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Biomedical subjects

E S Canales

Publications and source records attributed to E S Canales.

At least 19 recordsLinked to original sources
PubMed1991

[Effect of ultrafiltered peritoneal fluid from patients with pelvic endometriosis on the in vitro motility of their spouse's sperm].

Recently, there has been information about the ultrafiltrated peritoneal fluid in patients with endometriosis, containing macromollecules that diminish tubal fimbria action, and the in vitro ovular captation in experimental animals. In order to investigate the presence of these substances in the peritoneal fluid, and to know the possible effect that could have on spermatic motivility in vitro, of their mates; 11 sterile women with diagnosis of pelvic endometriosis, and 11 normal fertile women, were studied. On the other side, the same day of study, the mate of each of these women, produced semen obtained by masturbation, where amount and motility of sperm, in basal conditions, and after, it was capacitated with Ham-F10, were determined. The final results was evaluated as to percentage of spermatozoon with excellent and progressive motility, and percentage of motionless spermatozoo as well as based on average values (mean +/- EE), of each one of them. The statistic analysis of differences was done by t Student that in coupled samples. The results confirm that peritoneal fluid of patient with endometriosis contains macromollecules, and it shows that these substances affect the motility in vitro of mate's spermatozoon, which could explain, partially at least, the origin of sterility in this disease.

Adult↗
PubMed1983

Follow-up of patients with prolactinomas after discontinuation of long-term therapy with bromocriptine.

The effects of bromocriptine discontinuation after a 2 year course of therapy on prolactin (Prl) serum levels and the radiological size of the sella turcica were investigated in 16 women with amenorrhoea-galactorrhoea due to prolactinoma. During therapy, all but 2 patients had normalized serum Prl levels, and 4 women with macroprolactinomas exhibited a reduction in the size of the tumour as documented by CT-scanning and tomography of the sellae. After bromocriptine withdrawal and follow-up during 2 additional years, Prl levels remained normal in 6 patients, 2 of them with microprolactinomas and 4 with macroprolactinoma. The remaining 10 women developed hyperprolactinaemia associated with amenorrhoea and galactorrhoea within 3 months after discontinuation of therapy. No tumour expansion was observed in any case during the 4 year observation period. In the present study bromocriptine treatment seemed to result in permanent cure in 6 out of 16 cases of prolactinomas; nevertheless it is difficult to justify an indefinite medical treatment since the natural history of prolactinoma remains unknown. We presently feel that bromocriptine is more appropriate than neurosurgical transsphenoidal exploration for the primary treatment of prolactinomas. Further investigation is needed before a more definitive conclusion regarding the management of prolactinomas can be reached.

Adult↗
PubMed1981

Anovulatory effect of a LHRH antagonist in women.

The antagonistic analog of LHRH, NAc-D-p-Cl-Phe(1),(2), D-Trp(3),D-Phe(6), D-Ala(10)-LHRH was administered intramuscularly in a dose of 2 mg to ten normally ovulating women on day 12 of the menstrual cycle. Ovulation was inhibited in six patients, and two more presented an insufficient corpus luteum. No pregnancies were recorded in this series. In those patients who did not ovulate, it was demonstrated that the LHRH analog abolished the midcycle surge of both LH and FSH. Luteolysis evidenced by the rapid decline in progesterone levels was present in 2 cases. Bleeding pattern showed a tendency to delayed menses. The morphological findings in endometrial biopsies of 6 women exhibited mild proliferation. Further research along these lines is necessary for appraisal of this approach to birth control.

Adult↗
PubMed1981

Feedback effect of estradiol on follicle-stimulating hormone and prolactin secretion during the puerperium.

Injections of 3 mg of estradiol benzoate were given to seven lactating women during the second and third weeks postpartum to study its effects on secretion of follicle-stimulating hormone (FSH) and prolactin during the subsequent 4 days. Administration of estradiol during te second week postpartum had no effect on serum levels of FSH and prolactin, however, 1 week later estradiol injection elicited a double effect: FSH levels decreased and prolactin concentrations increased. Early lactation seems to abolish the estrogen induced positive feedback effect on pituitary gonadotropin secretion. The negative effect of estrogen on FSH secretion and the positive effect on prolactin release became evident by the third week postpartum.

Estradiol↗
PubMed1981

Nomifensine test does not differentiate hyperprolactinemia associated with and without radiologic abnormalities in the sella turcica.

A group of 17 hyperprolactinemic women was given 200 mg of nomifensine orally to evaluate its diagnostic potential to discriminate between tumors and nontumorous hyperprolactinemia. The nomifensine suppressive effect on prolactin serum levels was not significantly different between patients with or without enlargement of the sella turcica. A control group of 5 women with normal prolactin levels exhibited a nomifensine suppressive effect below 65% of the baseline prolactin level, which was significantly different from that in the hyperprolactinemic group. In conclusion it is confirmed that the nomifensine test provides no value in the early diagnosis of the prolactinoma.

Adenoma↗
PubMed1980

Abnormal prolactin levels in serum and seminal plasma in infertile men.

The role of prolactin in male infertility was studied in 33 patients in whom serum and seminal plasma prolactin levels were determined. With the exception of those patients with Klinefelter's syndrome, infertile males presented moderate hyperprolactinemia as compared with a control group of 34 men. Prolactin levels in seminal plasma were greater than in serum in all patients studied; however, prolactin levels in infertile patients were significantly less than in normal males. Therefore, this situation is the reverse of what happens in serum. Seven patients with idiopathic oligospermia were treated with 5 mg of bromocriptine daily during 6 months, resulting in no measurable effect on the sperm count. Infertility in men may be associated with moderate hyperprolactinemia but bromocriptine is of no therapeutic use. Interpretation of the abnormal levels of prolactin in seminal plasma in oligo- and azoospermic men requires further investigation.

Adult↗
PubMed1980

Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women.

Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 microgram of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

Adult↗
PubMed1980

The use of a potent stimulatory LHRH analog (D-Trp-6, LHRH) in the induction of ovulation.

In 25 women with disturbances of ovulation who were treated for sterility with D-Trp-6-LHRH, a potent analog of LHRH, ovulation was achieved in nine patients, but none of these became pregnant after therapy. After using the LHRH analog combined with clomiphene citrate in 14 of these 25 women, six ovulated and only one conceived. The overall rate of ovulation after the combined therapy was better than obtained when LHRH analog alone was administered. From this study we conclude that more investigations using different regimens have to be carried out in order to establish the clinical benefit of LHRH stimulatory analogs in induction of ovulation.

Adult↗