Biomedical subjects

E S Grech

Publications and source records attributed to E S Grech.

At least 19 recordsLinked to original sources

PubMed1991

Pharmacological measures to prevent post-operative urinary retention; a prospective randomized study.

One hundred patients undergoing vaginal surgery for genital prolapse were randomly allocated to one of four post-operative management groups which included a control group and three groups receiving differently acting pharmacological agents (distigmine bromide, phenoxybenzamine hydrochloride, and prostaglandin F2 alpha) variously reported as being useful in preventing urinary retention after vaginal surgery. The incidence of an elevated residual volume in the control group was 10.7%. All the pharmacological agents appeared to increase by about three times the incidence of an elevated residual urinary volume with statistical significance (P less than 0.05) being noted for distigmine bromide and PGF2 alpha. While this increased incidence occurred irrespective of the type of surgery in the case of distigmine bromide and phenoxybenzamine . HCl, the increase was most marked (P less than 0.01) when PGF2 alpha was used after anterior repair surgery.

Dinoprost↗

PubMed1990

Computerization of data: a person-based medical record system.

The collection and evaluation of obstetric data is essential for assessing the effectiveness of the health and social services in a country. A computerized system in use on a national level is described. The person-based system aims to include all patients who encounter government medical services, including obstetric and infant data. The scope of the service is to make individual patient records easily available to the practitioner, but is designed to allow statistical analysis of the data.

Data Collection↗

PubMed1990

Risks in pregnant teenagers.

The teenage population delivering in Malta during 1983-1986 were identified and the maternal characteristics and obstetric outcome of these patients were statistically compared to those of mothers aged 20-29 years. Teenage mothers were more likely to be primigravida and poor attenders for antenatal care. They were more likely to be cigarette smokers and the pregnancies were more frequently complicated by threatened abortion. The perinatal mortality and morbidity was increased from problems of prematurity.

Adolescent↗

PubMed1989

Anti-Co3 and severe hemolytic disease of the newborn.

Irregular antibodies have been described to cause hemolytic disease of the newborn of varying severity. A case of anti-Colton 3 causing moderate to severe hemolysis in the newborn in two pregnancies is described. Only two cases of hemolytic disease of the newborn have been previously described; these resulted in mild hemolysis. The management of the condition is reviewed in the light of the current management of hemolytic disease of the newborn.

Adult↗

PubMed1988

Multiple pregnancy in the Maltese population.

This study analyses the multiple birth statistics for the Maltese Islands since 1959. Hospital twin births delivering during the period of 1983-1985 are analysed for a number of variables. The incidence of multiple pregnancy for the Maltese Islands appears to have decreased slightly since 1959 with an overall rate of 10.21 per 1000 maternities. The ratio of dizygotic to monozygotic twinning was computed to be 1.64. Patients with multiple pregnancies are shown to be generally elderly and multiparous. The pregnancy outcome is more likely to be complicated by an operative delivery, while the infant is more likely to be premature and of low birth weight. The perinatal mortality rate for multiple pregnancies is markedly in excess of that for singleton births.

Cause of Death↗

PubMed1987

Maternal mortality in the Maltese Islands.

Maternal mortality statistics from the Maltese Islands since 1935 are reviewed to show that there has been a marked decrease in maternal mortality rates. This decrease is probably related to reductions in family size and improvements in the perinatal care of mothers. Hypertensive disease is now the most important cause of maternal mortality.

Adult↗

PubMed1986

Endometrial adenocarcinoma in the Maltese population an epidemiological study.

The Maltese population has been shown to have a high incidence of endometrial adenocarcinoma when compared to other European countries. This high incidence has been correlated to the high prevalence of abnormal glucose metabolism and rather high dietary fat intake in the Maltese population. Hypertension and low parity were also found to be more frequent in the carcinoma group.

Adenocarcinoma↗

PubMed1985

Perinatal mortality in the Maltese Islands.

This study analyzes the perinatal mortality statistics for the Maltese Islands since 1950 and compares them to those of other European countries. The mortality rate has taken a variable downward trend which can be correlated to important events during this period. Hospital perinatal mortality statistics are reviewed in the light of the national statistics.

Europe↗

PubMed1984

Homozygous beta thalassaemia and pregnancy.

Pregnancy complicating homozygous beta thalassaemia is a rare entity. Two cases are described, 1 of which was further complicated by thrombocytopenia due to secondary hyperslenism. These cases are discussed in the light of current management of homozygous haemoglobinopathies.

Adult↗

PubMed1981

Pharmacokinetics of ethynyloestradiol in women for different populations.

The pharmacokinetics of a dose of 50 microgram ethynyloestradiol administered orally was studied in fourteen centres. Absorption was rapid and the highest serum concentrations of total ethynyloestradiol were found in most subjects at 1 h and by 24 h concentrations were less than 250 pg/ml. Calculation of the half-lives for absorption, distribution and elimination showed wide variations between subjects, the half-life of elimination varying from 2.5 h to more than 30 h. Bioavailability as measured by the area under the serum ethynyloestradiol concentration-time curve also showed more than a ten-fold variation. Intra-centre differences in the various parameters measured were as large as the inter-centre differences.

Biological Availability↗

PubMed1979

Rate of metabolism of norethisterone in women from different populations.

The rate of metabolism of orally administered norethisterone was compared in fourteen centres by measuring plasma levels of the steroid by radioimmunoassay at varying times after oral administration of a 1 mg dose. The inter-centre differences were of the same order as the intra-centre differences. Variations in metabolism appeared not to be due to variations in body size.

Adult↗

PubMed1978

Preoperative cervical dilatation with 15(S)15-methyl PGF2alpha methyl ester pessaries.

A clinical trial comparing two vaginal dose schedules of 15(S)15-methyl prostaglandin F2alpha (PGF2alpha) methyl ester (4 or 6 mg) for preoperative dilatation of the cervix is described. The trial included 28 patients at 8-12 weeks' gestation. Vaginal pessaries containing either 1.0 mg (15 patients) or 1.5 mg (13 patients) of the prostaglandin analogue were administered every 3 hours (maximum, 4 doses). The success rates for the two groups were 93% and 100%, respectively. Sixty percent of the patients aborted before the planned vacuum aspiration. Minor side effects, primarily vomiting and diarrhea, occurred in approximately 80% of the cases and were more prominent with the higher dose pessary. It is concluded that the vaginal administration of 15(S)15-methyl PGF2alpha methyl ester is highly effective for preoperative dilatation of the cervix before suction curettage abortion.

Abortion, Therapeutic↗

PubMed1977