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Biomedical subjects

E R Lopes

Publications and source records attributed to E R Lopes.

At least 37 records · Page 2Linked to original sources

[Internship in Public Health at the Faculdade de Medicina de Botucatu].

An experiment in the teaching of public health for interns in the sixth year of medical training was launched in 1978 on the basis of the clinical practice of health services in Botucatu and neighboring municipalities. The course was designed to promote the practice of primary medical care, contacts with the different health professionals, analysis of the relations between health and the social structure, and an understanding of the organization of medical care in Brazil through discussions of day-to-day activities in health services, and of the role of medicine and medical care in the present capitalistic production structure of Brazil. The paper reports on the teaching experiment in 1978 and 1979, when the supervised training was taken by 85 and 95 interns, respectively, in groups of seven or eight for periods of 18 working days at the Botucatu Health Center-School (CSE) and the Anhembi and Itatinga Health Services. A comparison of the answers to tests given before and after the training and the opinions recorded by the students on the activities carried on show an improvement in their perceptions of team-work and of health education in the role of medicine and medical care in society. Most of the students expressed open approval of the training as a whole.

Brazil↗

Post-mortem diagnosis of chronic Chagas's disease comparative evaluation of three serological tests on pericardial fluid.

In an attempt to improve the post-mortem diagnosis of Chagas's disease the authors performed haemagglutination tests (HAT), fluorescent Trypanosoma cruzi antibody tests (FAT), and complement fixation tests (CFT) on the pericardial fluid obtained at autopsy of 50 individuals with Chagas's heart disease, and 93 patients in whom this disease was not thought to be present. The results demonstrate that all three tests are efficient for the post-mortem diagnosis of Chagas's disease but suggest that their combined use would detect more cases than would one isolated reaction only.

Antibodies↗

Total and specific anti-Trypanosoma cruzi immunoglobulin E in pericardial fluid samples from patients with chronic Chagas disease.

Levels of total and specific anti-Trypanosoma cruzi immunoglobulin E (IgE) were determined by immunoenzymatic assay among 101 samples of pericardial fluid from patients who had died in one trypanosomiasis endemic area in central Brazil. These samples were divided into 6 groups. Group I, 17 samples from patients with the cardiac form of Chagas disease; group II, 11 samples from patients with the digestive form of Chagas disease, presenting megaoesophagus and/or megacolon; group III, 41 samples from patients with the indeterminate form of Chagas disease; group IV, 4 samples from patients with both cardiac and digestive forms of Chagas disease; group V, 5 samples from patients who suddenly died and were seropositive for T. cruzi antibodies; group VI, 23 samples, used as a control group, which came from patients seronegative for T. cruzi antibodies. Significantly high levels of total IgE were observed in groups I, II, III, IV and V when compared with group VI (mean concentrations 708-1157 iu/mL compared with 394 iu/mL). In groups I-V, 32 samples (41%) had specific anti-T. cruzi IgE antibodies. The individual percentage positivity rates in these groups were 64.7% (group I), 45.4% (group II), 34.1% (group III), nil (group IV), and 40.0% (group V). A significant correlation between total IgE and specific anti-T. cruzi IgE was observed only in the samples from patients with the cardiac form of Chagas disease (group I).

Animals↗