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Biomedical subjects

E S Arum

Publications and source records attributed to E S Arum.

5 recordsLinked to original sources
PubMed1977

Experimental animal infections with Mycoplasma hominis and Ureaplasma urealyticum.

Subcutaneous tissue cavities in mice and guinea pigs were infected with human isolates of Ureaplasma urealyticum and Mycoplasma hominis. The minimal infective dose for M. hominis was as low as less than 10 color-changing units (CCU) for mice and 10(2) CCU for guinea pigs. The minimal infective dose for U. urealyticum was as low as less than 10 CCU for mice and 10(4) CCU for guinea pigs. Mouse infections with either U. urealyticum or M. hominis persisted for 1 day to greater than 4 months. Guinea pigs remained infected for up to 4 weeks. Two M. hominis isolates were similar in their ability to infect subcutaneous tissue cavities but two U. urealyticum isolates varied in their ability to infect the cavities. The histopathology of the M. hominis and U. urealyticum infections was similar: an initial intense polymorphonuclear response with giant cells, followed in 4 weeks by histiocytes and giant cells with some plasma cells and lymphocytes.

Animals↗
PubMed1976

Nongonococcal urethritis.

Nongonococcal urethritis may now account for most cases of symptomatic urethritis seen at VD clinics in the United States. Well-controlled etiologic studies in nongonococcal urethritis have implicated Chlamydia in over 40% of cases but the etiology of Chlamydia-negative cases remains uncertain. Tetracycline provides effective antimicrobial therapy, but tests for cure are often inadequate, and distinguishing relapse and reinfection is difficult. For tetracycline-allergic patients, erythromycin should be used. Control measures to decrease transmission of nongonococcal urethritis are not well established.

Chlamydia Infections↗
PubMed1976

T-strain mycoplasma in the chimpanzee.

Specimens from 4 chimpanzees were cultured for T-strain mycoplasma and Mycoplasma hominis. T-strain mycoplasmas were recovered from the genital tract and throat of a male and the genital tract of his female cagemate; neither had clinical evidence of infection. Two other male chimpanzees were culturally negative for T-strain mycoplasmas. M hominis was not isolated from any of the animals. The chimpanzee may serve as a suitable experimental model for studying the role of T-strain mycoplasmas in human urethritis and reproductive failure.

Animals↗
PubMedDate not supplied

Experimental infection of the chimpanzee urethra and pharynx with Chlamydia trachomatis.

An isolate of Chlamydia trachomatis obtained from a man with nongonococcal urethritis was used to produce experimental urethral and pharyngeal infections in chimpanzees. After urethral inoculation of 8 X 10(1) inclusion-forming units (IFU), infections were established in three of three animals; urethral discharges developed in two. The infections persisted for five to nine weeks. Larger inocular (7 X 10(2) and 1 X 10(5) IFU) produced pharyngeal infections in two animals. The third animal's pharynx was not infected by 1 X 10(5) IFU. Chlamydial complement-fixing antibodies increased significantly in sera of two of three animals. This study provides an animal model for study of mucosal infection by C. trachomatis. The relative resistance of the chimpanzee pharynx to infection parallels clinical observations in man.

Animals↗