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Biomedical subjects

E Rota

Publications and source records attributed to E Rota.

33 records · Page 2Linked to original sources
PubMed1988

Tomographic studies of rCBF with [99mTc]-HM-PAO SPECT in patients with brain tumors: comparison with C15O2 continuous inhalation technique and PET.

In 10 patients with malignant gliomas, the intracerebral distribution of [99mTc]-hexamethylpropylene-amine oxime [( 99mTc]-HM-PAO) was studied with single photon emission computed tomography (SPECT) in comparison with C15O2 steady-state inhalation technique to measure cerebral blood flow using positron emission tomography (PET). In all instances, the cerebral [99mTc]-HM-PAO distribution was comparable with the regional pattern of cerebral blood flow (rCBF) observed with PET. This was confirmed by a significant correlation of tumor to cortex and tumor to white matter ratios between these two experimental methods. However, the contrast between high and low activity regions in the SPECT scans was significantly less than that in the PET scans. Contrast enhancement of the SPECT scans was accomplished using a correction formula proposed by Lassen.

Brain Neoplasms↗
PubMed1987

Tomographic studies of rCBF with 99mTc-HM-PAO SPECT in comparison with PET in patients with primary brain tumors.

99mTc-hexamethyl-propyleneamine-oxime (HM-PAO) was developed as a radiotracer of regional cerebral blood flow (rCBF) with SPECT. THe purpose of this study was to investigate if HM-PAO is able to trace rCBF in primary brain tumors. In 10 patients with glioblastoma grade IV the intracerebral distribution of HM-PAO was studied in comparison with C15O2 steady state inhalation technique and PET for rCBF evaluation. In all instances the cerebral HM-PAO distribution was comparable with rCBF pattern as confirmed by a significant correlation of tumor to cortex ratios. The results indicate the clinical usefulness of HM-PAO for tracing rCBF in brain tumors.

Brain Neoplasms↗
PubMed1986

Neurological complications of cerebral angiography.

We report a prospective study of 218 consecutive patients undergoing cerebral diagnostical angiography, before during and 24 hours after the procedure, to identify the neurological complication rate and the risk factors related to the patients and to the procedure. We observed 15 neurologic accidents (6.9%) with permanent sequelae in one case (0.4%). Two risk factors proved to correlate significantly with accidents, i.e. the time that the catheter remained within a vessel and difficulty in performing the procedure.

Adult↗
PubMed1986

Functional studies in brain and heart with positron emission tomography.

Positron Emission Tomography (PET) has evolved in the last years into a powerful research technique for the study of the physiology and pathophysiology of the human brain in vivo. These procedures now need no longer be viewed only as research studies. They are ready to be applied clinically on a wide scale. This article will give a short overview of the technical and methodological background and outline the clinical research applications by using the most developed tracers in the field: glucose and its analogs, oxygen, fatty acids, various perfusion markers and receptors, all labelled with positron emitting isotopes. They allow the quantitative measurement of local tissue functions in an essentially non-invasive way.

Brain↗
PubMed1981

Carbon disulfide neuropathy in rats. A morphological and ultrastructural study of degeneration and regeneration.

The aim of this study was to elucidate the site and detailed nature of peripheral nerve damage induced in the rat by chronic CS2 inhalation exposure in the light of the relationship between pathological and neurophysiological data. Adult male rats were exposed to 700 ppm of CS2 2 h/d, 5 d/week for 12 weeks and then followed-up for 18 weeks. The first alteration observed was a decrease in the nerve conduction velocity, discovered after only 3 weeks of exposure. Pathological lesions were first observed in the 10th week and consisted of a typical "giant axon" axonopathy. Obvious pathological lesions of the myelin sheaths were revealed much later, in the 3rd week after the end of exposure, when some nerve fibers were dying back. Recovery took place with the regeneration of new fibers which started in the 8th week after the end of exposure and was nearly complete in the 18th week. These findings demonstrate that CS2-induced polyneuropathy is an axonopathy very similar to that caused by other occupational neurotoxic agents like MnBK, n-hexane, and acrylamide. The timing of the pathological events within the nerve fibers suggests that the pathogenesis of the nerve lesions should probably be attributed to a primary energy failure of the axonal membrane induced by CS2.

Animals↗
PubMed1981

Effects of ganglioside therapy on experimental CS2 neuropathy.

Both in animals and in man the inhalation of CS2 vapor induces a chronic polyneuropathy with primary lesions in the axons of peripheral nerves. Since it was reported in several studies that the administration of gangliosides improves nerve regeneration and the functional recovery of nerves damaged by section as well as cryodegeneration, a study was undertaken to evaluate the effects of bovine-brain gangliosides administration on the experimental CS2 neuropathy in the rat. One hundred and fifty male rats were intoxicated with CS2 by a discontinuous inhalation exposure to 700 ppm for 12 weeks until a clear neuropathy developed. Thereafter the animals were subdivided at random into five groups and treated in different ways: 10 mg/kg BW gangliosides, 0.5 mg/kg gangliosides, 0.5 mg/kg vitamin B1, and 1 mg/kg vitamin B6, physiological solution, and controls without any treatment. The recovery from neuropathy was controlled for 18 weeks of treatment and assessed periodically by means of clinical, electromyographic, and morphological examination. The results of morphological studies showed more pronounced regeneration activity in the rats treated with the high dose of gangliosides than in all others, while no differences among the groups could be observed as far as clinical and neurophysiological parameters are concerned. The mechanism supporting this ganglioside-induced effect has so far not been ascertained, and further studies on this subject are in progress.

Animals↗
PubMedDate not supplied

[Numerical variations in the platelets in blood taken from the jugular vein of cattle, in relation to the stage of the oestrous cycle].

The variations in the blood platelet counts were determined in cows during the oestrous cycle. The results confirmed the existence of variations and considerable fluctuations and also revealed an absolute minimal value constantly found at oestrus, and relative minima on the 7th and 14th day after oestrus. The changes in the blood platelet counts are discussed.

Animals↗