[The role of neurodynamic factors in reparative morphogenesis].
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Biomedical subjects
Publications and source records attributed to E S Miliudin.
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A new model of biorhythm of wound process is proposed with due consideration for the neurodynamic features of its stages. The first phase of repair process is denoted as the tonic (trophotropic) and the second as the physical (ergotropic). In an aseptic wound the repair morphogenesis takes about two weeks, with the tonic effects predominating during the first week and ergotropic processes during the second week. This results in complete taking in of the autotransplant with formation of a fine cicatrice which does not deform the transplanted flap. Impairment of the biorhythm of wound process can involve excessive development of both trophotropic and ergotropic tendencies, rendering a pathologic direction to repair processes. Either tonic or physical component of trophic provision is then boosted and fixed, and hence, wound healing is delayed, which leads to formation rough deforming cicatrices.