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Biomedical subjects

E Ritter

Publications and source records attributed to E Ritter.

71 records · Page 4Linked to original sources
PubMed1985

[Development of lung tumors in Syrian hamsters with a mixed Mycoplasma pneumoniae and influenza virus infection].

The authors studied morphological alterations in the lungs of Syrian hamsters infected intranasally with Mycoplasma pneumoniae and influenza virus. The animals were first infected with M. pneumoniae and after 7 days with influenza A/PR8 virus. On days 1-3 after infection with influenza virus (days 8-11 following infection with M. pneumoniae) the animals showed the appearance of multiple foci of bronchiolar epithelium proliferation. At the later stages of experiment the size of the foci of proliferation increased. On days 14-21 after infection with influenza virus (days 21-28 of experiment) the animals developed lung tumors.

Animals↗
PubMed1984

The morphological effects of chenodeoxycholic acid on human gastric mucosa.

Morphology of human gastric mucosa was examined by light microscopy before and after exposure to suspensions of chenodeoxycholic acid tablets. During gastroscopy with a flexible instrument the gastric mucosa of eight control subjects without gastric disease was biopsied. In five other patients the chenodeoxycholic acid tablet suspension was instilled immediately after control biopsies of mucosa. Subsequent biopsies were collected after 10-15 min exposure to the suspension. Surface mucosal cells regularly showed development of clear cytoplasmic vacuoles, marked cytoplasmic condensations, and pyknosis of the nuclei. Appreciable changes in relative cytoplasmic staining density, loss of intactness of cells, and loss of surface mucous cell granules were observed less frequently. Thus, exposure of gastric mucosa to chenodeoxycholic acid tablet suspensions may be associated with histological changes in surface mucosal cells.

Animals↗
PubMed1979

Hypothermia-induced potentiation of histamine H2-receptor-mediated relaxation and cyclic AMP increase in the isolated mesenteric artery of the rabbit.

On helically cut strips of the rabbit's mesenteric artery, a temperature decrease from 42 degrees C to 25 degrees C reduced the contractile responses to histamine. Metiamide shifted the dose-response curve of the histamine-induced contraction towards higher values at 25 degrees C, but not at 42 degrees C. Furthermore, on arterial strips contracted by phenylephrine histamine evoked a dose-dependent relaxation at 25 degrees C whereas at 42 degrees C only slight relaxing responses to histamine occurred. Metiamide was capable of preventing the relaxation induced by histamine in a competitive manner. At 25 degrees C the relaxation as produced by histamine was accompanied by increases in cyclic AMP which occurred prior to the relaxing effects. Metiamide abolished the cyclic AMP increase in response to histamine. At 42 degrees C histamine was unable to elevate the cyclic AMP content. Thus, it is concluded that a cyclic AMP-mediated relaxation due to stimulation of H2-receptors counteracts the histamine-induced contraction and reduces the contractile responses to histamine at low temperatures. In addition, clear-cut evidence exists from the present study that also on artery smooth muscle the H2-receptor-mediated responses are closely associated to cyclic AMP.

Animals↗
PubMed1979

Relationship between histamine-induced changes of cyclic AMP and mechanical activity on smooth muscle preparations of the guinea-pig ileum and the rabbit mesenteric artery.

On guinea-pig ileum and rabbit mesenteric artery contracted by high potassium (100 mM) histamine produced relaxations which were inhibited by the H2-receptor antagonist metiamide. These results are thus indicative for the role of H2-receptors in mediating relaxation and for H1-receptors in mediating contraction on smooth muscle. Time course studies for the relaxing and cyclic AMP responses to histamine showed that the cyclic AMP increase preceded the H2-receptor mediated relaxation. The cyclic AMP increase in response to histamine was prevented by metiamide, but remained unaffected by mepyramine on both the guinea-pig ileum and the rabbit mesenteric artery. In addition, dose-response curves obtained on the mesenteric artery demonstrated that the H2-receptor mediated depressor responses coincided with cyclic AMP increases. Thus, these results gave clear-cut evidence that cyclic AMP is an intracellular metabolic event only implicit in the H2-receptor mediated relaxation, but not in the H1-receptor mediated contraction on smooth muscle preparations.

Animals↗
PubMedDate not supplied

The RSVP facelift: a highly vascular flap permitting safe, simultaneous, comprehensive facial rejuvenation in one operative setting.

This study describes our effort to develop a reliably safe method for combining currently available treatment modalities in an effort to obtain comprehensive facial rejuvenation in one operative setting. Detailed evaluation of 101 available consecutive patients, their per- and postoperative photos and charts was undertaken. Five groups of patients were studied: (1) traditional facelift with wide subcutaneous undermining and SMAS plication. (2) Similar traditional facelift with regional laser resurfacing. (3) RSVP (rejuvenation with sparing of vascular perforators) facelift. Subcutaneous undermining stops 3 cm lateral to the nasolabial fold to preserve the rich angular/facial arterial supply and venous drainage, still permitting lateral SMASectomy or SMAS plication. Subcutaneous neck undermining is discontinuous, the posterior dissection being limited to that which is necessary for identification of the posterior edge of the platysma and its plication to the mastoid and SCM muscle. The anterior dissection is limited to that necessary for anterior platysmal repair leaving intact a vertical subcutaneous non-undermined zone 4-6 cm in width, preserving the submental perforating artery. If indicated, gentle liposuction with a fine cannula is performed through this area. (4) RSVP facelift and regional laser resurfacing. (5) RSVP facelift with total facial laser resurfacing. Mean follow-up was 13.6 months, minimum 6 months. There were no additional major complications associated with the addition of laser resurfacing or fat grafting to the RSVP group. The patients with laser resurfacing were pleased with their result, and estimated that their apparent age had been reduced by a mean of 10.4 years, compared with 6.6 years for the non-lased group. We conclude that the RSVP flap is a hardy, vascular flap permitting simultaneous laser resurfacing, fat grafting, and other adjunctive procedures without significant fear of flap loss.

Adipose Tissue↗
PubMedDate not supplied

[Drowning by aspiration of oral saline administration].

A fatal case of salt water ingestion of a 35-year old drug addict is presented. Resuscitation by emergency doctor after first-aid was not successful. Autopsy revealed the classical signs of drowning. In the sphenoid sinus sodium-chloride could be detected. The diagnosis and differential diagnosis of drowning is discussed.

Adult↗
PubMedDate not supplied

[Death caused by stomach rupture due to overinflation during oxygen administration via stomach tube].

Soon after transfer from an intensive care unit to a normal ward within a hospital a 59-year-old female patient died. The investigation revealed that oxygen was insufflated accidentally through a nasogastric tube into the stomach and the intestinum. Autopsy showed a distended abdomen and odorless free gas streaming out of the opened abdomen. In the gastric wall, a 12 cm long rupture and 5 more incomplete ruptures were found. A most possible mechanism of gastric rupture due to overstretching by insufflated gas is presented. Criminal responsibility was excluded as the cause of the death could not be stated without reasonable doubt. The problem of selecting patients for intensive care to the disadvantage of others who also might profit from this special treatment is discussed.

Female↗