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Biomedical subjects

E S Thomson

Publications and source records attributed to E S Thomson.

11 recordsLinked to original sources
PubMed1996

Radiation properties of a miniature X-ray device for radiosurgery.

An alternative technology for performing interstitial intracranial radiosurgery is presented. Treatments are performed intraoperatively using a stereotactically mounted, miniature X-ray device. A concentrated, spherical pattern of X-rays is generated about the tip of a needle-like probe, which is inserted into the site of the lesion allowing the absorbed dose to healthy tissue to be minimized. A description of the device is given and results of investigations into the operating characteristics discussed.

Equipment Design↗
PubMed1995

No evidence for a chronic effect of smoking on energy expenditure.

OBJECTIVE: To investigate whether effects of smoking on energy expenditure (EE) extend chronically beyond smoking the last cigarette. DESIGN: Eight subjects (5M,3F) were studied over three consecutive months, after smoking as normal (S) on 1-3 occasions, and after not smoking for 4-8 weeks (NS) on 1-2 occasions. On each occasion subjects underwent one 32-h measurement of EE in a respiration chamber (8-h overnight plus a 24-h day, with no smoking in the chamber) and one measure of basal metabolic rate (BMR) on exit from the chamber. Statistical differences were determined using paired t-tests. RESULTS: There were no differences between S and NS for any of the EE measures, either including (n = 8) or excluding (n = 5) three subjects whose urinary cotinine excretions suggested failure to stop smoking during NS. For S and NS (N = 5) respectively, overnight EEs during the first night in the respiration chamber were 2.08 +/- 0.38 and 2.10 +/- 0.42 MJ/8-h; 24-h EEs during 12-36 hours after the last cigarette were 8.38 +/- 1.6 and 8.24 +/- 1.34 MJ/day, and BMRs were 6.51 +/- 1.21 and 6.50 +/- 1.07 MJ/day. CONCLUSION: We found no evidence for a chronic effect of smoking on EE.

Adult↗
PubMed1992

Cranial stereotactic multiple arc radiotherapy; treatment planning using angiographic images.

Stereotactic multiple arc radiotherapy (SMART) is an irradiation technique developed to treat small intracranial lesions. Calculation of absorbed-dose patterns for this treatment has traditionally involved complex computer programs incorporating algorithms designed to reconstruct the shape of the patient's head from computerized tomography (CT) images. A large proportion of the patients treated with SMART, however, have arteriovenous malformations for which angiography provides a better idea of lesion size and position than CT. This paper describes a computer program developed at St Bartholomew's Hospital which enables calculation of absorbed dose for a SMART treatment directly from angiographic radiographs, avoiding the need for CT. The program is compared with the existing CT-based treatment planning program.

Angiography↗
PubMed1990

Stereotactic multiple arc radiotherapy.

A radiotherapy technique is presented for delivering a concentrated pattern of absorbed dose to intracranial lesions. Treatment takes place on a conventional, isocentrically mounted linear accelerator, rotated in several planes around a single target site. A new, relocatable stereotactic frame is used which enables fractionated radiotherapy to be administered if required. Calculations of the absorbed dose distribution in three orthogonal planes are performed using specially prepared software on a computer used for standard treatment planning. In this way, the need for excessive computing power is avoided.

Brain Diseases↗
PubMed1989

Paediatric brachytherapy. II. Brain implantation.

The case histories of four children with brain tumours, for whom stereotactic brachytherapy was indicated, are presented from the St Bartholomew's Hospital intracranial brachytherapy programme. The recent evolution of the computed-tomography-directed stereotactic technique is described and the uses of different radionuclides (198Au, 192Ir) are discussed. The future of brachytherapy for paediatric brain tumours is debated.

Adolescent↗
PubMed1988

Prediction of energy expenditure: simplified FAO/WHO/UNU factorial method vs continuous respirometry and habitual energy intake.

This study assessed a simple factorial method to predict energy expenditure (EE) in confined and free-living subjects. Thirteen subjects (seven male, 6 female) were studied on four occasions each. Measurements included BMR, 24-h EE by continuous respirometry, 4-d records of intake and activities, body weight, and urine collections. Agreement between measured and predicted 24-h EE was within +/- 2% for group results and +/- 10% for most individuals. Individual agreement was improved to within +/- 5% by using measured rather than predicted BMR. Habitual energy intake was 7.3% greater (p less than 0.05) than predicted EE in males and 5.1% less (NS) in females. Validatory data suggested overrecording of intake in males and underrecording in females. Large individual differences between habitual intake and predicted EE were observed but were significantly (p less than 0.01) correlated with both weight change and protein balance. Our simple factorial method provided acceptable estimates of EE in the subjects studied.

Adult↗
PubMed1988

An iodine-125 plaque for radiotherapy of the eye: manufacture and dosimetric considerations.

A comparison of computer dose calculations and thermoluminescent dosemeter measurements in a phantom is given for an iodine-125 plaque for radiotherapy of the eye. The off-central-axis measurements and their relationship to the central-axis depth doses are documented. It was found that the gold backing of the applicator did not influence dosimetry in the phantom and thus the eye.

Brachytherapy↗
PubMed1987

The effect of smoking two cigarettes on resting metabolic rate with and without food.

Resting metabolic rate (RMR) was measured using a ventilated hood apparatus in 15 subjects before (BMR) and for 5 h after (5HEE) four treatments. In 10 smokers (five occasional and five habitual) the treatments were: food (600 kcal (2.51 MJ) breakfast) with and without smoking two cigarettes (F +/- S) and no food with and without smoking (NF +/- S). In five non-smokers duplicate measurements of food (F-S) and no food (NF-S) were made. In non-smokers the thermic effect of food (TEF) averaged 9.35 per cent of the ingested energy. Duplicate measures of 5HEE showed good reproducibility both with and without food (c.v. 2.5 and 1.3 per cent respectively). In smokers, RMR did not increase after smoking even during the first 15-30 min. There were no apparent differences in response between occasional and habitual smokers. 5HEE and delta 5HEE (5HEE minus BMR) were significantly lower after food with smoking than without smoking (-16 kcal (67 kJ)/5 h, P less than 0.001 and -14 kcal (59 kJ)/5 h, P less than 0.02 respectively) but not significantly lower after smoking without food. TEF was lower with smoking (8.6 per cent of ingested energy) than without smoking (10.0 per cent of ingested energy) but the difference was not significant (P = 0.23). TEF in smokers regardless of treatment averaged 9.3 per cent of the ingested energy. We conclude that any effects of smoking two cigarettes in isolation after overnight deprivation are too small or too variable to consistently influence RMR or the thermic effect of food.

Adult↗