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Biomedical subjects

E S Nuwayser

Publications and source records attributed to E S Nuwayser.

6 recordsLinked to original sources
PubMed1978

Evaluation of polymer flock and metal alloy intra-tubal device in pigtail monkeys.

Two intratubal devices, one covered with a flock made from ethylene vinyl acetate and the other constructed of titanium-aluminum-vanadium alloy with an etched surface were evaluated after being placed in the Fallopian tubes of pigtail monkeys. In some instances, the devices were medicated with 10% silver nitrate or 50% quinacrine hydrochloride. The microflock device anchored in the tube mechanically, but there is no evidence that either the polymeric or metal alloy device formed an actual attachment with Fallopian tube epithelium. It is suggested that a mechanical design approach to ITDs might be more productive than one which assumes a tissue-device bond.

Alloys↗
PubMed1975

An absorbable artificial vas deferens for vasovasotomy.

An absorbable artificial vas deferens is being developed in order to improve the relativley poor conception rates of vasovasotomy. The capillary device which is 0.4 mm I.D. by 0.7 mm O.D. and 15 mm long vas made from 3 absorbable polymers: starch, collagen, and a copolyester of lactide and glycolide. Preliminary evaluation of the device was made by implantation in the guinea pig was deferens immediately following vasectomy. Absorption of the starch and the copolyester occurred within 2-4 wks after implantation, whereas collagen required 3 mos and sometimes longer. Gross and histological examination showed little or no adverse effect on the tissues of the vas deferens, epididymes and testes. Active spermatogenesis continued in most cases and sperm count and motility remained essentially unchanged. Breeding studies with males implanted with the device for 5 mos have resulted in 12/13 prrgnancies with starch, 19/19 pregnancies with the copolyester and 9/11 pregnancies with collagen.

Animals↗
PubMed1975

An absorbable intravasal stent and a silicone intravasal reversible plug. Report of experiments on animals.

The high failure rate of vasovasotomy to restore fertility in vasectomized men prompted this investigation using guinea pigs as the experimental animals. The vasa were divided and absorbable intravasal stents were inserted into the lumens of the vasa at the site of anastomosis. The success or failure to secure patency and reestablish fertility was appraised by histologic sections, vasograms, semen analyses, and breeding tests. A second group of animals had silicone plugs equipped with a detachable central pin placed in both vasa. The design of this procedure was to produce an occlusive azoospermia which might be reversed by removing the central pin. Similar tests were used to establish the effectiveness of this reversible device in producing a temporary sterilization. The procedures were controlled by sham operations and insertion of plugs without pins.

Animals↗