in both hydrosalpinx and normal tubal material. In hydrosalpinx material the epithelium was found to be compressed to one-sixth its usual height. The SEM survey of large areas of hydrosalpinx did not reveal any deciliation. In fact, the mucosa of the hydrosalpinx did not differ conspiciously from that of a healthy fallopian tube. However, some nonciliated cells with collapsed areas were revealed by SEM. The significance of the compressed areas is unknown.

Adnexal Diseases↗