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Biomedical subjects

E R Christensen

Publications and source records attributed to E R Christensen.

11 recordsLinked to original sources
PubMed1988

Primary epiphyseal osteomyelitis in children. Report of three cases and review of the literature.

In the literature 21 children have been reported with haematogenous osteomyelitis involving only the epiphyses of long bones; in 20 the epiphyses of the knee were involved and the radiographs showed a lytic lesion. Most patients gave a history of pain, limp or refusal to walk for weeks or months without general illness. The erythrocyte sedimentation rate and white cell count were of little diagnostic value, but a bone scan was usually positive. All the patients were cured by antibiotics alone or in combination with curettage.

Child, Preschool↗
PubMed1985

A general noninteractive multiple toxicity model including probit, logit, and Weibull transformations.

A multiple toxicity model for the quantal response of organisms is constructed based on an existing bivariate theory. The main assumption is that the tolerances follow a multivariate normal distribution function. However, any monotone tolerance distribution can be applied by mapping the integration region in the n-dimensional space of transforms on the n-dimensional space of normal equivalent deviates. General requirements to noninteractive bivariate tolerance distributions are discussed, and it is shown that bivariate logit and Weibull distributions, constructed according to the mapping procedure, meet these criteria. The univariate Weibull dose-response model is given a novel interpretation in terms of reactions between toxicant molecules and a hypothetical key receptor of the organism. The application of the multiple toxicity model is demonstrated using literature data for the action of gamma-benzene hexachloride and pyrethrins on flour beetles (Tribolium castaneum). Nonnormal tolerance distributions are needed when the mortality data include extreme response probabilities.

Analysis of Variance↗
PubMed1975

Behavior therapy versus "will power" in the management of obesity.

In a study of the management of obesity 43 patients were randomly assigned to behavior therapy, will power, and no-treatment control groups. The behavioral treatment involved contingency contracting, stimulus control, self-monitoring, energy expenditure, and group reinforcement procedures over an 18-week period. The will power patients were told to do the same thing as the behavior therapy patients; however, instead of having formal contingencies and meeting regularly, they were told to apply "will power" on their own, as this was the most important aspect of losing weight. The third group was a standard no-treatment control group. Analyses of covariance indicated that (a) the behavior therapy group lost significantly more weight than the will power (p less than .05) and no-treatment control (p less than .01) groups, and (b) the will power and no-treatment control groups did not differ significantly from each other. An 18-week maintenance follow-up of the behavior therapy group indicated that there was no significant weight gain from the end of treatment to follow-up. Also, an analysis of time spent per patient suggested that the behavioral treatment employed in this study was more efficient than previous treatments.

Adolescent↗