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Biomedical subjects

E Pozzi

Publications and source records attributed to E Pozzi.

At least 73 records · Page 4Linked to original sources
PubMed1985

Endocrine-paracrine cells in prostatic carcinoma and clinical course of the disease.

The occurrence of endocrine-paracrine (argyrophil and argentaffin) cells in normal and hyperplastic human epithelia has long been recognized. 40 consecutive prostatic carcinomas were studied histochemically and ultrastructurally. The authors consider only clinically evaluable cases and discuss the clinical significance of the presence of endocrine-paracrine cells on the basis of their personal experience.

Adenocarcinoma↗
PubMed1985

Pharmacokinetic studies on antituberculosis regimens in humans. I. Absorption and metabolism of the compounds used in the initial intensive phase of the short-course regimens: single administration study.

The absorption and metabolism of streptomycin, isoniazid, rifampicin, and pyrazinamide were evaluated after administration of each drug alone and in combination. In the combination sessions, isoniazid, rifampicin, and pyrazinamide were administered orally, either individually or in a single fixed-ratio triple preparation. The results have shown that the pattern of absorption and metabolism (acetyl-isoniazid, desacetyl-rifampicin, and pyrazinoic acid) found after administration of each drug alone did not differ from that found after administration of the drugs in free and fixed combination. The 3 orally administered drugs given in a fixed combination resulted in a reduction of the order of 50% of the total number of tablets to be ingested.

Absorption↗
PubMed1984

Interstitial pneumopathy and low-dosage amiodarone.

In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed. In the absence of other causes, we suspected an adverse reaction to amiodarone, not least because of the similarity with histologic findings of cases previously reported. Drug withdrawal and cortisone administration led to resolution of the disease.

Amiodarone↗
PubMed1978

On the pathogenesis of bleomycin lung toxicity.

Bleomycin is potentially capable of inducing a diffuse interstitial fibrosis of the lung, the pathogenesis of which has not yet been elucidated. The authors have demonstrated that after 48 hr of acute treatment, morphological and functional modifications could be seen in type II pneumocytes, which are responsible for surfactant production. This might be the earliest stage of pulmonary damage.

Animals↗
PubMed1977

Psychotropic drugs: influence on respiratory function.

The authors investigated, in 22 normal subjects and 22 bronchopneumopathic patients, the action of two anxiolytic drugs on ventilatory function and on the associated respiratory function. The analyses carried out before drug administration and 1, 2, 6 hours later showed that while a drug did not cause any important variation in the ventilatory parameters and O2 uptake, both in healthy subjects and in patients, the second one clearly reduced the ventilatory efficacy and O2 uptake. This behavior was quite evident 1 and 2 hours after the assumption of the drug while after 6 hours the parameters returned to the initial values. The influence of the circadian rhythm after 6 hours was more evident in both groups after the assumption of the second anxyolitic drug than with the first. Furthermore, evaluation drawn up among the healthy subjects, during simulated driving tests, demonstrated that the second anxyolytic drug provoked a standard depression unevenly distributed like that obtained after the ingestion of a fixed dose of an alcoholic drink.

Bronchopneumonia↗
PubMedDate not supplied

Detection of multidrug resistance associated P-170 glycoprotein in previously untreated non small cell lung cancer.

Samples of Non Small Cell Lung Cancer (NSCLC) and normal bronchial tissue obtained in patients submitted to radical surgery and without previous exposure to cytotoxic drugs were investigated for the expression of P-170 glycoprotein using C-219 monoclonal antibody and an immunohistochemistry technique. In normal bronchial tissue the immunostaining was confined to the lumenal surface of the epithelium. Fifteen out of 86 NSCLC had more than 1/4 of examined cells positive for P-170 glycoprotein, but the heterogeneity of the expression ranged from rare scattered cells to a positive pattern for nearly all cells considered, without any relationship with pathologic and clinical prognostic variables.

ATP Binding Cassette Transporter, Subfamily B, Mem↗