Biomedical subjects

E S Teoh

Publications and source records attributed to E S Teoh.

At least 19 recordsLinked to original sources

PubMed1988

Asian approaches in the treatment of trophoblastic disease.

The cure of trophoblastic disease depends on early recognition and appropriate chemotherapy. In many areas in Asia, doctors face the problems of insufficient funds and poor patient compliance with follow-up. In such situations, the maximum returns for the minimum input would consist of: 1. Routine ultrasound diagnosis for irregular vaginal bleeding associated with amenorrhea; 2. In hydatidiform mole, hysterectomy for women above 40 and those who have completed their families; prostaglandin and suction curettage for evacuation; 3. Prophylactic methotrexate-folinic acid, or dactinomycin or 5-FU for high-risk cases; 4. Follow-up by the simplified regimen using hCG test kits; 5. Chemotherapy with hysterectomy for choriocarcinoma, whether localized in the uterus or metastatic: if the uterus is to be conserved, there must be a good reason; 6. Multiagent chemotherapy as first line in all high-risk cases; and 7. In view of the excellent results with 5-FU in China, investigation of this drug elsewhere, initially in metastatic mole.

Asia↗

PubMed1976

Serum human chorionic somatomammotropin in unaborted hydatidiform mole.

Serum human chorionic somatomammotropin (hCS) was measured in 35 patients with intact unaborted hydatidiform mole by a rapid radioimmunoassay using 70% dioxane in water to separate the bound from unbound fraction. Serum hCG was measured by a hemagglutination inhibition method. Serum hCS ranged from 250 to 5900 ng/ml, while serum hCG ranged from 60 IU/ml on unaborted molar pregnancies. Serum hCS in hydatidiform mole increases from a mean +/- SE of 650 +/- 88.5 ng/ml at 7 to 9 weeks' gestation to 1986.7 +/- 859.3 ng/ml at 22 to 25 week's gestation. There was a significant correlation between uterine size and serum hCS in molar pregnancies (correlation coefficient r = +0.5183; P = 0.0025). There was no significant correlation between serum hCS and serum hCG. Serum hCS in a patient with molar pregnancy who subsequently developed choriocarcinoma was not significantly different from that in patients who did not. The findings indicate: 1) that peripheral hCS increases with increased gestational age in molar pregnancies, 2) that the amount of peripheral serum hCS is related to the mass of molar tissue present and not dependent on serum hCG level, and 3) that the serum hCS level in unaborted hydatidiform mole was a poor index for predicting malignant sequelae.

Choriocarcinoma↗

PubMed1975

Disappearance of serum progesterone: after normal delivery and removal of hydatidiform mole.

Serum progesterone was measured by competitive protein binding assay at regular intervals up to 24 hours after delivery in 4 normal pregnancies. In 6 cases of hydatidiform mole, serum progesterone was assayed before and at regular intervals up to 48 hours after uterine evacuation or hysterectomy. Serum progesterone dropped rapidly by more than 50% during the first hour postpartum, and it was less than 25% of the predelivery levels 24 hours after parturition. In all 6 cases of molar pregnancies, serum progesterone fell rapidly within the first few hours after uterine evacuation. In the presence of theca lutein cysts (2 cases), serum progesterone fell much more slowly than in the absence of theca lutein cysts after removal of the mole tissue. Serum progesterone was less than 5mg/ml after total hysterectomy of uterine evacuation in moles without theca lutein cysts. These findings suggest that while the placenta is the principal source of elevated serum progesterone in normal pregnancy, the molar trophoblast is the principal source of elevated serum progesterone in hydatidiform mole, with the theca lutein cysts making a contribution when they are present.

Abortion, Induced↗

PubMed1975

Progesterone concentration in placenta, molar tissue, and ovarian theca lutein cyst.

Progesterone concentrations in 2 full-term normal placentas, molar tissue from 3 cases of hydatidiform mole were measured by competitive protein binding. Sephadex LH-20 column chromatographic separation of extracts from these tissues showed that, in placental and molar tissue, 85 to 95% of the extracts were progesterone and very small amounts of 20 alpha-dihydroprogesterone and 17 alpha-hydroxyprogesterone. The concentration of progesterone in the placenta were 368.8 and 317.2 ng/g tissue, respectively, while in molar tissue the concentration were 2474.5, 1974.6, and 4146.0 ng/g tissue, respectively. Progesterone concentration in ovarian tissue was between 1121;2 and 1440.9 ng/g tissue. It is suggested that the high concentration of progesterone in molar tissue reflects functional capacity of the abnormal trophoblast in progesterone synthesis and accumulation of progesterone due to absence of a fetus. The lower concentration of progesterone in the ovary in molar pregnancy would appear to suggest that the ovary is a secondary source of progesterone in molar pregnancy.

Chorionic Gonadotropin↗

PubMed1974