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Biomedical subjects

E S Barratt

Publications and source records attributed to E S Barratt.

At least 19 recordsLinked to original sources
PubMed2001

Psychometric properties of an Italian version of the Barratt Impulsiveness Scale-11 (BIS-11) in nonclinical subjects.

To assess the psychometric properties of the Italian translation of the Barratt Impulsiveness Scale-11 (BIS-11), the scale was administered to 763 college undergraduates. Based on analyses using item-total correlations and t-tests for differences between the top and the bottom total score quartiles, all items from the English version of the BIS-11 were retained in the Italian version. Cronbach's alpha for internal consistency was.79 and two-month test-retest reliability was.89. An exploratory principal-components analysis replicated the six first-order factors and three oblique second-order factors, consistent with the number identified in the English version. However, subfactor item loadings differed between the English and Italian versions. The overall item pool was consistent in being a homogeneous measure of impulsiveness. The BIS-11 total score was correlated significantly with aggression and ADHD measures. The BIS-11 also significantly differentiated between high and low levels of binge eating, alcohol consumption, and cigarette smoking.

Adult↗
PubMed2001

The impact of impulsivity on cocaine use and retention in treatment.

To determine whether impulsivity was related to severity of drug use and treatment outcome, 50 cocaine dependent subjects underwent baseline measures of severity of current cocaine use and the Barratt Impulsiveness Scale (BIS-11). The hypothesis of the study was that there would be a significant correlation between impulsivity and cocaine use severity. As predicted, there was a significant correlation between BIS-11 total scores and self-reported average daily cocaine use as well as cocaine withdrawal symptoms. A subset of 35 patients underwent a 12-week double-blind placebo controlled trial of buspirone and group therapy. Subjects with high baseline impulsivity remained in the study a significantly shorter period than did subjects with lower baseline impulsivity. This study shows that impulsivity is a significant predictor of cocaine use and treatment retention, and suggests the need for targeting impulsivity in cocaine dependence treatment.

Adult↗
PubMed2001

Psychiatric aspects of impulsivity.

OBJECTIVE: The authors discuss the relationship of impulsivity to psychiatric disorders and present selected hypotheses regarding the reasons for these relationships. METHOD: Previous research has shown significantly higher levels of impulsivity among patients with conduct disorder, personality disorders, substance use disorders, and bipolar disorder, compared to other psychiatric patients or healthy comparison subjects. A literature review of the theoretical bases of the relationship between these disorders and impulsivity is presented. Measurements of impulsivity and treatment options are discussed in relation to the physiology of impulsivity and the disorders in which it is a prominent feature. RESULTS: Impulsivity, as defined on the basis of a biopsychosocial approach, is a key feature of several psychiatric disorders. Behavioral and pharmacological interventions that are effective for treating impulsivity should be incorporated into treatment plans for these disorders. CONCLUSIONS: The high comorbidity of impulsivity and selected psychiatric disorders, including personality disorders, substance use disorders, and bipolar disorder, is in a large part related to the association between impulsivity and the biological substrates of these disorders. Before treatment studies on impulsivity can move forward, measures of impulsivity that capture the core aspects of this behavior need to be refined and tested on the basis of an ideologically neutral model of impulsivity.

Antipsychotic Agents↗
PubMed1999

Impulsive and premeditated aggression: a factor analysis of self-reported acts.

Although aggression research in general has been hampered by a lack of objective measurements of aggressive acts, two types of aggressive acts, impulsive vs. premeditated, have been studied extensively in recent years. These two types of aggression have been primarily measured by structured or semi-structured interviews. The current study was designed to assess the construct validity of these two types of aggression using a self-report questionnaire which included items gleaned from the content of interviews used in past studies. For this study, 216 college students assessed their own aggressive acts rather than answering general questions about aggression. The students were not significantly different from normative sample groups on self-report measures of impulsiveness, aggression, and anger/hostility. A PCA factor analysis with a promax rotation of the items on the self-report questionnaire identified four factors: impulsive aggression; mood on the day the act occurred; premeditated aggression; and agitation. Thus, impulsive and premeditated aggression are independent constructs which exist in varying degrees among these 'normal' persons in a non-clinical sample. Impulsive aggression was characterized in part by feelings of remorse following the acts and by thought confusion. Premeditated aggression was related to social gain and dominance.

Adult↗
PubMed1998

Defining, measuring, and predicting impulsive aggression: a heuristic model.

Aggression research does not lack data--it lacks a model for integrating data. One of the problems confronting aggression researchers is the extensive body of multidisciplinary data that is difficult to synthesize to generate new directions in research. This paper proposes one solution that starts by asking "what is the minimal number of categories of concepts and measurements which are necessary to describe a person?". The answer is four categories of concepts: biological; cognitive; behavioral; environmental (physical and social). One way of many for integrating these four categories of concepts is a proposed discipline neutral heuristic model that is used herein to compare two different research approaches to the study of impulsive aggression. This comparison identifies clearly the differences in the two approaches with regard to different emphases among the four categories of constructs for each program. Using the model an example of common ground between the two approaches is sought as a basis for extending aggression research. The main conclusion of one of the research programs was that central nervous arousal is related to impulsive aggression. This program demonstrated that phenytoin will reduce impulsive aggressive acts and has an effect on CNS arousal. The other research program on impulsive aggression has been at the forefront in demonstrating the well established inverse relationship between serotonin levels and aggression. The comparison resulted in the suggestion that both serotonin and phenytoin may relate to a common neurochemical substrate which interacts in part to control CNS arousal, especially at the cortical level. The proposed heuristic model made obvious the need to use synthesizing concepts (e.g. information processing or language) which can interrelate multidisciplinary concepts and data from different research programs within the four categories of constructs when comparing interdisciplinary research.

Aggression↗
PubMed1997

Neuropsychological and cognitive psychophysiological substrates of impulsive aggression.

The purpose of this study was to test whether subjects who commit impulsive vs non-impulsive aggression differ on measurements of personality, neuropsychology, and cognitive psychophysiology, and whether these differences can yield information regarding the etiology of impulsive aggression. Subjects were two groups of prison inmates, distinguished by their committal of impulsive or nonimpulsive aggression, and matched noninmate controls. All inmates met DSM III-R criteria for an antisocial personality disorder but for no other disorder. Impulsiveness, anger, and peak P300 latencies did not differ between the inmate groups, but verbal symbol decoding and peak P300 amplitudes did. Impulsiveness and verbal skills were inversely correlated. Impulsiveness was inversely correlated with, and verbal skills positively correlated with P300 amplitudes. The results indicate that aggression is not homogenous, even among antisocial persons, and that impulsive aggression is related to neuropsychological and cognitive psychophysiological measures of information processing beyond those factors related to criminality alone.

Adult↗
PubMed1997

The effects of phenytoin on impulsive and premeditated aggression: a controlled study.

Studies of the effects of phenytoin on aggression have produced equivocal results primarily because of a lack of (1) common objective criterion measures of aggressive acts across studies; (2) rigorous inclusion and exclusion criteria for selecting subjects; and (3) a nosologic basis for classifying different types of aggression. The current study was designed to remedy these deficiencies. Aggression was defined using a nosology that defines three types of aggression: (1) medically related; (2) premeditated; and (3) impulsive. The purpose of this study was to test the hypothesis that phenytoin will decrease impulsive aggressive acts but not have a significant influence on premeditated aggressive acts. Sixty inmates were divided into two groups on the basis of committing primarily impulsive aggressive acts or premeditated aggressive acts while in prison. Medical aggression was ruled-out by subject selection. The study used a double-blind, placebo-controlled, crossover design. As hypothesized, phenytoin (200 mg a.m. and 100 mg p.m.) significantly reduced impulsive aggressive acts but not premeditated aggressive acts. Event-related potentials (ERPs) measured information processing in the cortex during drug/placebo conditions. The amplitudes of P300 ERP waveforms among impulsive aggressive subjects were increased significantly during the phenytoin condition but not during the placebo condition. There were no significant changes in P300 ERP waveforms between drug/placebo conditions among nonimpulsive aggressive subjects.

Adult↗
PubMed1996

Verbal skills, finger tapping, and cognitive tempo define a second-order factor of temporal information processing.

Adolescents with academic and social problems are often characterized as impulsive, having poor verbal skills, and having poor motor coordination. Language and skilled movements have long been hypothesized to share a common neural basis. The purpose of this study was to test the hypothesis that verbal skills, fine motor tasks that require a continuous sequential response, and cognitive tempo (impulsiveness, time judgment) would interrelate to define a higher-order dimension of "temporal information processing." Subjects were 155 males of high school age. The results confirmed the basic hypothesis.

Adolescent↗
PubMed1995

Factor structure of the Barratt impulsiveness scale.

The purpose of the present study was to revise the Barratt Impulsiveness Scale Version 10 (BIS-10), identify the factor structure of the items among normals, and compare their scores on the revised form (BIS-11) with psychiatric inpatients and prison inmates. The scale was administered to 412 college undergraduates, 248 psychiatric inpatients, and 73 male prison inmates. Exploratory principal components analysis of the items identified six primary factors and three second-order factors. The three second-order factors were labeled Attentional Impulsiveness, Motor Impulsiveness, and Nonplanning Impulsiveness. Two of the three second-order factors identified in the BIS-11 were consistent with those proposed by Barratt (1985), but no cognitive impulsiveness component was identified per se. The results of the present study suggest that the total score of the BIS-11 is an internally consistent measure of impulsiveness and has potential clinical utility for measuring impulsiveness among selected patient and inmate populations.

Analysis of Variance↗
PubMed1994

The incompetent defendant: support systems help avoid future legal problems.

Reducing crime and improving efficiency of our criminal justice system should be facilitated by identifying how to treat and manage mental health patients who are prone to committing criminal acts more effectively. A total of 142 competency evaluations were reviewed from cases evaluated by the Galveston County Forensic Psychiatrist from 1984 to 1990. Examination of data from these defendants allowed us to address the psychiatric needs of these defendants in terms of contact with the mental health system, particularly those who had more than one criminal justice system contact. The latter defendants lacked social support systems and consistent mental health system follow-up to provide stabilization of their condition. It was felt that this was a factor in their more frequent contact with the criminal justice system.

Adolescent↗
PubMed1993

The use of anticonvulsants in aggression and violence.

Aggression and violence are not univariate concepts. A key to research into the effects of anticonvulsants on aggression and violence is using a nosology that provides a theoretical basis for the clinical use of anticonvulsants and leads to meaningful criterion measures for their evaluation. It is proposed that aggression can be divided into three broad categories: (1) medically related--the aggression is a symptom secondary to a psychiatric, neurological, or other medical disorder; (2) premeditated or planned--the aggressive act is an instrumental response; (3) impulsive--this is a hair-trigger response, that is, the subject does not process information in an adaptive way during the temper outburst. It is hypothesized that selected anticonvulsants (e.g., phenytoin and carbamazepine) will have a therapeutic effect on impulsive aggression. Preliminary data from our research indicate that phenytoin does decrease impulsive aggressive acts. Possible pharmacodynamic mechanisms for these results are briefly discussed within the context of electrophysiological measures at different levels of the central nervous system (event-related potentials, kindling, and ion channel functions). It is further proposed that the equivocal findings in the early studies of the effects of phenytoin on aggression were due to poor criterion measures and inappropriate inclusion/exclusion criteria for subjects (especially failure to document psychiatric or neurological disorders). The early results of our research on carbamazepine are encouraging, but not enough data have been gathered to document its effects on impulsive aggression. The therapeutic use of anticonvulsants to control aggressive and violent behaviors has a long and controversial history (Monroe 1975).(ABSTRACT TRUNCATED AT 250 WORDS)

Aggression↗
PubMed1989

Blood platelet uptake of serotonin in episodic aggression.

Blood platelet uptake of 3H-serotonin (5HT uptake), a potential marker of serotonergic function, was determined in male outpatients with episodic aggression (n = 15) and in age- and sex-matched nonaggressive controls (n = 15). Correlations with rating scales of "impulsivity" (Barratt Impulsivity Scale, 10th revision) and "anger" (Spielberger Anger Expression Scale) were performed. Mean 5HT uptake was 18% lower in patients with episodic aggression. A significant negative correlation between % difference in platelet 5HT uptake and impulsivity score was observed, but the correlation between 5HT uptake and anger was not significant. These results support the hypothesis of disturbed serotonergic function in aggression and suggest that the primary relationship is in the "control" of aggression. The blood platelet may be useful in identifying impulsive subtypes.

Adolescent↗
PubMed1986

Effects of phenytoin on N100 augmenting/reducing and the late positive complex of the event-related potential: a topographic analysis.

The effects of 100 mg of phenytoin on the topographic distribution of augmenting/reducing (amplitude response/nonresponse to increases in stimulus intensity) of the visual N100 component of the event-related potential (ERP) were examined. In normal subjects, visual N100 augmenting is associated with impulsivity and attentional distraction. Effects of phenytoin on the topographic distributions of the P300 and slow-wave cognitive ERP components were also examined. Subjects counted the total number of light flashes presented at two highly discriminable but equiprobable intensities. Results indicated that phenytoin had a significant reducing effect on the intensity response of N100 at the vertex and anterior temporal electrode sites, and approached significance at the frontal pole. That is, at these loci N100 showed less of an increase in amplitude (or, in some subjects, more of a decrease) in going from baseline to drug than in going from baseline to placebo. Results also indicated that phenytoin significantly enhanced the amplitude of the frontal, negative portion of slow wave, but not the posterior, positive portion or the P300 component. These findings are consistent with behavioral evidence that phenytoin reduces impulsivity and improves concentration.

Brain Mapping↗
PubMed1986

No decrement in visual P300 amplitude during extended performance of the oddball task.

Research indicates that in visual sustained attention paradigms, the amplitude of the P300 component of the event-related potential invoked by target (critical) stimuli shows a decrement in amplitude. This amplitude decrement parallels decrements in vigilance performance that result from the difficult discrimination that is typically required between the infrequent targets and the frequent nontargets (neutral stimuli). In contrast, target stimulus P300 does not appear to show a decrement across large numbers of trials during performance of the "oddball" paradigm, in which targets and nontargets are highly discriminable. The present study measured target and nontarget P300 amplitude during performance of a visual oddball paradigm extended over an interval of some 3 1/2 hours, a period well in excess of the 3/4 hour intervals employed in previous research. The results indicated no decrement in P300 amplitude as a function of time for either targets or nontargets. The only significant relationship between P300 and behavioral data was an inverse correlation across oddball runs between average nontarget P300 amplitude and total number of targets missed.

Adult↗