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Biomedical subjects

E Peitersen

Publications and source records attributed to E Peitersen.

At least 19 recordsLinked to original sources
PubMed1986

Vestibular toxicity following netilmicin therapy in the neonatal period.

Thirty-seven children treated with netilmicin during the neonatal period were seen at follow-up at the age of 2-4 years to investigate for possible vestibular damage caused by netilmicin therapy. No definite vestibular damage could be found in these 37 patients, including three patients in whom greatly elevated serum concentrations of netilmicin had been measured. The present study confirms previous findings in adults showing a low ototoxicity of netilmicin.

Female↗
PubMed1984

Zinc therapy of acetazolamide-induced side-effects.

A double-blind cross-over trial extending over 4 weeks with administration of 0.2 g zinc sulphate 3 times daily and a placebo was carried out on 12 patients having grave acetazolamide-induced side-effects manifesting themselves as gustatory disorder, anorexia, and paraesthesia. All the patients had S-zinc levels within the normal range. These rose during zinc therapy periods, to fall again within placebo periods. Recording of the degrees of subjective side-effects based on interviews showed the side-effects to abate towards the conclusion of the trial period, independently of the randomizing programme. In other words, no significant difference was demonstrable between zinc period and placebo period. Taste tests according to Börnstein showed the gustatory disorders to be related exclusively to beverages containing carbon dioxide. However, in no more than 3 out of 10 patients did the gustatory sense return to normal after administration of zinc and one after placebo. Thus, this controlled trial has not served to disclose any statistically significant effect of zinc administration on acetazolamide-induced side-effects.

Acetazolamide↗
PubMed1984

Caloric testing with small temperature gradients. Caloric zero.

Caloric nystagmus was investigated in 50 normal subjects with stimulation of the temperatures 30, 33, 35, 39, 41, and 44 degrees C. Mean values of the duration and the eye speed of the slow phase of adjacent temperatures were significantly different. No difference could be demonstrated between the equidistant temperatures 30/44 and 35/41 degrees C, but the response was significantly stronger with 35 than with 39 degrees C. This indicates that the caloric zero, i.e., the theoretical neutral temperature, is higher than 37 degrees C. The caloric zero was determined by extrapolation of the regression lines of the mean values for the six temperatures investigated. Determination by means of maximum eye speed of the slow phase values showed to be more accurate than with the duration, probably due to smaller interindividual variations of the responses.

Adolescent↗
PubMed1982

The natural history of Bell's palsy.

The purpose of this investigation was to explain the spontaneous course of idiopathic facial palsy without treatment of any kind. The investigation included 1011 patients seen over a fifteen-year period. The patients were checked at short intervals until remission occurred, and these checks were discontinued only when normal function was restored or after a period of one year. For 85 percent of patients the first signs of remission were observed within three weeks after the outbreak; for the last 15 percent remission occurred three to six months later. Seventy-one percent recovered normal mimical function of the face, 13 percent had insignificant sequelae, and the last 16 percent had permanently diminished function with contracture and associated movements.

Adolescent↗
PubMed1981

Variations in tympanograms in children attending group-care during a one-year period.

During a 1-year period, 151 children, 1/2-6 years old, attending group care, were followed by monthly tympanometry in order to describe spontaneous variations in the tympanograms in relation to age and time of the year. Furthermore, the number of spontaneous variations during the year was assessed. Significantly more flat curves were seen in children 1/2-1 year old than in the older age groups, indicating a high frequency of spontaneous remission about the age of 2 years. In all age groups more normal tympanograms were seen during late summer than during the rest of the year. Spontaneous variations in the tympanograms were taking place 2.9 times (mean) during the period of observation. Correlation was found between the presence of catarrh and flat curves. Furthermore, in children greater than or equal to 3 years old, a correlation between case history signs of enlarged adenoids and flat curves lasting for 3 months or more was found. It was concluded that persistence of flat curves in children 1/2-1 (2) years old usually requires no treatment, as spontaneous remission can be expected, whereas persistence of flat curves for greater than or equal to 3 months in children greater than or equal to (2) 3 years old indicates that treatment (adenoidectomy) should be performed.

Acoustic Impedance Tests↗
PubMed1979

The effects of some drugs on the caloric induced nystagmus.

A striking difference between the two anticholinergic drugs was observed. Atropine only modified the eye speed of the slow phase (mes), whereas scopolamine modified both parameters measured, mes and duration. Amphetamine and caffeine prolonged the duration, leaving the mes unchanged. All antiemetic drugs inhibited both parameters. It is concluded that the effect of a drug on the caloric reaction gives insufficient information in the preclinical evaluation of vestibulo-suppressive drugs.

Amphetamine↗
PubMed1979

The effect of adenoidectomy on secretory otitis media in children.

139 patients, 80 boys and 59 girls aged 1 1/4--13 1/2 years suffering from serous otitis media based on otoscopy and tympanometry had adenoidectomy performed and no other surgical measures taken. The efficiency of the treatment was assessed 2--4 months later. Intially flat tympanometry curves were found in 155 ears, negative middle ear pressure in 70 ears and low curves in 20 ears. 78% of all ears and 73% of the ears with flat curves were seen to normalize during the observation periods.

Acoustic Impedance Tests↗
PubMed1979

The significance of the target frequency and the target speed in optokinetic nystagmus (OKN).

The significance of the frequency of the stimuli (target frequency) and the angular velocity of the stimuli (target speed) on horizontal optokinetic nystagmus (OKN) was investigated in 6 normal human subjects using target frequencies from 1/3 Hz to 24 Hz and target speeds from 5 degrees/sec to 120 degrees/sec. Regularity and reproductiveness of the OKN were obtained only in test conditions where each transit of targets was followed by an optokinetic response either as one beat or as a sequence of beats. This is called synchronous response and was found when the target frequency was below 3 Hz and the target speeds below 20--30 degrees/sec, depending on the actual frequency. At higher target frequencies and target speeds, the eyes were unable to take up every target, resulting in uneven responses (hyposynchronous response). Very low target frequencies and target speeds were likewise unsuitable due to drifting of the eyes from one target to another. A target frequency and a target speed close to the upper limit for synchronous response is advocated in clinical tests of OKN. 2 Hz and 20 degrees/sec is proposed as a suitable combination of frequency and target speed.

Adolescent↗