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E S Azevedo

Publications and source records attributed to E S Azevedo.

12 recordsLinked to original sources
PubMed1995

Familial aggregation of Leishmania chagasi infection in northeastern Brazil.

A sample of 1,604 individuals belonging to 243 nuclear families from an endemic area of visceral leishmaniasis (Jacobina, Bahia State, Brazil) was studied to disclose the intrafamilial pattern of infection. Significant father to offspring, mother to offspring, and sibling to sibling associations, in contrast a with nonsignificant father to mother association, clearly indicate a familial aggregation of the infection, with a strong suggestion of at least partial genetic involvement.

Adult↗
PubMed1984

Frequencies of atypical serum cholinesterase in a mixed population of northeastern Brazil.

Frequencies of the CHE1*A allele were estimated in 84 Whites and 772 Negroids from a random sample of Salvador, Bahia. The overall frequency of this gene in Negroids was estimated as 0.842 +/- 0.233%. This indicates that this sample presents around 50 +/- 17% of White admixture and that the estimate of the risk of developing prolonged apnoea in individuals submitted to suxamethonium is around 0.035%, that is about 1 out of 2,900.

Alleles↗
PubMed1982

Joint mobility in children: a population study.

The mobility of five joint pairs ( metacarpophalangeal, wrist, elbow, knee and ankle) was investigated in 3,000 mixed school children of Bahia, Brazil. A sampling method was designed to assure an equal number of fifty children in the smallest classes, when age, race and sex were held constant. Race was classified in five subgroups to assess the proportion of Black admixture. Multiple regression was carried out to analyze the data. The results showed a consistent effect of age on decreasing joint mobility, The effect of race was also on decreasing mobility of wrist, elbow and ankle; the darker the child, the less the joint mobility. However, the effect of sex showed no general consistency; for wrist, elbow and knee the girls had more mobility than the boys; for the ankle the boys had more mobility than the girls; and the metacarpophalangeal joint there was no sex difference. The complexity of multicausal effects on joint mobility are discussed considering the simultaneous interplay of biological and environmental actions.

Adolescent↗
PubMed1979

Association between HBsAg and race in a mixed population of Northeastern Brazil.

The frequency of Australian antigen carriers (HBsAg) was studied in three samples from northeastern Brazil. In sample A there were 1000 women from Tsylla Balbino Maternity in Salvador; in sample B there were 1,512 blood donors from Salvador, and in sample C there were 930 blood donors from Aracaju. In sample A, B and C the observed frequency of carriers (HBsAg) was 1.20%, 1.58% and 2.04% respectively. These differences were not significant (x22 = 2.2; p greater than 0.25). There was no association between the carrier state and sex, age, ABO and Rh blood groups, Chagas' disease and rural origin. However, the frequency of carriers (HBsAg) increases from White to Black, as follows: Whites = 0.5%; Mulattoes = 1.91%, and Black = 1.96% (x22 = 7.91; p less than 0.02).

ABO Blood-Group System↗
PubMed1977

Recessive form of Freeman-Sheldon's syndrome or 'whistling face',.

Freeman-Sheldon's syndrome is a rare genetic disease inherited as an autosomal dominant trait in some families but showing sporadic appearance in the majority of the reported cases. In the present paper we report a family having two affected children from normal consanguineous parents suggesting that Freeman-Sheldon's syndrome may be heterogeneous from the genetic point of view.

Abnormalities, Multiple↗
PubMed1976

Human alcohol dehydrogenase ADH1, ADH2 and ADH3 loci in a mixed population of Bahia, Brazil.

1. The three structural gene loci of human alcohol dehydrogenase have been studied in liver, jejunum and lung from 300 newborns in a triracially mixed population of Bahia, Brazil. 2. The frequency of the ADH23 allele was 0-1392, suggesting that the ADH23 allele is less frequent in Negroes. 3. A new ADH2 variant was identified. The electrophoretic pattern was interpreted as due to a new allele which is provisionally called ADH2Bahia. 4. By electrophoretic classification the 'atypical' variant was found in 2-8% of the sample. A question is raised regarding the ancestral origin of the 'atypical' variant in the population. Because this variant is common in Japanese it may have reached the present day population of Bahia through their American Indian ancestors. 5. Subjective estimation of the proportions of beta chains by giving scores to the liver isozymes alphaalpha, alphabeta and betabeta showed a clear relationship between the fetal weight and the beta chain activity. 6. The proportion of beta chains in the liver is significantly less when there is no enzyme activity in the lung, indicating some synchronous 'turning on' mechanism for alcohol dehydrogenase synthesis in both tissues.

Alcohol Oxidoreductases↗
PubMedDate not supplied

[Genetics and public health in Brazil (author's transl)].

The author discusses the effect of genetic disorders on public health, considering not only the affected persons but the importance of assisting their relatives. Sickle cell anemia and consanguineous marriage are specially considered in Northeastern Brazil due to its frequencies and possibilities of being explained to the public through genetic counselling.

Anemia, Sickle Cell↗