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Biomedical subjects

E Richards

Publications and source records attributed to E Richards.

At least 37 records · Page 2Linked to original sources
PubMed1993

Contribution of preoperative investigations to the anaesthetic management of adult trauma patients.

In a prospective study of 50 adult trauma patients, the effects of a protocol calling for eight rapidly available special investigations and 11 laboratory, electrocardiographic and radiological investigations were assessed as to their influence on anaesthetic management. The only investigation which gave information additional to that obtained by the clinical examination was the arterial blood gas, especially the pH, arterial oxygen tension and arterial carbon dioxide tension. Other contributory investigations were the protocol haemoglobin and protocol blood sugar estimation. The protocol electrolytes and clotting profile as well as the laboratory full blood count, urea and electrolytes, electrocardiograph and chest radiograph did not make a contribution to the assessment and anaesthetic management of this patient group.

Adolescent↗
PubMed1992

Family nursing practice paradigm perspectives and diagnostic approaches.

Family nursing practice reflects different belief systems about the nature of the family and family health. Competing belief systems (paradigms) are examined as they relate to the concepts of concern to family nursing. Using a family case study, divergent diagnostic approaches emerging from the paradigms are described and demonstrated. Implications are delineated for the further development of family nursing practice.

Adolescent↗
PubMed1989

Absorption of dihydrotestosterone (DHT) after its intramuscular administration.

In order to produce a sustained release system for natural androgens, two groups of six hypogonadal males received intramuscular (IM) 40 mg crystalline dihydrotestosterone (DHT), either with particle size of less than 50 microns (DHT-M) or between 100 and 150 microns (DHT-C). Serum DHT was analyzed through 51 days of follow-up. In the DHT-M group, serum DHT was above pretreatment values for 17 days, whereas in the DHT-C group, this period was extended over 50 days. The area under the serum concentration-time curve and the half-life of absorption calculated for the DHT-C group were greater than those obtained for the DHT-M group (55.1 ng/day/ml and 21 days vs. 14.5 ng/day/ml and 6 days; P less than 0.01). The authors conclude that DHT injection appears to be an effective and convenient technique for restoring serum physiologic DHT levels. This approach is suitable for long-term substitution therapy.

Absorption↗
PubMed1989

Self-reports of differentiation of self and marital compatibility as related to family functioning in the third and fourth stages of the family life cycle.

Using Bowen's, Olson's, and general systems frameworks, this investigator tested relationships among individual, marital, and family functioning in the stressed childrearing stages of the family life cycle. Sixty volunteer married couples completed the Level of Differentiation of Self Scale (LDSS), Locke-Wallace Marital Adjustment Test (MAT), and Family Adaptability and Cohesion Evaluation Scales (FACES) III. A significant canonical correlation was found among differentiation of self and marital compatibility as they both relate to family functioning. Subsequent canonical correlations were significant for wives but not for husbands, indicating gender differences in relationships among perceived individual, marital, and family phenomena. The concept of adaptability as proposed by Olson's Circumplex Model of Marital and Family Functioning was not supported. A revised model is proposed.

Adaptation, Psychological↗
PubMed1987

Constraints on the performance of minor surgery by family physicians: study of a 'mock' skin biopsy procedure.

Despite the availability of a procedure room equipped for the performance of common surgery procedures, physicians in a family medicine training programme have reported that minor surgery training objectives are not being accomplished. To examine this issue, the frequency of minor surgery procedures was audited among 357 randomly selected medical records. The frequency of documented sigmoidoscopy in this group of active patients over the age of 50 years was 4.8%. A similar low frequency for the performance of skin biopsy was also observed. All 15 senior residents participated in an attitude survey and a timed exercise in which they sought to find the necessary items for performance of a skin biopsy. In a questionnaire the group agreed that sigmoidoscopy and skin biopsies were procedures appropriate for their family practice goals. In their offices, these residents required over nine minutes to partially locate equipment chosen for skin biopsy. The attitude survey revealed few constraints other than insufficient time to perform indicated elective procedures. Further study of procedure room utilization and family physicians' office surgery skills is recommended.

Attitude of Health Personnel↗
PubMed1985

Conservation of nodulation genes between Rhizobium meliloti and a slow-growing Rhizobium strain that nodulates a nonlegume host.

Parasponia, a woody member of the elm family, is the only nonlegume genus whose members are known to form an effective nitrogen-fixing symbiosis with a Rhizobium species. The bacterial strain RP501 is a slow-growing strain of Rhizobium isolated from Parasponia nodules. Strain RP501 also nodulates the legumes siratro (Macroptilium atropurpureum) and cowpea (Vigna unguiculata). Using a cosmid clone bank of RP501 DNA, we isolated a 13.4-kilobase (kb) EcoRI fragment that complemented insertion and point mutations in three contiguous nodulation genes (nodABC) of Rhizobium meliloti, the endosymbiont of alfalfa (Medicago sativa). The complemented R. meliloti nod mutants induced effective nitrogen-fixing nodules on alfalfa seedlings but not on siratro, cowpeas, or Parasponia. The cloned RP501 nodulation locus hybridized to DNA fragments carrying the R. meliloti nodABC genes. A 3-kb cluster of Tn5 insertion mutations on the RP501 13.4-kb EcoRI fragment prevented complementation of R. meliloti nodABC mutations.

Journal Article↗
PubMed1982

Mycotic aortic pseudoaneurysm with aortoenteric fistula caused by Arizona hinshawii.

A case of bacteremic infection of a nonaneurysmal atherosclerotic infrarenal abdominal aorta by Arizona hinshawii that resulted in formation of a false aneurysm and secondary aortoduodenal fistula is reported and analyzed. Patients with bacteremia, gastroenteritis, or localized infectious processes due to Arizona species should be considered at risk for possible secondary arterial infection from transient bacteremia. In addition, patients over 50 years of age with atherosclerosis or patients with previously implanted cardiac and/or vascular prostheses who develop bacteremia or gastroenteritis because of Arizona species may be candidates for aggressive treatment with antimicrobial agents. The late diagnosis of primary arterial infections is associated with a high mortality rate, and an aggressive surgical posture is clearly indicated. Antimicrobial management should be instituted promptly in conjunction with, not in place of, aggressive surgical therapy.

Aged↗
PubMed1980

An evaluation of a rehabilitation workshop.

Staff awareness of the steps involved in rehabilitation was assessed before and after a multidisciplinary workshop concerned with the aims, methods and principles of rehabilitation in psychiatry. Results were compared with similar assessments derived from a matched control group which was not exposed to any educational programme. The data suggest severe limitations in staff performance on the rehabilitation problem solving task which was used. Performance was not improved by the workshop, and the limitations of staff opinion as measures of the educational value of the workshop were clearly demonstrated. These results are consistent with other findings, and demonstrate the need to evaluate educational programmes provided in the Health Services.

Evaluation Studies as Topic↗
PubMed1970

Changes in proton-magnetic-resonance spectra during aminolysis and enzymic hydrolysis of cephalosporins.

1. Changes in proton-magnetic-resonance spectra were followed during the reaction of cephalosporins, deacetylcephalosporins, deacetoxycephalosporins and a Delta(2)-cephalosporin with ND(3) in D(2)O. 2. Changes in proton-magnetic-resonance spectra were also followed during the hydrolysis of a cephalosporin and a deacetylcephalosporin in D(2)O with a beta-lactamase. 3. Structures for the reaction products are proposed. 4. The signals obtained after aminolysis of the beta-lactam ring of a cephalosporin indicate that the reaction is accompanied by expulsion of the acetoxy group as acetate, formation of a double bond in the Delta(4)-position and the appearance of an exocyclic methylene group. 5. Aminolysis of deacetyl- and deacetoxycephalosporins can occur without immediate structural changes in the dihydrothiazine ring. 6. In contrast, the ring structure of the first product of enzymic hydrolysis of a deacetylcephalosporin is apparently identical with that of the product of aminolysis of the cephalosporin itself.

Ammonia↗
PubMed1970

The effects of abnormal sympathetic nervous function upon the ventilatory response to hypoxia.

THE VENTILATORY RESPONSE TO HYPOXIA WAS STUDIED IN TWO GROUPS OF SUBJECTS WITH ABNORMAL SYMPATHETIC NERVOUS CONTROL: (a) human subjects with familial dysautonomia (Riley-Day syndrome), and (b) unanesthetized goats treated with an alpha-adrenergic blocking agent (phenoxybenzamine). The ventilatory response to hypoxia was evaluated in two ways: (a) from the slope of the relationship between ventilation and alveolar P(Co2) ([unk]V(E)-P(ACo2) slope) during the rebreathing of hypoxic and hyperoxic gases, and (b) from the change in ventilation produced when hypoxia was abruptly relieved. The ventilatory and circulatory responses of the unanesthetized, phenoxybenzamine-treated goats were qualitatively similar to those of dysautonomic patients. In contrast to the sustained stimulation of ventilation produced by hypoxia in normal subjects, hypoxia either did not change, or decreased, the [unk]V(E)-P(ACo2) slope of dysautonomic patients and phenoxybenzamine-treated goats; CO(2)-free hypoxia produced a fleeting hyperventilation, which was followed by apnea when hypoxia was abruptly relieved. Unlike normal subjects, the dysautonomic patients and phenoxybenzamine-treated goats became hypotensive while hypoxic. The results indicate that peripheral chemoreceptor reflex responses to hypoxia are preserved in subjects in whom sympathetic nervous responses are impaired. However, the central nervous depression of ventilation by hypoxia is enhanced simultaneously. The inordinate central depression is attributed to the inability of the dysautonomic subjects and goats to maintain systemic blood pressure and, consequently, cerebral blood flow during hypoxia, thereby aggrevating central nervous hypoxia.

Animals↗