[Ethics in scientific research].
Explore the source record for details and available documents.
Animal Rights↗
Biomedical subjects
E Romero Vecchione
Publications and source records attributed to E Romero Vecchione.
[Effect of cerebral noradrenaline and dopamine depletion on spontaneous and amphetamine-stimulated motor activity in rats].
Selective depletion of rat brain noradrenaline and dopamine by 6-hydroxidopamine, 30-60 days after cisterna magna microinjection, reduced nocturnal spontaneous locomotor activity by 40%. This treatment also reduced by 90% the excitatory effect of amphetamine on locomotion. Disulfiram and FLA-63, selective inhibitors of dopamine-B-hydroxilase, depleted by 70% the noradrenaline content of striatum and brain cortex, without changes of dopamine concentration in the same areas. These rats showed a reduced spontaneous locomotor activity and a blockade of amphetamine stimulating activity. In conclusion, our results give support to the hypothesis of brain noradrenaline having a major role on the control of locomotor activity of rodents.
Amphetamines↗
[Effect of intracisternal 6-hydroxydopamine on the cardiovascular response induced by carotid occlusion and asphyxia in rats].
Explore the source record for details and available documents.
Animals↗