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Biomedical subjects

E Pawley

Publications and source records attributed to E Pawley.

6 recordsLinked to original sources
PubMed1990

Is vitamin D necessary for skeletal integrity in the elderly?

Serum 1.25 dihydroxyvitamin D concentrations were reduced in elderly patients with femoral neck fractures, irrespective of the presence of osteomalacia. This reduction was not attributable to a decrease in vitamin D binding protein. The low rate of bone turnover in these elderly patients might reduce the requirement for vitamin D and protect against the development of osteomalacia. Serum vitamin D metabolite concentration cannot be used as a screening test for osteomalacia in these patients.

Adult↗
PubMed1989

Changes in osteocalcin after femoral neck fracture.

In a group of elderly patients with osteoporosis and femoral neck fracture, osteocalcin concentrations rose significantly in the first week after fracture fixation. The changes in osteocalcin correlated well with the changes in plasma 1,25-dihydroxycholecalciferol (P less than 0.001).

Aged↗
PubMed1987

Osteomalacia and femoral neck fractures in the elderly patient.

In a series of over 1000 elderly patients with femoral neck fracture, who were routinely screened by iliac crest bone biopsy, a 2% prevalence of osteomalacia was found. This low figure suggests that osteomalacia is not a significant predisposing factor in the development of these fractures and that routine screening is not cost-effective.

Aged↗
PubMed1987

Screening for osteomalacia in elderly patients with femoral neck fractures.

In this study 201 elderly patients with femoral neck fractures were compared with 30 osteomalacic patients with the same injury. Hypocalcaemia and a raised alkaline phosphatase level are common biochemical abnormalities in elderly patients with femoral neck fractures. In only a minority of patients, however, were they associated with histologically proven osteomalacia. By using the combination of hypocalcaemia and a raised alkaline phosphatase it is possible to identify a subgroup (approximately 10% of all admissions) in whom osteomalacia is relatively likely.

Aged↗