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Biomedical subjects

E R Abbatiello

Publications and source records attributed to E R Abbatiello.

8 recordsLinked to original sources
PubMed1979

Effects on the offspring of chronic low exposure carbon monoxide during mice pregnancy.

This research is primarily concerned with the effects of chronic low doses of carbon monoxide on fetal development. Carbon monoxide was administered daily by inhalation to female Swiss Webster mice from the beginning of gestation until term. Daily weights were recorded and carbon monoxide blood levels determined every 4 days. The number of offspring in each litter was recorded. At weaning, two males and two females from each litter were randomly picked for maze running studies. When the mice were 6 weeks old, they were tested daily, ten trials per day, in the maze until learning had occurred. The number of days required to learn the maze and the number of incorrect trials were recorded. While there was no significant increase in the number of days needed to learn the maze, there was a significant increase in the number of errors made by the experimental group during this time. This indicated that an increased effort was needed to learn the maze.

Animals↗
PubMed1976

The effect of prostaglandins F1 alpha and F2 alpha on spermatogenesis.

The effect of the prostaglandins F1 alpha and F2 alpha on spermatogenesis in the mature male mouse has been studied. Administration of prostaglandins F1 alpha and F2 alpha subcutaneously at a dose of 3 mg/kg once a day for 15 days produced a pronounced decrease in spermatogenesis primarily during the meiotic phase as reflected by a significant decrease in stage 7 spermatids as compared to controls. PGF2 alpha produced a stronger suppression than did PGF1 alpha. Accessory reproductive gland weights also appeared to be reduced by the prostaglandins, although not consistently. Histopathological examination revealed increased numbers of exfoliated immature germinal cells in the seminiferous tubules and epididymi of prostaglandin treated animals. When the effect of PGF1 alpha and PGF2 alpha were compared to those of PGE1 and PGE2 it was found that PGE2 produced the strongest suppression, with PGF2 alpha, PGE1 and PGF1 following in decreasing order respectively.

Animals↗
PubMed1975

Effects of cyproterone acetate on uterine motility in rats.

The effect of cyproterone acetate, an antiandrogen, on uterine contractility when the compound is administered to rats during midpregnancy was investigated. Pregnant Wistar rats were given cyproterone acetate subcutaneously on Days 8-11 of gestation. The results indicate that cyproterone acetate, either directly or indirectly, inhibits uterine contractility, an effect that may explain the prolongation of the gestational period observed in all treated animals.

Animals↗
PubMed1975

The effect of prostaglandins and prostaglandin inhibitors on spermatogenesis.

The effect of the prostaglandin inhibitors, aspirin and indomethacin and of prostaglandins PGE1 and PGE2 on spermatogenesis in the mature male mouse has been studied. Aspirin at 100 mg/kg and at 200 mg/kg, and indomethacin at 1.0 mg/kg given orally twice a day for fifteen days produced a marked increase in spermatogenesis. The number of step 7 spermatids increased significantly over controls at about the same rate in all three groups. No significant changes in seminal vesicle weight or testicular weight was noted, although testicular weight did show an increase. Administration of prostaglandins E1 and E2 subcutaneously in doses of either 2 mg/kg or 3 mg/kg once a day for fifteen days produced a marked decrease in spermatogenesis. Step 7 spermatids decreased significantly at both dosage levels of PGE2 and at the higher dosage level of PGE1. Spermatocyte showed a significant decrease at the higher dose of PGE2. Testicular weight showed a significant decrease at the higher dose of PGE2. Seminal vesicle weight showed a significant decrease at the lower dose of PGE1 and at the higher dose of PGE2. Epididymal weight decreased at the higher dose of PGE2. Increased numbers of exfoliated immature germ cells and mature spermatozoa were observed in the epididymus of both the PGE1 and PGE2 treated animals.

Animals↗