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Biomedical subjects

E Porta

Publications and source records attributed to E Porta.

At least 19 recordsLinked to original sources

Natural history and postsurgical outcome of syringomyelia.

The surgical treatment of syringomyelia is still debatable and the result are often poor. Several surgical procedures, based on various proposed etiopathologies, have been developed but in many cases have proved completely ineffective. We have evaluated the follow-up of 69 syringomyelic patients, some operated on, some not, in the search for clues to the management of the disease. For this purpose we devised a rating system, which we describe. 31 patients underwent surgery while 38 received no treatment. We found that half of the patients deteriorated, whether they were operated on or not; only 1 in 5 improved and the rest remained stable. For surgical treatment to be successful, the disease must be in rapid evolution but without definite paraparesis.

Adult

Total or partial percutaneous renal ablation in the treatment of renovascular hypertension: radiological and clinical aspects.

In 15 patients with renovascular hypertension, considered unsuitable for angioplasty or surgery, percutaneous renal ablation was performed by injection of ethanol into the renal vasculature. Partial or complete renal ablation was confirmed by follow-up intravenous pyelography or arteriography. Patients were followed-up for a mean of 24.8 months after therapy and blood pressure was improved in all patients with five being cured. This study shows that percutaneous renal ablation is a useful and successful method of therapy for renal hypertension, and that it should be considered in patients unsuitable for surgery or angioplasty.

Adolescent

[Use of magnetic resonance in the diagnosis of congenital and acquired cardiopathies. Preliminary note].

The authors describe their personal experience using Magnetic Resonance Imaging (MRI) in the evaluation of cardio-vascular diseases. MRI made it possible to obtain multiplanar anatomical images of the cardio-vascular system without X-rays and conventional contrast medium. MRI supplied with indirect flow evaluation, too. MRI was particularly useful in the assessment of congenital heart diseases, since it shows the heart chambers and the great vessels at the same time and in the different phases of cardiac revolution. MRI was also useful in the evaluation of many acquired heart diseases, such as myocardium diseases, valve diseases, myocardial ischemias, pericardium diseases. Moreover, MRI correctly showed aortic aneurysms. In all the 55 patients examined, it was possible to obtain a good definition of the cardiac structures, especially when "cardiac gating" was employed. In the 3 ventricular and in the 5 atrial defects, the dimensions of the defect and the dilatation of the involved cardiac chambers were precisely assessed. In the 6 aortic coarctations, MRI evaluated the level and the grade of the stenosis, with consequent definition of the anatomic type. Moreover, collateral circulation and dilatation before and/or after the stenosis were evident. In all the 7 complex cardiopathies examined (3 Fallot tetralogies, 1 Fallot pentalogy, 1 aortic cervical arch, and 2 Ebstein diseases) MRI demonstrated each single anomaly of the malformations, at both cardiac and vascular levels. In 2 patients with atrial fibrillation, MRI visualized endoatrial thrombi. In the 7 patients with previous myocardial infarction, the site of ischemia was depicted as a thinning of the wall, while the remaining myocardium appeared hypertrophic. MRI correctly demonstrated all thoracic aorta aneurysms, even in a case where both CT and angiography were negative, due to the aneurysm being thrombosed. Mural thrombi were evident with both MRI and CT, but not always visible with angiography. In the 5 dissected aneurysms, MRI--like CT--assessed the origin of the dissection, and the dimensions of the true and false lumen; moreover, it indirectly evaluated the slow and turbulent blood flow within the true lumen, and the presence of thrombi in the false lumen.

Adolescent

Silicone biliary stents.

Large silicone stents (9-28 French) were placed in the biliary tree of 173 patients over a 3-year period. Their use markedly reduced the incidence of catheter occlusion and sepsis. Only three cases of cholangitis and one case each of excessive bleeding and pleural effusion occurred. No skin irritation or pancreatitis occurred. The large bore of the catheter and the use of biocompatible material improved the safety and efficacy of biliary drainage.

Biliary Tract

Herpes zoster myelitis: nervous system complications.

Transverse myelitis after a zoster viral infection is an exceptional occurrence. In this case we documented an antibody activity against varicella zoster (V-Z) in the cerebrospinal fluid in association with Coxsackie A enterovirus. The clinical course was atypical because of a second episode of myelitis 2 years after the first episode of neurologic viral complications. The positive outcome of therapy with Acyclovir is noteworthy. This case was retrieved in a review of neurologic complications observed in the last few years in patient affected by zoster in our hospital.

Acyclovir

Calcium entry blocker: treatment in acute pain in cluster headache patients.

15 chronic cluster headache patients in whom pain was induced by nitroglycerin received acute intravenous treatment with a calcium entry blocker. At the time of peak pain we noted a sudden decrease after the Verapamil injection. The mechanism by which the calcium entry blocker afforded relief is unlikely to have been vasodilatation in patients whose blood vessels had just been dilated by nitroglycerin. A more probable mechanism is blockade of the release of the pain-inducing neurotransmitters. The vasodilatation phase is not a primary factor in the onset of pain.

Blood Pressure

Embolization of glomus tumors of the carotid: temporary or definitive?

The authors describe the use of preoperative embolization of glomus tumors in 7 patients. In two cases a nonresorbable substance (IBCA) was used for the embolization, and no subsequent operation was needed. They therefore suggest that embolization could be a definitive treatment and an alternative to surgery.

Adult

Two basic properties of space representation in the brain: evidence from unilateral neglect.

It is argued, on the grounds of earlier findings, that the neural substrate of egocentric space representation has analogue (non-symbolic) topo-topical properties. It is then argued from fresh evidence that space representation appears to be anchored to the sagittal midplane of the trunk and to the line of sight. A tentative reduction of the suggested properties of space representation to the neuro-physiological level is briefly outlined.

Brain

[Radiology in chronic constipation in childhood].

One hundred thirteen children referred for chronic constipation were examined by means of diagnostic work-up including anal inspection, rectal exploration, weekly bowel frequency evaluation, measurement of total and segmental intestinal transit times (TITT, SITT), contrast enema, anorectal manometry (ARM), suction rectal biopsy for histochemistry. Final diagnosis were: chronic functional "simple" constipation in 53 children; chronic functional constipation and soiling in 32; Hirschsprung's disease in 18. In 10 children, initially referred for constipation, TITT was in the normal range so they underwent no further examination. Conclusions are that bowel frequency identifies a real gastrointestinal problem, but definite diagnosis of constipation is relied on TITT. In the assessment of chronic constipation nature, ARM is more sensitive than radiology. Suction rectal biopsy is reliable in detection of aganglionosis: its accuracy can be improved by histochemical or biochemical determination of Acetylcholinoesterase.

Acetylcholinesterase