1. The effects of tricyclic antidepressants were studied on the isolated perfused guinea-pig heart simultaneously recording myocardial contractile force and cardiac electrogram. 2. Tricyclic antidepressants in a concentration 4 X 10(-5) mol/1 decreased cardiac contractile force and increased cardiac conduction time. 3. Doxepin had significantly greater negative inotropic effect than nortriptyline, protriptyline, desipramine, amitriptyline and imipramine (P less than 0.01). 4. There was no significant difference in the increase in P-R interval (P less than 0.5) and QRS width (P greater than 0.95) between the tricyclic antidepressants. 5. The isolated perfused guinea-pig heart can be used as a toxicological model for testing and treating cardiac arrhythmias induced by tricyclic antidepressants.

Animals↗

PubMedDate not supplied

Vagotomy for peptic ulceration.

Explore the source record for details and available documents.

Animals↗

PubMedDate not supplied

Chemical radiculitis. A clinical, physiological and immunological study.

Chemical radiculitis is an inflammatory condition of the nerve root due to the rupture of the annulus fibrosus and dissemination of disk fluid along the nerve root sheath. The inflammatory component of disk fluid is glycoprotein. The inflammation is a reaction to repeated injuries of the spinal column, as for example, in occupational lifting of heavy loads. Rupture of the annulus fibrosus and liberation of disk fluid into the tissues also evokes circulating antibody response and auto immune reaction. A high titer to glycoprotein at 3 weeks after an acute attack of back pain is evidence of the presence of a significant disk lesion. In selected cases immediate relief from pain occurs after administration of cortisone or a suitable cortisone-derivative. Prolonged rest may be contraindicated because of the risk of formation of radicular adhesions.

Adult↗