[Basal gastrin content of the blood in kidney diseases].
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Biomedical subjects
Publications and source records attributed to E S Ryss.
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The author summarizes experience gained recently in the treatment of peptic ulcer patients with cholinolytics and antacids and agents with a restricted pathogenetic action. Discusses the tactics of their use, advantages of the application of high doses of antacids (210 ml a day). Provides the data on the advantages of long-term staged treatment of peptic ulcer patients, ensuring real prevention of the disease relapses.
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The authors analyzed 380 autopsies for chronic glomerulo- and pyelonephritis and studied the clinical and functional features of gastric pathology in 240 patients with the same disease entities. The hypotheses are suggested about a 3-stage successive formation of uremic gastropathy. The importance of hypergastrinemia as one of the pathogenetic factors, as a vicarious organ as regards nitrogenous products at early stages of chronic renal insufficiency is discussed.
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In a series of chronic experiments on 30 rats subjected to nephrectomy, use was made of the present-day morphological and quantitative histochemical techniques to study the activity of oxidation-reduction enzymes, hydrolases and PAS-reaction in cellular elements of the mucous membrane of the fundal and antral parts of the stomach. It was found that in the early stages of experimental renal insufficiency, all the main cells of the glands manifested marked hyperplasia. These alterations seem likely to be adaptive in nature and are caused by the stimulatory action of the increased amounts of nitrous residue in the gastric lumen of such animals. The authors discuss the origin of gastric pathology in experimental animals and make clinical and experimental correlations.
Patients with chronic renal failure often reveal a peculiar "uremic gastropathy" characterized by a decreased secretory activity of the gastric glands. Most of such patients should not be referred to the group of high risk of ulceration. This point is extremely important, when cases are screened for kidney transplantation. Immunomorphological changes occurring in the gastric mucosa provide just one of the possible etiological factors, which also include uremic intoxication and, probably, the intragastric effect of nitrous metabolic products. A long-term (months) therapy by programmed hemodialysis is not, as a rule, accompanied by the development of gastric hyperchlorhydria and hypersecretion.