Biomedical subjects

E Pierzchała

Publications and source records attributed to E Pierzchała.

4 recordsLinked to original sources

PubMed2001

[The role of cell-mediated immune response in pathogenesis of alopecia areata].

Recent studies have suggested that cell-mediated immune response play a critical role in the pathogenesis of alopecia areata (AA). Eighteen patients with AA were included in the study. Fifteen healthy subjects served as controls. Serum levels of sTNF alpha RI and sIL-2R were measured using enzyme-linked immunosorbent assay technique. The serum levels of sTNF alpha RI were significantly elevated in patients with AA in comparison with control group. The serum levels of sIL-2R were higher in AA patients than in healthy subjects but not significantly. These results indicate, that immune mechanisms in AA are characterized by activation of T cells and other cells, possibly keratinocytes.

Adult↗

PubMed2000

[Anetoderma--a clinical and therapeutic problem].

Current views on etiopathogenesis of anetoderma have been presented on the grounds of literature data. Disorders of elastin metabolism are distinctive for the disease causing elastin fibres becoming disintegrated and atrophied. Apart from mechanism of anetoderma plaques evolution clinical observation and full diagnostication of systemic collagenosis seems to be important. Despite of numerous therapeutic trials it appears that medication of anetoderma lesions is inefficacious.

Atrophy↗

PubMed1999

[Detection of high-risk group with irritant hand dermatitis].

Patients with atopy and especially these with atopic skin diseases, hand eczema and dishidrosis have been identified as a high-risk group developing irritant hand dermatitis. To improve prevention pre-occupational examinations (screening tests) in youth have been proposed. Dermatological examinations, questionnaires and some bioengineering techniques are usually suggested. The necessity of application of ASD score has been confirmed. Because of the high irritant hand eczema morbility and socio-economic consequences detection of high-risk group plays a special role. It is possible by means of: 1. Special questionnaires 2. Dermatological examinations, education, observation 3. Conception and realization of skin--safe working conditions.

Dermatitis, Contact↗

PubMed1999

[Monilethrix--rare syndrome of structural hair abnormalities].

Monilethrix is a rare structural disorder of hair. Characteristic abnormalities in the form of alternating thinning and fusiform thickening are observed in most of hair shafts that we call beaded hair. Macroscopic estimation shows lustreless, dry, rough, fragile hair. Trichological examination usually reveals a considerable percentage of anagenic hair. According to our own experiences and literature data systemic therapy (vitamins) and topical treatment (desquamative ointments) are not effective sufficiently. Spontaneous regression of symptoms often appears with time. Five cases of familial occurrence of monilethrix have been presented.

Child↗