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Biomedical subjects

E Pilger

Publications and source records attributed to E Pilger.

At least 91 records · Page 5Linked to original sources
PubMed1990

White fingers after excessive motorcycle driving: a case report.

An 18-year-old male presented with Raynaud's phenomenon which was found to be caused by occlusion of the proper palmar digital arteries on the right hand and obstruction of the superficial palmar arterial arch on the left hand. These lesions in the arteries of both hands resemble those found in patients with vibration-induced white fingers such as in mine or foundry workers. The only likely cause for the pathological vascular findings in our patient was an exposure to vibration due to excessive off-street motorcycle driving. Therapy with intraarterial prostaglandins resolved the ischemic syndrome but it promptly recurred when the patient resumed motor cycle driving. Therefore, we suggest that excessive cross country motor cycle driving may cause vibration-induced white fingers.

Adolescent↗
PubMed1989

The influence of elevated Mg2+ concentrations on cardiac electrophysiologic parameters.

This study was performed to evaluate the direct effects of magnesium ions on cardiac conduction velocities and on refractoriness using a modified Langendorff perfusion system and a special ECG recording and stimulation technique. An increase of the MG2+ concentration to 2.3 mM had no detectable effects. Higher concentrations of up to 4.6 mM decreased the spontaneous sinus rate and the conduction velocity through the AV node and the His bundle in a concentration-dependent manner. During stimulation with premature beats, in the presence of 4.6 mM of Mg2+, the effective and relative refractory periods (ERP, RRP) of sinoatrial, AV nodal, and His bundle conduction and the ERP of the ventricular myocardium were significantly prolonged, whereas the ERP of the atrial myocardium remained unaffected. The refractoriness of sinoatrial, AV nodal, and His bundle conduction, and of the ventricular myocardium, were also prolonged during pacing with a stepwise increased pacing rate. These observations suggest a marked rate-dependent inhibitory effect of magnesium on the refractoriness of the His-bundle conduction and of the ventricular myocardium, which might be an important factor in the antiarrhythmic effectiveness of magnesium in ventricular tachyarrhythmias.

Animals↗
PubMed1989

Contact probes for intravascular laser recanalization. Experimental evaluation.

Experimental laser ablation of atheromatous plaques was performed with a bare quartz glass fiber, a metal probe, and a sapphire probe. The tissue response after irradiation with increasing energies was evaluated by means of light and scanning electron microscopy. Laser emission through the bare fiber caused a narrow, deep crater with an irregular surface surrounded by a zone of thermal necrosis. After tissue ablation with the metal probe, a disproportion between the small tissue defect and the large zone of thermal necrosis was observed. The largest tissue defect was vaporized by the sapphire contact probe. A small zone of thermal necrosis surrounded the laser crater.

Arteries↗
PubMed1989

[Current state and perspectives of laser use in vascular surgery].

We report on a project to determine the feasibility of treating carotid artery stenosis with the argon laser (1985) and the clinical results of recanalising peripheral arteries. Training for the above-mentioned project showed that sapphire-tipped Nd:YAG laser optical fibers are the proper instruments for recanalisation. New attempts with new catheter material should make the recanalisation of the carotid artery possible in the future.

Adult↗
PubMed1988

[Change in impulse formation and impulse transmission of the heart in relation to high magnesium concentration].

The effects of magnesium ions on the cardiac conduction velocity and on the refractory periods of the single parts of Langendorff perfused guinea pig hearts were studied using a high amplifying ECG recording and a special stimulation technique. Concentrations of 2.3 mM or 3.45 mM Mg++ had only little inhibitory effects on the cardiac conduction velocity and on the sinus node activity. The elevation of the magnesium ion concentration to 4.6 mM caused a reduction of the spontaneous sinus rate and a prolongation of the AV nodal and His bundle conduction time. During stimulation with stepwise increasing pacing rate, a marked prolongation of the refractoriness of the His bundle conduction and of the ventricular myocardium was detectable. This frequency dependent inhibitory influence on the His bundle and the ventricular myocardium could be an explanation for the antiarrhythmic efficacy of magnesium ions during ventricular tachyarrhythmias.

Animals↗
PubMed1988

[Prostaglandin E1 in decreased arterial perfusion].

Prostaglandin E 1 has been used for the past 15 years in decreased peripheral arterial perfusion with differing degrees of success. The exact mechanism of action has not been clarified so far. Vasodilatation, increased fibrinolytic activity and an improved cellular metabolism were observed in response to PGE 1 in animal experiments both in vivo and in vitro. In the clinical studies performed so far PGE 1 has been used in cases of decreased peripheral arterial perfusion after functional, inflammatory, degenerative or diabetic arteriopathy (stages IIb-IV). Reduction or alleviation of ischaemic rest pain, as well as a faster healing of tissue necrosis was reported after intaarterial administration, especially in non-controlled, but also in controlled studies. Intravenous administration of PGE 1 had a positive influence on clinical symptoms in non-placebo-randomized patients; in the controlled studies, however, the results were not significant. The greatest therapeutic success can be achieved using intermittent intraarterial administration in decreased peripheral arterial perfusion due to functional or inflammatory arteriopathies.

Alprostadil↗
PubMed1988

Laser angioplasty with a contact probe for the treatment of peripheral vascular disease.

Percutaneous transluminal laser angioplasty was carried out for the dilatation of 30 completely occluded peripheral arterial segments and three subtotal stenoses. A neodymium-YAG laser and an optical fibre delivery system with a sapphire tip were used. All three arterial stenoses and 26 of the 30 occluded arterial segments were successfully dilated. In 20 patients additional dilatation was carried out with a balloon catheter. Laser angioplasty failed to recanalise four occlusions, and vessel leakage without clinical consequences occurred in one patient. Reocclusion occurred within 48 h in two patients and after five months in one patient during a follow up period of at least six months. It is concluded that percutaneous transluminal laser angioplasty using direct contact with a sapphire tip is highly effective (89% success rate) in reopening peripheral vascular occlusions. The procedure is safe, and reocclusion of vessels is rare during the six month follow up period.

Adult↗