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E Rocca

Publications and source records attributed to E Rocca.

At least 37 records · Page 2Linked to original sources
PubMed1983

Effects of gliadin-derived peptides from bread and durum wheats on in vitro cultures of human cell lines. Implications for coeliac disease pathogenesis.

A peptic-tryptic-cotazym digest, obtained from bread (hexaploid) wheat gliadins under experimental conditions mimicking in vivo protein digestion, was found to reduce in vitro viability of human embryo (MRC-5) and tumor cell (Hep-2) lines. Time of onset and extent of cytotoxic effects were largely dependent on initial peptide concentrations in the culture medium. The presence of 2% fetal calf serum was capable of delaying, but not of preventing, the onset of cytotoxic effects only in MRC-5 cultures. A peptic-tryptic-cotazim digest obtained from durum (tetraploid) wheat gliadins and tested under identical conditions did not show any cytotoxic activity on MRC-5 and Hep-2 cell lines. These results indicate that cell systems are useful to investigate pathogenetic mechanisms of coeliac disease (gluten-dependent enteropathy).

Celiac Disease↗
PubMed1975

Electrophysiological evidence for a neurohormonal dependence in the changes of the late glabellar response in man.

In 19 normal adults reserpine administration induced significant changes in the parameters of the second glabellar response (R2): shortening of the latency and duration; decrease of the excitability threshold and complete blockade of the physiological habituation of R2 to the electrical and mechanical stimulation. No changes in the first response (R1) were observed. All the R2 changes disappeared within about 3 days of drug administration. The Parkinson-like effect of reserpine on the glabellar reflex is discussed in the light of a neurohormonal hypothesis in the control of the polysynaptic pathways biasing R2.

Adolescent↗