PubMed Health⌕ Search

Biomedical subjects

E Proctor

Publications and source records attributed to E Proctor.

At least 55 records · Page 3Linked to original sources
PubMed1984

Temporomandibular joint internal derangements: CT diagnosis.

Two hundred patients with suspected displaced temporomandibular joint meniscus were studied with computed tomography. In 75 cases confirmation of the CT diagnosis was subsequently obtained via surgery or arthrography; correlation was found in 73 cases (97%), with one false-negative and one false-positive examination. When meniscus displacement was graded as "mild," "moderate," or "severe," those cases diagnosed as moderate or severe were more likely to require surgery. The technique and interpretation of this technique is described; in most cases CT can replace arthrography in diagnosing displaced temporomandibular joint menisci.

Adolescent↗
PubMed1984

Standardized micronodular cirrhosis in the rat.

The production of experimental cirrhosis in the rat, most commonly by multiple doses of carbon tetrachloride (CCl4), is a difficult process with a low yield of 'cirrhosis' of widely varied histology. This is due to an unpredictable variation in the response of the rat liver to CCl4. Using a method of monitoring the body weight change of the rat in response to intragastric CCl4 has produced a high yield (76%) of cirrhosis with 8-10 doses of CCl4. This improved control over liver damage has now made it possible to produce a 'standardized' type of decompensated micronodular cirrhosis. A simple non-invasive method of determining when this point has been reached, using a visual grading of ascites during light halothane/oxygen anaesthesia, is described.

Animals↗
PubMed1983

Safety and efficacy of diphetarsone in the treatment of amoebiasis, non-pathogenic amoebiasis and trichuriasis.

Eighty-nine patients infected with Entamoeba histolytica, non-pathogenic amoebae or Trichuris trichiura were studied prospectively to determine the safety and efficacy of diphetarsone therapy. An additional 75 patients were studied retrospectively to assess further the efficacy of diphetarsone in the treatment of E. histolytica cyst passers. Side effects were noted in 9% and included gastrointestinal upset, lightheadedness and headache. Transient liver function abnormalities were recorded in 5.6%. diphetarsone was completely effective in the treatment of Dientamoeba fragilis, Entamoeba hartmanni, Iodamoeba buetschlii and Trichuris trichiura. 99% of the patients with E. histolytica, 97% of those with E. coli and 98% of those with Endolimax nana were cured.

Adult↗
PubMed1983

Controlled induction of cirrhosis in the rat.

The production of experimental cirrhosis in the rat, most commonly by multiple doses of carbon tetrachloride (CCl4), is a difficult process with a low yield of "cirrhosis" of widely varied histology. This is due to an unpredictable variation in the response of the rat liver to CCl4, and the lack of a reliable method of monitoring the rapidly changing liver damage with each dose. A simple non-invasive method is described in which the daily body weight change of the rat in response to weekly intragastric doses of CCl4 has been shown empirically to sufficiently reflect the state of the liver as to enable each dose of CCl4 to be calibrated by the weight change of the previous dose. The death rate is markedly reduced and a critical level of liver damage can be maintained. This improved control over liver damage has made it possible to produce a high yield (72%) of a standardized decompensated micronodular cirrhosis with 8-10 doses of CCl4. Under these weight-calibrated conditions this point is determined non-invasively by using a visual grading of a critical level of ascites estimated during light halothane/oxygen anaesthesia to relax the abdominal musculature.

Aging↗
PubMed1982

High yield micronodular cirrhosis in the rat.

Although studied for most of this century there is still no reliable model of severe decompensated micronodular cirrhosis that can be predictably produced in reasonable quantity. The current most successful model, inhalation of carbon tetrachloride vapor in the phenobarbitone-induced rat, has a low yield of severe cirrhosis and a high death rate because there is no way to determine both the variation in response to carbon tetrachloride and the maintenance of a constant critical level of liver damage. A new approach to this old problem is described in which both variation and level of critical damage are monitored by the daily weight change of the rat in response to intragastric carbon tetrachloride given during light halothane/oxygen anesthesia; the response each time being used to calibrate the subsequent dose of carbon tetrachloride to fit the individual rat. The method is effective in producing cirrhosis with ascites in about 75% of rats after 8-10 doses of carbon tetrachloride.

Animals↗
PubMed1981

Phenobarbitone-induced enlargement of the liver in the rat: its relationship to carbon tetrachloride-induced cirrhosis.

The yield of severe cirrhosis of the liver (defined as a shrunken finely nodular liver with micronodular histology, ascites greater than 30 ml, plasma albumin less than 2.2 g/dl, splenomegaly 2-3 times normal, and testicular atrophy approximately half normal weight) after 12 doses of carbon tetrachloride given intragastrically in the phenobarbitone-primed rat was increased from 25% to 56% by giving the initial "calibrating" dose of carbon tetrachloride at the peak of the phenobarbitone-induced enlargement of the liver. At this point it was assumed that the cytochrome P450/CCl4 toxic state was both maximal and stable. The optimal rat size to begin phenobarbitone was determined as 100 g, and this size as a group had a mean maximum relative liver weight increase 47% greater than normal rats of the same body weight. The optimal time for the initial dose of carbon tetrachloride was after 14 days on phenobarbitone.

Animals↗
PubMed1980

Stented xenograft valve insertion.

A simple holder and the associated technique for temporarily converting the stented xenograft type of valve into a Starr-Edwards configuration are described. With this technique, the struts are not caught by the sutures during insertion.

Bioprosthesis↗
PubMed1979

Antibody responses to influenza immunization of children with acute lymphoblastic leukemia.

Antibody responses of two doses of a bivalent influenza vaccine containing A/Victoria/75 (A/Vic/75) and A/New Jersey/76 (A/NJ/76) viral antigens were studied in 22 children receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL), 16 children no longer receiving therapy for ALL, and 50 sibling controls. Before immunization, the three groups showed no difference in titer of antibody to either antigen. After the first immunization, children off therapy showed significantly higher titers to A/NJ/76 than did either sibling controls of children receiving therapy (P less than 0.01). After the second immunization, children off therapy showed significantly higher antibody titers to both antigens than did children receiving therapy or controls (P less than 0.01 for both A/NJ/76 and A/Vic/75). Antibody titers of children receiving therapy were not significantly different from those of controls. A year later, there were no significant differences in antibody titers among the groups. Thus, children with ALL who are receiving chemotherapy respond normally to two doses of influenza vaccine, whereas children off therapy manifest abnormally high titers of antibody to both influenza virus antigens.

Antibodies, Viral↗