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Biomedical subjects

E Reale

Publications and source records attributed to E Reale.

At least 109 records · Page 6Linked to original sources
PubMed1975

Zonulae occludentes of the myelin lamellae in the nerve fibre layer of the retina and in the optic nerve of the rabbit: a demonstration by the freeze-fracture method.

Ridges and grooves composing extensive zonulae occludentes are revealed by the freeze-fracture method on split myelin lamellae in the nerve fibre layer of the retina and in the optic nerve of the rabbit. The junctions are located immediately internal to the outer loop of the myelin sheath and in corresponding areas of deeper myelin layers. They follow a straight or gently undulating course along the axis of the fibres. Only at the paranodal region of nodes of Ranvier do they deviate and assume a transverse course, The strands of these zonulae occludentes probably represent the radial thickenings of the intraperiod line described in thin sections.

Animals↗
PubMed1975

Freeze-fracture faces of the perineurial sheath of the rabbit sciatic nerve.

Replicas of the perineurium of rabbit sciatic nerve fascicles show extensive zonulae occludentes between the flattened cells of each perineuriallamella. The junctions formed by the zonulae occludentes are of the morphologically 'tight' type. Therefore, theyare likely to represent the anatomical site of the diffusion barrier previously demonstrated by other morphological and physiological methods. Neighbouring perineurial lamellae are connected to one another by numerous maculae occludentes, some of which lie on thelateral processes of the perineurial cells. Within the meshes of the maculae occludentes and close tothem, small gap junctions can be observed.

Animals↗
PubMed1975

Freeze-fracture analysis of junctional complexes in human ciliary epithelia.

The junctions connecting the epithelial cells of the human ciliary body were studied on replicas of freeze-fractured preparations. Gap junctions are present at the lateral surfaces of the cells of the pigmented epithelium. Gap junctions, isolated linear strands and desmosomes are found between the apical surfaces of pigmented and non-pigmented epithelial cells. Gap junctions, zonulae occludentes and desmosomes join the lateral surfaces of the non-pigmented epithelial cells. These findings suggest that the blood-aqueous barrier is located at the level of the zonulae occludentes of the non-pigmented epithelial cells. This is consistent with previous studies using thin sections and tracer substances. The function of the many gap junctions connecting the cells of the two epithelial layers is obscure since their presence is not consistent with electrophysiological data from this region.

Aqueous Humor↗
PubMed1975

The fine structure of the glomeruli as revealed by freeze-fracturing.

Isolated glomeruli of the rat kidney were investigated using the freeze-fracture method. The observations were consistent with those made on thin sections. Only exceptionally components of zonulae occludentes were seen between the capillary endothelial cells. The split membrane of mesangial cells revealed aspects of gap junctions.

Animals↗
PubMed1975

Fracture faces of fenestrations and junctions of endothelial cells in human choroidal vessels.

Replicas of freeze-fractured endothelial cells of human choroidal capillaries show fenestrations with a central thickening, as described in thin-section studies. Between the endothelial cells there are discontinuous zonulae occludentes (i.e., maculae or fasciae occludentes), composed of ridges on face A and grooves on face B of the split-cell membrane. They are also present along the sutures of the endothelial cells of venules. Close to the intercellular suture gap junctions, probably connecting capillary endothelial cells and pericytes, are found.

Capillaries↗