Biomedical subjects
Publications and source records attributed to E Poppe.
In 18 patients with retinal vein occlusion the authors used Pentoxifylline in droplet infusion for an increased deformation of erythrocytes. In all the patients they observed a substantial improvement of all physiological parameters of the visual system.
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The authors evaluated the efficacy of Quinax in 4 groups of patients with cataract. An observation of--on the average--5 years duration showed that systematic application of the drug prevents the development of the early senile cataract and distinctly slows down the progress of the disease in the group of patients without the risk factors. Non systematic application of the compound also slows down the progress of the condition in the group of early cataract. The drug was ineffective in patients with an advanced diabetic cataract.
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Cervical lymph node metastases developed in 45% of patients with T1N0 squamous cell carcinomas of the oral tongue in spite of local control of the primary lesions in 79%. The control rate for the neck of those who converted from a negative to a positive neck (N0-N+) was 33%. Neck node metastases developed in 49% of patients with T2N0 tumors. The control rate of the primary tumor was 32%, and the control rate of the neck of those whose neck nodes converted (N0-N+) was 16%. Neck node metastases developed in 42% of patients with T3N0 tumors. The control rate of the primary tumors was 33%, and the control rate of the neck of those who converted (N0-N+) was 7%. The development of neck node metastases in patients after treatment of the primary tongue carcinoma is of grave prognostic significance. The use of elective treatment to the neck at initial treatment can prevent metastases in the neck from developing if the primary tumor is under control.
Results of therapy in 300 patients with squamous-cell carcinoma of the anterior two thirds of the tongue are presented in terms of control of the primary tumor (local) and metastases to the lymph nodes of the neck (regional). Correlation between clinical stage and control was good, with the best results being obtained in stage T1N0 (84% control of tongue, 69% control of neck) and the poorest results in TX N2N3 (9% and 11%, respectively). Different methods of treatment were analyzed separately for various stages of disease and compared with results from other institutions. Possible methods of improving treatment are discussed.
The records of 503 patients with carcinoma of the tongue diagnosed between 1958 and 1972 were reviewed. The preponderance of tongue carcinoma among men was confirmed both in The Norwegian Radium Hospital (NRH) and the University of Wisconsin Hospitals (UW), but it was relatively more frequent among women in NRH and in UW than in southern Europe. More women had on presentation less advanced tumors at NRH than at UW. The incidence of tongue carcinoma in Norway increased steadily with age for both sexes. The sex ratio did not change in Norway such as in England, Canada and the United States. Tumor of the posterior one-third of the tongue was relatively infrequent in women both in NRH and UW, in agreement with reports from other countries. The length of survival was analysed and no significant sex difference was demonstrated. The younger patients had less advanced tumors and a better prognosis.
The local control rates in patients with squamous cell carcinoma of the tongue, treated between 1958 and 1972, were determined by retrospective analysis of the records of 339 patients at the Norwegian Radium Hospital and of 164 patients at the University of Wisconsin Hospitals. The correlation between the clinical stage and the local control rate was good in Norway, less striking in Wisconsin. As the tumor grew in size it generally became increasingly difficult to control. Irradiation and surgery appeared relatively satisfactory in patients with tumors in early stages, but were often inadequate in the advanced tumors. The differences observed between Norway and Wisconsin were statistically significant only for the tumors of the base of the tongue and T2N0, T3N0 and TxN1 tumors of the anterior two-thirds of the tongue.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.