PubMed Health⌕ Search

Biomedical subjects

E S Novak

Publications and source records attributed to E S Novak.

3 recordsLinked to original sources
PubMed1987

[System analysis of the process of oxygen supply in young sportsmen during physical exercise of various intensities].

Young sportsmen were found to have nonhomogeneous and qualitatively different participation of the hemodynamic, respiratory and tissue mechanisms in formation of the oxygen supply system on discretely increasing physical exercises. In maximal exercises, the O2 utilization in tissues is the main limiting section on oxygen consumption. Mathematic formulae are suggested to estimate the volume of blood circulation per minute according to the magnitude of oxygen consumption and respiratory capacity per minute.

Adolescent↗
PubMed1985

Solvent structure and enzyme activity.

Enzymes are fluctuating particles in thermal equilibrium with their solvent environment. A variety of models of enzyme action have postulated selective excitation of enzyme vibrational modes or triggering of correlated motion of catalytic groups through collisions with solvent particles as the basis of catalytic activity. Solvent composition and structure are expected to influence such interactions. Solutes such as p-dioxane, t-butanol, and tetraalkylammonium chlorides are known to be strong perturbants of the structure of water. However, when the kinetic parameters of two enzymes, carboxypeptidase A and alpha-chymotrypsin, were examined carefully in aqueous mixtures containing these solutes, no significant influence of solvent structure or mass composition on the catalytic rate constant was found. The results indicate, furthermore, that, within the low viscosity limit, fluctuations in enzyme structure that are responsible for activated processes in the catalytically rate limiting step appear not to be significantly influenced by dynamic processes in the bulk solvent.

Binding Sites↗